Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide

Environmental Toxicology and Pharmacology

Volumn 33, Issue 2, 2012, Pages 205-211

  Zhu, Huifang ^a,b   Fan, Yanfeng ^a   Shen, Jing ^a   Qi, Hongyan ^a   Shao, Jimin ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

( ) anti Benzo a pyrene 7,8 diol 9,10 epoxide (BPDE); DNA polymerase (Pol ); Promoter; Translesion DNA synthesis (TLS)

Indexed keywords

DIHYDROXYBENZO[A]PYRENE OXIDE; DNA POLYMERASE; DNA POLYMERASE KAPPA; HEAT SHOCK TRANSCRIPTION FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CELL STRAIN; COMPUTER PREDICTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENOTOXICITY; HUMAN; HUMAN CELL; MARKER GENE; MOLECULAR CLONING; POLK GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE STUDY; REGULATORY SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BASE SEQUENCE; BINDING SITES; CARCINOGENS, ENVIRONMENTAL; CELLS, CULTURED; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DNA-DIRECTED DNA POLYMERASE; EPITHELIAL CELLS; GENES, REPORTER; HUMANS; LUCIFERASES, FIREFLY; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84863394735     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.12.002     Document Type: Article

References (23)

1. Akerfelt M., Trouillet D., Mezger V., Sistonen L. Heat shock factors at a crossroad between stress and development. Ann. N. Y. Acad. Sci. 2007, 1113:15-27.
2. Bavoux C., Hoffmann J.S., Cazaux C. Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa. Biochimie 2005, 87(7):637-646.
3. Bavoux C., Leopoldino A.M., Bergoglio V., O-Wang J., Ogi T., Bieth A., Judde J.G., Pena S.D., Poupon M.F., Helleday T., et al. Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. Cancer Res. 2005, 65(1):325-330.
4. Bi X., Barkley L.R., Slater D.M., Tateishi S., Yamaizumi M., Ohmori H., Vaziri C. Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest. Mol. Cell. Biol. 2006, 26(9):3527-3540.
5. Bi X., Slater D.M., Ohmori H., Vaziri C. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. J. Biol. Chem. 2005, 280(23):22343-22355.
6. Carlson K.D., Johnson R.E., Prakash L., Prakash S., Washington M.T. Human DNA polymerase kappa forms nonproductive complexes with matched primer termini but not with mismatched primer termini. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(43):15776-15781.
7. Chiapperino D., Cai M., Sayer J.M., Yagi H., Kroth H., Masutani C., Hanaoka F., Jerina D.M., Cheh A.M. Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. J. Biol. Chem. 2005, 280(48):39684-39692.
8. Friedberg E.C., Lehmann A.R., Fuchs R.P. Trading places: how do DNA polymerases switch during translesion DNA synthesis?. Mol. Cell 2005, 18(5):499-505.
9. Guettouche T., Boellmann F., Lane W.S., Voellmy R. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem. 2005, 6:4.
10. Hockley S.L., Arlt V.M., Brewer D., Te Poele R., Workman P., Giddings I., Phillips D.H. AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem. Res. Toxicol. 2007, 20(12):1797-1810.
11. Jarosz D.F., Godoy V.G., Walker G.C. Proficient and accurate bypass of persistent DNA lesions by DinB DNA polymerases. Cell Cycle 2007, 6(7):817-822.
12. Lemee F., Bavoux C., Pillaire M.J., Bieth A., Machado C.R., Pena S.D., Guimbaud R., Selves J., Hoffmann J.S., Cazaux C. Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer. Oncogene 2007, 26(23):3387-3394.
13. Lu X., Shao J., Li H., Yu Y. Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line. Genomics 2009, 93(4):332-342.
14. Lu X., Shao J., Li H., Yu Y. Temporal gene expression changes induced by a low concentration of benzo[a]pyrene diol epoxide in a normal human cell line. Mutat. Res. 2010, 684(1-2):74-80.
15. Ogi T., Lehmann A.R. The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair. Nat. Cell Biol. 2006, 8(6):640-642.
16. Safe S., Abdelrahim M. Sp transcription factor family and its role in cancer. Eur. J. Cancer 2005, 41(16):2438-2448.
17. Sherrer S.M., Fiala K.A., Fowler J.D., Newmister S.A., Pryor J.M., Suo Z. Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases. Nucleic Acids Res. 2011, 39(2):609-622.
18. Vasquez-Del Carpio R., Silverstein T.D., Lone S., Johnson R.E., Prakash L., Prakash S., Aggarwal A.K. Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer. J. Mol. Biol. 2011, 408(2):252-261.
19. Wang G., Yu Y., Chen X., Xie H. Low concentration N-methyl-N'-nitro-N-nitrosoguanidine activates DNA polymerase-beta expression via cyclic-AMP-protein kinase A-cAMP response element binding protein pathway. Mutat. Res. 2001, 478(1-2):177-184.
20. Wang Q., Jiang H., Fan Y., Huang X., Shen J., Qi H., Li Q., Lu X., Shao J. Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) alleviates benzo[a]pyrene-7,8-diol-9,10-epoxide induced cell cycle arrest and apoptosis in human cells. Environ. Toxicol. Pharmacol. 2011, 31(1):18-24.
21. Westerheide S.D., Anckar J., Stevens S.M., Sistonen L., Morimoto R.I. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009, 323(5917):1063-1066.
22. Yang Y., Li Z. Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?. Mol. Cells 2005, 20(2):173-182.
23. Zhu H., Fan Y., Jiang H., Shen J., Qi H., Mei R., Shao J. Response of human DNA polymerase iota promoter to N-methyl-N'-nitro-N-nitrosoguanidine. Environ. Toxicol. Pharmacol. 2010, 29(1):79-86.