Sources of and technical approaches for the abatement of tobacco specific nitrosamine formation in moist smokeless tobacco products

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 942-948

  Fisher, Michael T ^a   Bennett, Cliff B ^b   Hayes, Alec ^a   Kargalioglu, Yahya ^a   Knox, Brandy L ^a   Xu, Dongmei ^a   Muhammad Kah, Raheema ^a   Gaworski, Charles L ^a  

^a Altria Client Services Inc   (United States)

^b NONE   (United States)

Author keywords

Fermentation; MST; Smokeless tobacco; Tobacco

Indexed keywords

NITRITE; NITROSAMINE; TOBACCO SPECIFIC NITROSAMINE; UNCLASSIFIED DRUG;

AGRICULTURAL PARAMETERS; AGRONOMY; ARTICLE; BACTERIAL GROWTH; BARN SIZE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CURING PRACTICE; DARK FIRE CURED TOBACCO; ENVIRONMENTAL SANITATION; FERMENTATION; GROWTH INHIBITION; MOIST SMOKELESS TOBACCO; NITRATE REDUCING BACTERIUM; SEASONAL VARIATION; SHELF LIFE; SMOKELESS TOBACCO; STORAGE; TOBACCO; TOBACCO INDUSTRY; WEATHER;

NICOTIANA TABACUM;

EID: 84863399336     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.11.035     Document Type: Article

References (19)

1. Andersen R.A., Burton H.R., Fleming P.D., Hamilton-Kemp T.R., Gay S.L. Effects of air-curing environment on alkaloid-derived nitrosamines in burley tobacco. IARC Sci. Publ. 1987, (84):451-455.
2. Andersen R.A., Burton H.R., Fleming P.D., Hamilton-Kemp T.R. Effect of storage conditions on nitrosated, acylated, and oxidized pyridine alkaloid derivatives in smokeless tobacco products. Cancer Res. 1989, 49(21):5895-5900.
3. Bennett, C.B., Midgett, C.H., Johnston, K.S., Owen, J.K., Welden, J.C., Shanmugan, S.M., Franke, J.E., and Balasubramanian, S., 2002. An automated analytical method for determination of tobacco specific nitrosamines in tobacco; smoke science and product technology. Presentation No. 33 at 2002 CORESTA Congress, September 22-27, New Orleans, LA.
4. Brunnemann, K. D. Qi J. and Hoffmann D, 2001. Aging of oral moist snuff and the yields of tobacco-specific N-nitrosamines (TSNA). http://www.tobacco.org/News/010622BostonRe.html.
5. Brunnemann K.D., Hoffmann D. Analytical studies on tobacco-specific N-nitrosamines in tobacco and tobacco smoke. Crit. Rev. Toxicol. 1991, 21(4):235-240.
6. Brunnemann K.D., Prokopczyk B., Djordjevic M.V., Hoffmann D. Formation and analysis of tobacco-specific N-nitrosamines. Crit. Rev. Toxicol. 1996, 26(2):121-137.
7. Conn H.J., Jennison M.W., Weeks O.B. Routine tests for the identification of bacteria. Manual of Microbiological Methods 1957, 140-168. McGraw-Hill Book Co, New York. H.J. Conn (Ed.).
8. Djordjevic M.V., Fan J., Bush L.P., Brunnemann K.D., Hoffmann D. Effects of storage conditions on levels of tobacco-specific N-nitrosamines and N-sitrosamino acids in US moist snuff. J. Agric. Food. Chem. 1993, 41:1790-1794.
9. Harris, W.E., Gibson, S.M., Finch, J.N., Hart, F, Heltsley, D., Ray, C., Thorburn, T., 2009. Productivity improvements through chromatography and automation for GC/TEA TSNA analysis of tobacco leaf. Presentation No. 29 at the 62nd Tobacco Science Research Conference, September 9, Nashville, TN.
10. Hatsukami D.K., Ebbert J.O., Feuer R.M., Stepanov I., Hecht S.S. Changing smokeless tobacco products new tobacco-delivery systems. Am. J. Prev. Med. 2007, 33(Suppl. 6):S368-S378.
11. Hecht S.S., Stepanov I., Hatsukami D.K. Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products. Tob. Control 2010.
12. Hoffmann D., Djordjevic M.V. Chemical composition and carcinogenicity of smokeless tobacco. Adv. Dent. Res. 1997, 11(3):322-329.
13. Hoffmann D., Adams J.D., Brunnemann K.D., Rivenson A., Hecht S.S. Tobacco specific N-nitrosamines: occurrence and bioassays. IARC Sci. Publ. 1982, (41):309-318.
14. Hoffmann D., Djordjevic M.V., Fan J., Zang E., Glynn T., Connolly G.N. Five leading US commercial brands of moist snuff in 1994: assessment of carcinogenic N-nitrosamines. J. Natl Cancer Inst. 1995, 87(24):1862-1869.
15. International Agency for Research on Cancer, 2004. Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines, vol. 89. Lyon, France: IARC (IARC Monographs on the evaluation of carcinogenic risk of chemicals to humans).
16. Rodu B., Jansson C. Smokeless tobacco and oral cancer: a review of the risks and determinants. Crit. Rev. Oral Biol. Med. 2004, 15(5):252-263.
17. Stepanov I., Jensen J., Hatsukami D., Hecht S.S. Tobacco-specific nitrosamines in new tobacco products. Nicotine Tob. Res. 2006, 8(2):309-313.
18. US Surgeon General, 1986. The health consequences of using smokeless tobacco: A report of the Advisory Committee to the Surgeon General. Bethesda, MD: US Department of Health and Human Services; Public Health Service. NIH Publication No. 86-2874.
19. Wendt K. QuikChem Method 10-107-04-1-A: Determination of Nitrate/Nitrite in Surface and Wastewaters by Flow Injection Analysis 2000, Lachat Instruments, Milwaukee, WI.