Phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) alleviates benzo[a]pyrene-7,8-diol-9,10-epoxide induced cell cycle arrest and apoptosis in human cells

Environmental Toxicology and Pharmacology

Volumn 31, Issue 1, 2011, Pages 18-24

  Wang, Qiaoling ^a   Jiang, Hongjuan ^a   Fan, Yanfeng ^a   Huang, Xiaobin ^a   Shen, Jing ^a   Qi, Hongyan ^a   Li, Qian ^a   Lu, Xiangyun ^a   Shao, Jimin ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Benzo a pyrene 7,8 diol 9,10 epoxide (BPDE); Cell cycle arrest; Cellular stress response; EIF2 phosphorylation

Indexed keywords

7,8 DIHYDROXYBENZO[A]PYRENE 9,10 OXIDE; ACTIVATING TRANSCRIPTION FACTOR 4; EUKARYOTIC INITIATION FACTOR 2ALPHA KINASE 1; EUKARYOTIC INITIATION FACTOR 2ALPHA KINASE 3; EUKARYOTIC INITIATION FACTOR 2ALPHA KINASE 4; INITIATION FACTOR 2ALPHA; PROTEIN KINASE; PROTEIN KINASE R; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DAMAGE; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEFENSE MECHANISM; DEPHOSPHORYLATION; DNA DAMAGE; DNA FRAGMENTATION; DOSE TIME EFFECT RELATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL SURVIVAL; EUKARYOTIC INITIATION FACTOR-2; FLOW CYTOMETRY; HUMANS; MUTAGENS; PHOSPHORYLATION;

EUKARYOTA;

EID: 78650219646     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.08.005     Document Type: Article

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