Emerging viruses in the felidae: Shifting paradigms

Viruses

Volumn 4, Issue 2, 2012, Pages 236-257

  O'Brien, Stephen J ^a,e   Troyer, Jennifer L ^b   Brown, Meredith A ^c   Johnson, Warren E ^a   Antunes, Agostinho ^d   Roelke, Melody E ^b   Pecon Slattery, Jill ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c Banfield Pet Hospital   (United States)

^d UNIVERSITY OF PORTO   (Portugal)

^e ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

Author keywords

FCoV; Felidae; FeLV; FIV

Indexed keywords

CORONAVIRUS; DOMESTIC ANIMAL; FELIDAE; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; FELINE IMMUNODEFICIENCY VIRUS; FELINE INFECTIOUS PERITONITIS; FELINE LEUKEMIA; FELINE LEUKEMIA VIRUS; HUMAN; NONHUMAN; PHYLOGENETIC TREE; REVIEW; SEQUENCE ANALYSIS; VIRUS IDENTIFICATION; VIRUS MUTATION; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; CAT DISEASES; CATS; COMMUNICABLE DISEASES, EMERGING; CORONAVIRUS, FELINE; IMMUNODEFICIENCY VIRUS, FELINE; LEUKEMIA VIRUS, FELINE;

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; FELINE LEUKEMIA VIRUS; FELIS CATUS;

EID: 84863403134     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v4020236     Document Type: Review

References (121)

1. Driscoll, C.A.; Macdonald, D.W.; O'Brien, S.J. From wild animals to domestic pets, an evolutionary view of domestication. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 9971-9978.
2. WHO. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. Available online: http://www.who.int/csr/sars/country/table2004_2004_2021/en/index.html (accessed on 16 January 2012).
3. Hardy, W.D., Jr.; McClelland, A.J.; Zuckerman, E.E.; Snyder, H.W., Jr.; MacEwen, E.G.; Francis, D.; Essex, M. Development of virus non-producer lymphosarcomas in pet cats exposed to FeLv. Nature 1980, 288, 90-92.
4. Pedersen, N.C.; Ho, E.W.; Brown, M.L.; Yamamoto, J.K. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science 1987, 235, 790-793.
5. Mullins, J.I.; Hoover, E.A. Molecular aspects of feline leukemia virus pathogenesis. In Retrovirus Biology and Human Disease; Gallo, R.C., Wong-Staal, F., Eds.; Dekker: New York, NY, USA, 1990; pp. 87-116.
6. Slattery, J.P.; Franchini, G.; Gessain, A. Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res. 1999, 9, 525-540.
7. Troyer, J.L.; Pecon-Slattery, J.; Roelke, M.E.; Johnson, W.; VandeWoude, S.; Vazquez-Salat, N.; Brown, M.; Frank, L.; Woodroffe, R.; Winterbach, C.; et al. Seroprevalence and genomic divergence of circulating strains of feline immunodeficiency virus among Felidae and Hyaenidae species. J. Virol. 2005, 79, 8282-8294.
8. O'Brien, S.J.; Nelson, G.W. Human genes that limit AIDS. Nat. Genet. 2004, 36, 565-574.
9. Pedersen, N.C. A review of feline infectious peritonitis virus infection: 1963-2008. J. Feline Med. Surg. 2009, 11, 225-258.
10. Eickmann, M.; Becker, S.; Klenk, H.D.; Doerr, H.W.; Stadler, K.; Censini, S.; Guidotti, S.; Masignani, V.; Scarselli, M.; Mora, M.; et al. Phylogeny of the SARS coronavirus. Science 2003, 302, 1504-1505.
11. Ruscetti, S.K.; Turek, L.P.; Sherr, C.J. Three independent isolates of feline sarcoma virus code for three distinct gag-x polyproteins. J. Virol. 1980, 35, 259-264.
12. Maeda, N.; Fan, H.; Yoshikai, Y. Oncogenesis by retroviruses: Old and new paradigms. Rev. Med. Virol. 2008, 18, 387-405.
13. Harder, T.C.; Vahlenkamp, T.W. Influenza virus infections in dogs and cats. Vet. Immunol. Immunopathol. 2009, 134, 54-60.
14. Van Kerkhove, M.D.; Mumford, E.; Mounts, A.W.; Bresee, J.; Ly, S.; Bridges, C.B.; Otte, J. Highly pathogenic avian influenza (H5N1): Pathways of exposure at the animal-human interface, a systematic review. PLoS One 2011, 6, e14582.
15. Thiry, E.; Addie, D.; Belak, S.; Boucraut-Baralon, C.; Egberink, H.; Frymus, T.; Gruffydd-Jones, T.; Hartmann, K.; Hosie, M.J.; Lloret, A.; et al. Feline herpesvirus infection. ABCD guidelines on prevention and management. J. Feline Med. Surg. 2009, 11, 547-555.
16. Winkler, I.G.; Flugel, R.M.; Lochelt, M.; Flower, R.L. Detection and molecular characterisation of feline foamy virus serotypes in naturally infected cats. Virology 1998, 247, 144-151.
17. Meiering, C.D.; Linial, M.L. Historical perspective of foamy virus epidemiology and infection. Clin. Microbiol. Rev. 2001, 14, 165-176.
18. Radford, A.D.; Coyne, K.P.; Dawson, S.; Porter, C.J.; Gaskell, R.M. Feline calicivirus. Vet. Res. 2007, 38, 319-335.
19. Blanton, L.H.; Adams, S.M.; Beard, R.S.; Wei, G.; Bulens, S.N.; Widdowson, M.A.; Glass, R.I.; Monroe, S.S. Molecular and epidemiologic trends of caliciviruses associated with outbreaks of acute gastroenteritis in the United States, 2000-2004. J. Infect. Dis. 2006, 193, 413-421.
20. Ikeda, Y.; Nakamura, K.; Miyazawa, T.; Takahashi, E.; Mochizuki, M. Feline host range of canine parvovirus: Recent emergence of new antigenic types in cats. Emerg. Infect. Dis. 2002, 8, 341-346.
21. Brown, K.E. The expanding range of parvoviruses which infect humans. Rev. Med. Virol. 2010, 20, 231-244.
22. Munson, L. Feline morbillivirus infection. In Infectious Diseases of Wild Animals; Williams, E.S., Barker, I.K., Eds.; Iowa State University Press: Ames, IA, USA, 2001; pp. 59-62.
23. Rota, P.A.; Brown, K.; Mankertz, A.; Santibanez, S.; Shulga, S.; Muller, C.P.; Hubschen, J.M.; Siqueira, M.; Beirnes, J.; Ahmed, H.; et al. Global distribution of measles genotypes and measles molecular epidemiology. J. Infect. Dis. 2011, 204, S514-S523.
24. Masters, P.S. The molecular biology of coronaviruses. Adv. Virus Res. 2006, 66, 193-292.
25. Pedersen, N.C.; Evermann, J.F.; McKeirnan, A.J.; Ott, R.L. Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683. Am. J. Vet. Res. 1984, 45, 2580-2585.
26. de Groot, R.J. Feline infectous peritonitis. In The Coronoviridae; Siddell, S.G., Ed.; Plenum Press: New York, NY, USA, 1995; pp. 293-309.
27. Addie, D.D. Clustering of feline coronaviruses in multicat households. Vet. J. 2000, 159, 8-9.
28. Addie, D.D.; Jarrett, O. A study of naturally occurring feline coronavirus infections in kittens. Vet. Rec. 1992, 130, 133-137.
29. Kennedy, M.; Citino, S.; McNabb, A.H.; Moffatt, A.S.; Gertz, K.; Kania, S. Detection of feline coronavirus in captive Felidae in the USA. J. Vet. Diagn. Invest. 2002, 14, 520-522.
30. Foley, J.E.; Poland, A.; Carlson, J.; Pedersen, N.C. Patterns of feline coronavirus infection and fecal shedding from cats in multiple-cat environments. J. Am. Vet. Med. Assoc. 1997, 210, 1307-1312.
31. Foley, J.E.; Poland, A.; Carlson, J.; Pedersen, N.C. Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus. J. Am. Vet. Med. Assoc. 1997, 210, 1313-1318.
32. Weiss, R.C.; Scott, F.W. Pathogenesis of feline infectious peritonitis: Nature and development of viremia. Am. J. Vet. Res. 1981, 42, 382-390.
33. Kipar, A.; Kohler, K.; Leukert, W.; Reinacher, M. A comparison of lymphatic tissues from cats with spontaneous feline infectious peritonitis (FIP), cats with FIP virus infection but no FIP, and cats with no infection. J. Comp. Pathol. 2001, 125, 182-191.
34. Kipar, A.; Meli, M.L.; Failing, K.; Euler, T.; Gomes-Keller, M.A.; Schwartz, D.; Lutz, H.; Reinacher, M. Natural feline coronavirus infection: Differences in cytokine patterns in association with the outcome of infection. Vet. Immunol. Immunopathol. 2006, 112, 141-155.
35. Rottier, P.J. The Coronavirus Membrane Glycoprotein. In The Coronaviridae; Siddell, S.G., Ed.; Plenum Press: New York, NY, USA, 1995; pp. 115-140.
36. Poland, A.M.; Vennema, H.; Foley, J.E.; Pedersen, N.C. Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus. J. Clin. Microbiol. 1996, 34, 3180-3184.
37. Vennema, H.; Poland, A.; Foley, J.; Pedersen, N.C. Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. Virology 1998, 243, 150-157.
38. Addie, D.D.; Jarrett, J.O. Feline coronavirus antibodies in cats. Vet. Rec. 1992, 131, 202-203.
39. Pedersen, N.C.; Black, J.W.; Boyle, J.F.; Evermann, J.F.; McKeirnan, A.J.; Ott, R.L. Pathogenic differences between various feline coronavirus isolates. Adv. Exp. Med. Biol. 1984, 173, 365-380.
40. Pedersen, N., Liu, H, Dodd, KA, Pesavento, PA. Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis. Viruses 2009, 1, 166-184.
41. Anishchenko, M.; Bowen, R.A.; Paessler, S.; Austgen, L.; Greene, I.P.; Weaver, S.C. Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4994-4999.
42. Mongkolsapaya, J.; Dejnirattisai, W.; Xu, X.N.; Vasanawathana, S.; Tangthawornchaikul, N.; Chairunsri, A.; Sawasdivorn, S.; Duangchinda, T.; Dong, T.; Rowland-Jones, S.; et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat. Med. 2003, 9, 921-927.
43. Brown, M.A.; Troyer, J.L.; Pecon-Slattery, J.; Roelke, M.E.; O'Brien, S.J. Genetics and pathogenesis of feline infectious peritonitis virus. Emerg. Infect. Dis. 2009, 15, 1445-1452.
44. Chang, H.W.; Egberink, H.F.; Rottier, P.J. Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory. Emerg. Infect. Dis. 2011, 17, 744-746.
45. Norris JM, B.K., White JD, Baral RM, Catt MJ, Malik R. Clinicopathological findings associated with feline infectious peritonitis in Sydney, Australia: 42 cases (1990-2002). Aust. Vet. 2005, 83, 666-673.
46. Pesteanu-Somogyi LD, R.C., Pressler BM. Prevalence of feline infectious peritonitis in specific cat breeds. J. Feline Med. Surg. 2006, 8, 1-5.
47. Olmsted, R.A.; Barnes, A.K.; Yamamoto, J.K.; Hirsch, V.M.; Purcell, R.H.; Johnson, P.R. Molecular cloning of feline immunodeficiency virus. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 2448-2452.
48. Bendinelli, M.; Pistello, M.; Lombardi, S.; Poli, A.; Garzelli, C.; Matteucci, D.; Ceccherini-Nelli, L.; Malvaldi, G.; Tozzini, F. Feline immunodeficiency virus: An interesting model for AIDS studies and an important cat pathogen. Clin. Microbiol. Rev. 1995, 8, 87-112.
49. Willett, B.J.; Flynn, J.N.; Hosie, M.J. FIV infection of the domestic cat: An animal model for AIDS. Immunol. Today 1997, 18, 182-189.
50. Burkhard, M.J.; Dean, G.A. Transmission and immunopathogenesis of FIV in cats as a model for HIV. Curr. HIV Res. 2003, 1, 15-29.
51. Sodora, D.L.; Shpaer, E.G.; Kitchell, B.E.; Dow, S.W.; Hoover, E.A.; Mullins, J.I. Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns. J. Virol. 1994, 68, 2230-2238.
52. Kakinuma, S.; Motokawa, K.; Hohdatsu, T.; Yamamoto, J.K.; Koyama, H.; Hashimoto, H. Nucleotide sequence of feline immunodeficiency virus: Classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes. J. Virol. 1995, 69, 3639-3646.
53. Carpenter, M.A.; Brown, E.W.; MacDonald, D.W.; O'Brien S. J. Phylogeographic patterns of feline immunodeficiency virus genetic diversity in the domestic cat. Virology 1998, 251, 234-243.
54. Hayward, J.J.; Rodrigo, A.G. Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus). Vet. Immunol. Immunopathol. 2009, 134, 68-74.
55. Pecoraro, M.R.; Tomonaga, K.; Miyazawa, T.; Kawaguchi, Y.; Sugita, S.; Tohya, Y.; Kai, C.; Etcheverrigaray, M.E.; Mikami, T. Genetic diversity of Argentine isolates of feline immunodeficiency virus. J. Gen. Virol. 1996, 77, 2031-2035.
56. Johnson, W.E.; Eizirik, E.; Pecon-Slattery, J.; Murphy, W.J.; Antunes, A.; Teeling, E.; O'Brien, S.J. The late Miocene radiation of modern Felidae: A genetic assessment. Science 2006, 311, 73-77.
57. Antunes, A.; Troyer, J.L.; Roelke, M.E.; Pecon-Slattery, J.; Packer, C.; Winterbach, C.; Winterbach, H.; Hemson, G.; Frank, L.; Stander, P.; et al. The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. PLoS Genet. 2008, 4, e1000251.
58. Pecon-Slattery, J.; Troyer, J.L.; Johnson, W.E.; O'Brien, S.J. Evolution of feline immunodeficiency virus in Felidae: Implications for human health and wildlife ecology. Vet. Immunol. Immunopathol. 2008, 123, 32-44.
59. Olmsted, R.A.; Langley, R.; Roelke, M.E.; Goeken, R.M.; Adger-Johnson, D.; Goff, J.P.; Albert, J.P.; Packer, C.; Laurenson, M.K.; Caro, T.M.; et al. Worldwide prevalence of lentivirus infection in wild feline species: Epidemiologic and phylogenetic aspects. J. Virol. 1992, 66, 6008-6018.
60. Carpenter, M.A.; O'Brien, S.J. Coadaptation and immunodeficiency virus: Lessons from the Felidae. Curr. Opin. Genet. Dev. 1995, 5, 739-745.
61. Carpenter, M.A.; Brown, E.W.; Culver, M.; Johnson, W.E.; Pecon-Slattery, J.; Brousset, D.; O'Brien, S.J. Genetic and phylogenetic divergence of feline immunodeficiency virus in the puma (Puma concolor). J. Virol. 1996, 70, 6682-6693.
62. Franklin, S.P.; Troyer, J.L.; Terwee, J.A.; Lyren, L.M.; Boyce, W.M.; Riley, S.P.; Roelke, M.E.; Crooks, K.R.; Vandewoude, S. Frequent transmission of immunodeficiency viruses among bobcats and pumas. J. Virol. 2007, 81, 10961-10969.
63. VandeWoude, S.; Apetrei, C. Going wild: Lessons from naturally occurring T-lymphotropic lentiviruses. Clin. Microbiol. Rev. 2006, 19, 728-762.
64. Troyer, J.L.; Vandewoude, S.; Pecon-Slattery, J.; McIntosh, C.; Franklin, S.; Antunes, A.; Johnson, W.; O'Brien, S.J. FIV cross-species transmission: An evolutionary prospective. Vet. Immunol. Immunopathol. 2008, 123, 159-166.
65. Pecon-Slattery, J.; McCracken, C.L.; Troyer, J.L.; VandeWoude, S.; Roelke, M.; Sondgeroth, K.; Winterbach, C.; Winterbach, H.; O'Brien, S.J. Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild. BMC Genom. 2008, 9, 66.
66. Olmsted, R.A.; Hirsch, V.M.; Purcell, R.H.; Johnson, P.R. Nucleotide sequence analysis of feline immunodeficiency virus: Genome organization and relationship to other lentiviruses. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 8088-8092.
67. Langley, R.J.; Hirsch, V.M.; O'Brien, S.J.; Adger-Johnson, D.; Goeken, R.M.; Olmsted, R.A. Nucleotide sequence analysis of puma lentivirus (PLV-14): Genomic organization and relationship to other lentiviruses. Virology 1994, 202, 853-864.
68. Barr, M.C.; Zou, L.; Long, F.; Hoose, W.A.; Avery, R.J. Proviral organization and sequence analysis of feline immunodeficiency virus isolated from a Pallas' cat. Virology 1997, 228, 84-91.
69. Ostrowski, S.; Van Vuuren, M.; Lenain, D.M.; Durand, A. A serologic survey of wild felids from central west Saudi Arabia. J. Wildl. Dis. 2003, 39, 696-701.
70. Leutenegger, C.M.; Hofmann-Lehmann, R.; Riols, C.; Liberek, M.; Worel, G.; Lups, P.; Fehr, D.; Hartmann, M.; Weilenmann, P.; Lutz, H. Viral infections in free-living populations of the European wildcat. J. Wildl. Dis. 1999, 35, 678-686.
71. Daniels, M.J.; Golder, M.C.; Jarrett, O.; MacDonald, D.W. Feline viruses in wildcats from Scotland. J. Wildl. Dis. 1999, 35, 121-124.
72. Fromont, E.; Sager, A.; Leger, F.; Bourguemestre, F.; Jouquelet, E.; Stahl, P.; Pontier, D.; Artois, M. Prevalence and pathogenicity of retroviruses in wildcats in France. Vet. Rec. 2000, 146, 317-319.
73. Nishimura, Y.; Goto, Y.; Yoneda, K.; Endo, Y.; Mizuno, T.; Hamachi, M.; Maruyama, H.; Kinoshita, H.; Koga, S.; Komori, M.; et al. Interspecies transmission of feline immunodeficiency virus from the domestic cat to the Tsushima cat (Felis bengalensis euptilura) in the wild. J. Virol. 1999, 73, 7916-7921.
74. Nakamura, K.; Miyazawa, T.; Ikeda, Y.; Sato, E.; Nishimura, Y.; Nguyen, N.T.; Takahashi, E.; Mochizuki, M.; Mikami, T. Contrastive prevalence of feline retrovirus infections between northern and southern Vietnam. J. Vet. Med. Sci. 2000, 62, 921-923.
75. Lutz, H.; Isenbugel, E.; Lehmann, R.; Sabapara, R.H.; Wolfensberger, C. Retrovirus infections in non-domestic felids: Serological studies and attempts to isolate a lentivirus. Vet. Immunol. Immunopathol. 1992, 35, 215-224.
76. Franklin, S.P.; Troyer, J.L.; Terwee, J.A.; Lyren, L.M.; Kays, R.W.; Riley, S.P.; Boyce, W.M.; Crooks, K.R.; Vandewoude, S. Variability in assays used for detection of lentiviral infection in bobcats (Lynx rufus), pumas (Puma concolor), and ocelots (Leopardus pardalis). J. Wildl. Dis. 2007, 43, 700-710.
77. Biek, R.; Rodrigo, A.G.; Holley, D.; Drummond, A.; Anderson, C.R., Jr.; Ross, H.A.; Poss, M. Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars. J. Virol. 2003, 77, 9578-9589.
78. Blanco, K.; Peña, R.; Hernández, C.; Jiménez, M.; Araya, L.N.; Romero, J.J.; Dolz, G. Serological detection of viral infections in captive wild cats from Costa Rica. Vet. Med. Int. 2011, 2011, 879029.
79. Thalwitzer, S.; Wachter, B.; Robert, N.; Wibbelt, G.; Muller, T.; Lonzer, J.; Meli, M.L.; Bay, G.; Hofer, H.; Lutz, H. Seroprevalences to viral pathogens in free-ranging and captive cheetahs (Acinonyx jubatus) on Namibian Farmland. Clin. Vaccine Immunol. 2009, 17, 232-238.
80. Osofsky, S.A.; Hirsch, K.J.; Zuckerman, E.E.; et al. Feline lentivirus and feline oncovirus status of free-ranging lions (Panthera leo), leopards (Panthera pardus), and cheetahs (Acinonyx jubatus) in Botswana: A regional perspective. J. Zoo wildl. Med. 1996, 27, 453-467.
81. Meli, M.L.; Cattori, V.; Martinez, F.; Lopez, G.; Vargas, A.; Simon, M.A.; Zorrilla, I.; Munoz, A.; Palomares, F.; Lopez-Bao, J.V.; et al. Feline leukemia virus and other pathogens as important threats to the survival of the critically endangered Iberian lynx (Lynx pardinus). PLoS One 2009, 4, e4744.
82. Biek, R.; Zarnke, R.L.; Gillin, C.; Wild, M.; Squires, J.R.; Poss, M. Serologic survey for viral and bacterial infections in western populations of Canada lynx (Lynx canadensis). J. Wildl. Dis. 2002, 38, 840-845.
83. Franklin, S.P.; Kays, R.W.; Moreno, R.; TerWee, J.A.; Troyer, J.L.; Vande Woude, S. Ocelots on Barro Colorado Island are infected with feline immunodeficiency virus but not other common feline and canine viruses. J. Wildl. Dis. 2008, 44, 760-765.
84. Brennan, G.; Podell, M.D.; Wack, R.; Kraft, S.; Troyer, J.L.; Bielefeldt-Ohmann, H.; VandeWoude, S. Neurologic disease in captive lions (Panthera leo) with low-titer lion lentivirus infection. J. Clin. Microbiol. 2006, 44, 4345-4352.
85. Driciru, M.; Siefert, L.; Prager, K.C.; Dubovi, E.; Sande, R.; Princee, F.; Friday, T.; Munson, L. A serosurvey of viral infections in lions (Panthera leo), from Queen Elizabeth National Park, Uganda. J. Wildl. Dis. 2006, 42, 667-671.
86. Adams, H.; van Vuuren, M.; Kania, S.; Bosman, A.M.; Keet, D.; New, J.; Kennedy, M. Sensitivity and specificity of a nested polymerase chain reaction for detection of lentivirus infection in lions (Panthera leo). J. Zoo Wildl. Med. 2011, 41, 608-615.
87. Packer, C.; Altizer, S.; Appel, M.; Brown, E.; Martenson, J.; O'Brien, S.J.; Roelke-Parker, M.; Hofmann-Lehmann, R.; Lutz, H. Viruses of the Serengeti: Patterns of infection and mortality in African lions. J. Anim. Ecol. 1999, 68, 1161-1178.
88. Roelke, M.E.; Brown, M.A.; Troyer, J.L.; Winterbach, H.; Winterbach, C.; Hemson, G.; Smith, D.; Johnson, R.C.; Pecon-Slattery, J.; Roca, A.L.; et al. Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions. Virology 2009, 390, 1-12.
89. Roelke, M.E.; Pecon-Slattery, J.; Taylor, S.; Citino, S.; Brown, E.; Packer, C.; Vandewoude, S.; O'Brien, S.J. T-lymphocyte profiles in FIV-infected wild lions and pumas reveal CD4 depletion. J. Wildl. Dis. 2006, 42, 234-248.
90. Keele, B.F.; Jones, J.H.; Terio, K.A.; Estes, J.D.; Rudicell, R.S.; Wilson, M.L.; Li, Y.; Learn, G.H.; Beasley, T.M.; Schumacher-Stankey, J.; et al. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature 2009, 460, 515-519.
91. Roelke-Parker, M.E.; Munson, L.; Packer, C.; Kock, R.; Cleaveland, S.; Carpenter, M.; O'Brien, S.J.; Pospischil, A.; Hofmann-Lehmann, R.; Lutz, H.; et al. A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature 1996, 379, 441-445.
92. Brown, E.W.; Yuhki, N.; Packer, C.; O'Brien, S.J. A lion lentivirus related to feline immunodeficiency virus: Epidemiologic and phylogenetic aspects. J. Virol. 1994, 68, 5953-5968.
93. Troyer, J.L.; Pecon-Slattery, J.; Roelke, M.E.; Black, L.; Packer, C.; O'Brien, S.J. Patterns of feline immunodeficiency virus multiple infection and genome divergence in a free-ranging population of African lions. J. Virol. 2004, 78, 3777-3791.
94. Troyer, J.L.; Roelke, M.E.; Jespersen, J.M.; Baggett, N.; Buckley-Beason, V.; Macnulty, D.; Craft, M.; Packer, C.; Pecon-Slattery, J.; O'Brien, S.J. FIV diversity: FIV(Ple) subtype composition may influence disease outcome in African lions. Vet. Immunol. Immunopathol. 2011, 143, 338-346.
95. VandeWoude, S.; Hageman, C.A.; O'Brien, S.J.; Hoover, E.A. Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus. J. Acquir. Immune Defic. Syndr. 2002, 29, 1-10.
96. VandeWoude, S.; Hageman, C.L.; Hoover, E.A. Domestic cats infected with lion or puma lentivirus develop anti-feline immunodeficiency virus immune responses. J. Acquir. Immune Defic. Syndr. 2003, 34, 20-31.
97. Terwee, J.A.; Carlson, J.K.; Sprague, W.S.; Sondgeroth, K.S.; Shropshire, S.B.; Troyer, J.L.; VandeWoude, S. Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus. Virology 2008, 377, 63-70.
98. Jarrett, W.F.; Crawford, E.M.; Martin, W.B.; Davie, F. A Virus-Like Particle Associated with Leukemia (Lymphosarcoma). Nature 1964, 202, 567-569.
99. Hardy, W.D. The virology, immunology and epidemiology of the feline leukemia virus. In Feline Leukemia Virus; Hardy, W.D., Essex, M., McClelland, A.J., Eds.; Elsevier/North-Holland: New York, NY, USA, 1980; pp. 33-78.
100. Overbaugh, J.; Bangham, C.R. Selection forces and constraints on retroviral sequence variation. Science 2001, 292, 1106-1109.
101. Phipps, A.J.; Chen, H.; Hayes, K.A.; Roy-Burman, P.; Mathes, L.E. Differential pathogenicity of two feline leukemia virus subgroup A molecular clones, pFRA and pF6A. J. Virol. 2000, 74, 5796-5801.
102. Neil, J.C.; Fulton, R.; Rigby, M.; Stewart, M. Feline leukaemia virus: Generation of pathogenic and oncogenic variants. Curr. Top. Microbiol. Immunol. 1991, 171, 67-93.
103. Stewart, M.A.; Warnock, M.; Wheeler, A.; Wilkie, N.; Mullins, J.I.; Onions, D.E.; Neil, J.C. Nucleotide sequences of a feline leukemia virus subgroup A envelope gene and long terminal repeat and evidence for the recombinational origin of subgroup B viruses. J. Virol. 1986, 58, 825-834.
104. Benveniste, R.E.; Sherr, C.J.; Todaro, G.J. Evolution of type C viral genes: Origin of feline leukemia virus. Science 1975, 190, 886-888.
105. Cunningham, M.W.; Brown, M.A.; Shindle, D.B.; Terrell, S.P.; Hayes, K.A.; Ferree, B.C.; McBride, R.T.; Blankenship, E.L.; Jansen, D.; Citino, S.B.; et al. Epizootiology and management of feline leukemia virus in the Florida puma. J. Wildl. Dis. 2008, 44, 537-552.
106. Kennedy-Stoskopf, S. Emerging viral infections in large cats. In Zoo and Wild Animal Medicine; Fowler, M.E., Miller, R.E., Eds.; W.B. Saunders: Philadelphia, PA, USA, 1999; pp. 401-410.
107. Brown, M.A.; Cunningham, M.W.; Roca, A.L.; Troyer, J.L.; Johnson, W.E.; O'Brien, S.J. Genetic characterization of feline leukemia virus from Florida panthers. Emerg. Infect. Dis. 2008, 14, 252-259.
108. Young, S.P.; Goldman, A. The Puma, Mysterious American Cat; Dover Publications: New York, NY, USA, 1946; p. 358.
109. Nowak, R.M.; McBride, R. Status survey of the Florida panther. In World Wildlife Fund Yearbook 1973-1974; Danbury Press: Danbury, CT, USA, 1974; pp. 112-113.
110. Johnson, W.E.; Onorato, D.P.; Roelke, M.E.; Land, E.D.; Cunningham, M.; Belden, R.C.; McBride, R.; Jansen, D.; Lotz, M.; Shindle, D.; et al. Genetic restoration of the Florida panther. Science 2010, 329, 1641-1645.
111. Seal, U.S. A Plan for Genetic Restoration and Management of the Florida Panther (Felis concolor coryi); White Oak Conservation Center: Yulee, FL, USA, 1994; p. 23.
112. McBride, R. The Documented Panther Population (DPP) and Its Current Distribution from July 1, 2002 to June 30, 2003; Livestock Protection Company: Alpine, TA, USA, 2003; p. 11.
113. Benveniste, R.E.; Todaro, G.J. Segregation of RD-114 AND FeL-V-related sequences in crosses between domestic cat and leopard cat. Nature 1975, 257, 506-508.
114. Chandhasin, C.; Coan, P.N.; Pandrea, I.; Grant, C.K.; Lobelle-Rich, P.A.; Puetter, A.; Levy, L.S. Unique long terminal repeat and surface glycoprotein gene sequences of feline leukemia virus as determinants of disease outcome. J. Virol. 2005, 79, 5278-5287.
115. Chandhasin, C.; Coan, P.N.; Levy, L.S. Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum. J. Virol. 2005, 79, 1351-1360.
116. Lee, I.T.; Levy, J.K.; Gorman, S.P.; Crawford, P.C.; Slater, M.R. Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned freeroaming cats. J. Am. Vet. Med. Assoc. 2002, 220, 620-622.
117. O'Connor, T.P., Jr.; Tonelli, Q.J.; Scarlett, J.M. Report of the National FeLV/FIV Awareness Project. J. Am. Vet. Med. Assoc. 1991, 199, 1348-1353.
118. Ishida, T.; Washizu, T.; Toriyabe, K.; Motoyoshi, S.; Tomoda, I.; Pedersen, N.C. Feline immunodeficiency virus infection in cats of Japan. J. Am. Vet. Med. Assoc. 1989, 194, 221-225.
119. O'Connor, T.P., Jr.; Tanguay, S.; Steinman, R.; Smith, R.; Barr, M.C.; Yamamoto, J.K.; Pedersen, N.C.; Andersen, P.R.; Tonelli, Q.J. Development and evaluation of immunoassay for detection of antibodies to the feline T-lymphotropic lentivirus (feline immunodeficiency virus). J. Clin. Microbiol. 1989, 27, 474-479.
120. Yamamoto, J.K.; Hansen, H.; Ho, E.W.; Morishita, T.Y.; Okuda, T.; Sawa, T.R.; Nakamura, R.M.; Pedersen, N.C. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. J. Am. Vet. Med. Assoc. 1989, 194, 213-220.
121. Cohen, N.D.; Carter, C.N.; Thomas, M.A.; Lester, T.L.; Eugster, A.K. Epizootiologic association between feline immunodeficiency virus infection and feline leukemia virus seropositivity. J. Am. Vet. Med. Assoc. 1990, 197, 220-225.