Pulmonary hypertension associated with advanced systolic heart failure: Dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1

Journal of the American College of Cardiology

Volumn 59, Issue 13, 2012, Pages 1150-1158

  Shao, Zhili ^a   Wang, Zeneng ^a   Shrestha, Kevin ^a   Thakur, Akanksha ^b   Borowski, Allen G ^a   Sweet, Wendy ^a   Thomas, James D ^a   Moravec, Christine S ^a   Hazen, Stanley L ^a   Tang, W H Wilson ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

asymmetric dimethylarginine; heart failure; nitric oxide synthase; pulmonary hypertension

Indexed keywords

ARGININE; DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; METHYLTRANSFERASE; N(G),N(G) DIMETHYLARGININE; PROTEIN METHYLTRANSFERASE 1; UNCLASSIFIED DRUG;

ADULT; ADVANCED SYSTOLIC HEART FAILURE; AGED; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEART HEMODYNAMICS; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; LUNG ARTERY PRESSURE; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PULMONARY ARTERY OCCLUSION PRESSURE; PULMONARY HYPERTENSION; SYSTOLIC HEART FAILURE; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATE;

AGED; AMIDOHYDROLASES; ARGININE; DISEASE PROGRESSION; FEMALE; HEART FAILURE, SYSTOLIC; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED;

EID: 84863392134     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.12.022     Document Type: Article

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