메뉴 건너뛰기




Volumn 6, Issue 2, 2010, Pages 215-222

Heart Failure and Pulmonary Hypertension

Author keywords

BMPR2; Heart failure; Nitric oxide; PDE5; Pulmonary hypertension

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; PHOSPHODIESTERASE V; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77950218243     PISSN: 15517136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hfc.2009.11.007     Document Type: Review
Times cited : (12)

References (54)
  • 1
    • 0037058826 scopus 로고    scopus 로고
    • Lifetime risk for developing congestive heart failure: the Framingham Heart Study
    • Lloyd-Jones D.M., Larson M.G., Leip E.P., et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 106 (2002) 3068
    • (2002) Circulation , vol.106 , pp. 3068
    • Lloyd-Jones, D.M.1    Larson, M.G.2    Leip, E.P.3
  • 2
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D., Adams R., Carnethon M., et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119 (2009) 480
    • (2009) Circulation , vol.119 , pp. 480
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3
  • 3
    • 0035165175 scopus 로고    scopus 로고
    • Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure
    • Ghio S., Gavazzi A., Campana C., et al. Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol 37 (2001) 183
    • (2001) J Am Coll Cardiol , vol.37 , pp. 183
    • Ghio, S.1    Gavazzi, A.2    Campana, C.3
  • 4
    • 0037323595 scopus 로고    scopus 로고
    • Response of the right ventricle to acute pulmonary vasodilation predicts the outcome in patients with advanced heart failure and pulmonary hypertension
    • Gavazzi A., Ghio S., Scelsi L., et al. Response of the right ventricle to acute pulmonary vasodilation predicts the outcome in patients with advanced heart failure and pulmonary hypertension. Am Heart J 145 (2003) 310
    • (2003) Am Heart J , vol.145 , pp. 310
    • Gavazzi, A.1    Ghio, S.2    Scelsi, L.3
  • 5
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G., Galie N., Rubin L.J., et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 43 (2004) 5S
    • (2004) J Am Coll Cardiol , vol.43
    • Simonneau, G.1    Galie, N.2    Rubin, L.J.3
  • 6
    • 0031031440 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin L.J. Primary pulmonary hypertension. N Engl J Med 336 (1997) 111
    • (1997) N Engl J Med , vol.336 , pp. 111
    • Rubin, L.J.1
  • 7
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber H.W., and Loscalzo J. Pulmonary arterial hypertension. N Engl J Med 351 (2004) 1655
    • (2004) N Engl J Med , vol.351 , pp. 1655
    • Farber, H.W.1    Loscalzo, J.2
  • 8
    • 0034804681 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Fishman A.P. Clinical classification of pulmonary hypertension. Clin Chest Med 22 (2001) 385
    • (2001) Clin Chest Med , vol.22 , pp. 385
    • Fishman, A.P.1
  • 9
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension. A national prospective study
    • Rich S., Dantzker D.R., Ayres S.M., et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 107 (1987) 216
    • (1987) Ann Intern Med , vol.107 , pp. 216
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 10
    • 27144522525 scopus 로고    scopus 로고
    • Characterization of brain natriuretic peptide in long-term follow-up of pulmonary arterial hypertension
    • Leuchte H.H., Holzapfel M., Baumgartner R.A., et al. Characterization of brain natriuretic peptide in long-term follow-up of pulmonary arterial hypertension. Chest 128 (2005) 2368
    • (2005) Chest , vol.128 , pp. 2368
    • Leuchte, H.H.1    Holzapfel, M.2    Baumgartner, R.A.3
  • 11
    • 0037623284 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Runo J.R., and Loyd J.E. Primary pulmonary hypertension. Lancet 361 (2003) 1533
    • (2003) Lancet , vol.361 , pp. 1533
    • Runo, J.R.1    Loyd, J.E.2
  • 12
    • 0027200632 scopus 로고
    • Primary pulmonary hypertension
    • Rubin L.J. Primary pulmonary hypertension. Chest 104 (1993) 236
    • (1993) Chest , vol.104 , pp. 236
    • Rubin, L.J.1
  • 13
    • 57449105233 scopus 로고    scopus 로고
    • Diagnosis and treatment of secondary (non-category 1) pulmonary hypertension
    • Rich S., and Rabinovitch M. Diagnosis and treatment of secondary (non-category 1) pulmonary hypertension. Circulation 118 (2008) 2190
    • (2008) Circulation , vol.118 , pp. 2190
    • Rich, S.1    Rabinovitch, M.2
  • 14
    • 33847634329 scopus 로고    scopus 로고
    • Pulmonary hypertension associated with left-sided heart disease
    • Oudiz R.J. Pulmonary hypertension associated with left-sided heart disease. Clin Chest Med 28 (2007) 233
    • (2007) Clin Chest Med , vol.28 , pp. 233
    • Oudiz, R.J.1
  • 15
    • 0033571486 scopus 로고    scopus 로고
    • Pulmonary hypertension and exercise intolerance in patients with heart failure
    • Butler J., Chomsky D.B., and Wilson J.R. Pulmonary hypertension and exercise intolerance in patients with heart failure. J Am Coll Cardiol 34 (1999) 1802
    • (1999) J Am Coll Cardiol , vol.34 , pp. 1802
    • Butler, J.1    Chomsky, D.B.2    Wilson, J.R.3
  • 16
    • 62549141018 scopus 로고    scopus 로고
    • Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study
    • Lam C.S., Roger V.L., Rodeheffer R.J., et al. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol 53 (2009) 1119
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1119
    • Lam, C.S.1    Roger, V.L.2    Rodeheffer, R.J.3
  • 17
    • 0028931284 scopus 로고
    • Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure
    • Di Salvo T.G., Mathier M., Semigran M.J., et al. Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol 25 (1995) 1143
    • (1995) J Am Coll Cardiol , vol.25 , pp. 1143
    • Di Salvo, T.G.1    Mathier, M.2    Semigran, M.J.3
  • 18
    • 0028070791 scopus 로고
    • Hemodynamic effects of inhaled nitric oxide in heart failure
    • Semigran M.J., Cockrill B.A., Kacmarek R., et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol 24 (1994) 982
    • (1994) J Am Coll Cardiol , vol.24 , pp. 982
    • Semigran, M.J.1    Cockrill, B.A.2    Kacmarek, R.3
  • 19
    • 0032526143 scopus 로고    scopus 로고
    • Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction
    • Koelling T.M., Kirmse M., Di Salvo T.G., et al. Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction. Am J Cardiol 81 (1998) 1494
    • (1998) Am J Cardiol , vol.81 , pp. 1494
    • Koelling, T.M.1    Kirmse, M.2    Di Salvo, T.G.3
  • 20
    • 33846099444 scopus 로고    scopus 로고
    • Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    • Lewis G.D., Lachmann J., Camuso J., et al. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation 115 (2007) 59
    • (2007) Circulation , vol.115 , pp. 59
    • Lewis, G.D.1    Lachmann, J.2    Camuso, J.3
  • 21
    • 34848914106 scopus 로고    scopus 로고
    • Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    • Lewis G.D., Shah R., Shahzad K., et al. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation 116 (2007) 1555
    • (2007) Circulation , vol.116 , pp. 1555
    • Lewis, G.D.1    Shah, R.2    Shahzad, K.3
  • 22
    • 41249101721 scopus 로고    scopus 로고
    • Effects of 5′-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial
    • Behling A., Rohde L.E., Colombo F.C., et al. Effects of 5′-phosphodiesterase four-week long inhibition with sildenafil in patients with chronic heart failure: a double-blind, placebo-controlled clinical trial. J Card Fail 14 (2008) 189
    • (2008) J Card Fail , vol.14 , pp. 189
    • Behling, A.1    Rohde, L.E.2    Colombo, F.C.3
  • 23
    • 36148948551 scopus 로고    scopus 로고
    • Long-term use of sildenafil in the therapeutic management of heart failure
    • Guazzi M., Samaja M., Arena R., et al. Long-term use of sildenafil in the therapeutic management of heart failure. J Am Coll Cardiol 50 (2007) 2136
    • (2007) J Am Coll Cardiol , vol.50 , pp. 2136
    • Guazzi, M.1    Samaja, M.2    Arena, R.3
  • 24
    • 0038042038 scopus 로고    scopus 로고
    • Endothelin receptor blockade and exacerbation of heart failure
    • Szokodi I., Piuhola J., and Ruskoaho H. Endothelin receptor blockade and exacerbation of heart failure. Circulation 107 (2003) e211
    • (2003) Circulation , vol.107
    • Szokodi, I.1    Piuhola, J.2    Ruskoaho, H.3
  • 25
    • 3242810591 scopus 로고    scopus 로고
    • Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial
    • Anand I., McMurray J., Cohn J.N., et al. Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet 364 (2004) 347
    • (2004) Lancet , vol.364 , pp. 347
    • Anand, I.1    McMurray, J.2    Cohn, J.N.3
  • 26
    • 20844459311 scopus 로고    scopus 로고
    • Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study
    • Packer M., McMurray J., Massie B.M., et al. Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study. J Card Fail 11 (2005) 12
    • (2005) J Card Fail , vol.11 , pp. 12
    • Packer, M.1    McMurray, J.2    Massie, B.M.3
  • 27
    • 0030853952 scopus 로고    scopus 로고
    • A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST)
    • Califf R.M., Adams K.F., McKenna W.J., et al. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST). Am Heart J 134 (1997) 44
    • (1997) Am Heart J , vol.134 , pp. 44
    • Califf, R.M.1    Adams, K.F.2    McKenna, W.J.3
  • 28
    • 20044363270 scopus 로고    scopus 로고
    • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
    • Takimoto E., Champion H.C., Li M., et al. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 11 (2005) 214
    • (2005) Nat Med , vol.11 , pp. 214
    • Takimoto, E.1    Champion, H.C.2    Li, M.3
  • 29
    • 0034727717 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: a vascular biology and translational research "Work in progress
    • Archer S., and Rich S. Primary pulmonary hypertension: a vascular biology and translational research "Work in progress. Circulation 102 (2000) 2781
    • (2000) Circulation , vol.102 , pp. 2781
    • Archer, S.1    Rich, S.2
  • 30
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder R.M., Groves B., Badesch D.B., et al. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 144 (1994) 275
    • (1994) Am J Pathol , vol.144 , pp. 275
    • Tuder, R.M.1    Groves, B.2    Badesch, D.B.3
  • 31
    • 0034772039 scopus 로고    scopus 로고
    • Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
    • Tuder R.M., Chacon M., Alger L., et al. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 195 (2001) 367
    • (2001) J Pathol , vol.195 , pp. 367
    • Tuder, R.M.1    Chacon, M.2    Alger, L.3
  • 32
    • 0032031727 scopus 로고    scopus 로고
    • Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension
    • Lee S.D., Shroyer K.R., Markham N.E., et al. Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest 101 (1998) 927
    • (1998) J Clin Invest , vol.101 , pp. 927
    • Lee, S.D.1    Shroyer, K.R.2    Markham, N.E.3
  • 33
    • 0032433228 scopus 로고    scopus 로고
    • Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension
    • Tuder R.M., Radisavljevic Z., Shroyer K.R., et al. Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension. Am J Respir Crit Care Med 158 (1998) 1999
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1999
    • Tuder, R.M.1    Radisavljevic, Z.2    Shroyer, K.R.3
  • 34
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng Z., Morse J.H., Slager S.L., et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 67 (2000) 737
    • (2000) Am J Hum Genet , vol.67 , pp. 737
    • Deng, Z.1    Morse, J.H.2    Slager, S.L.3
  • 35
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium
    • Lane K.B., Machado R.D., Pauciulo M.W., et al. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet 26 (2000) 81
    • (2000) Nat Genet , vol.26 , pp. 81
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3
  • 36
    • 0033623296 scopus 로고    scopus 로고
    • Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family
    • Thomson J.R., Machado R.D., Pauciulo M.W., et al. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. J Med Genet 37 (2000) 741
    • (2000) J Med Genet , vol.37 , pp. 741
    • Thomson, J.R.1    Machado, R.D.2    Pauciulo, M.W.3
  • 37
    • 0035163071 scopus 로고    scopus 로고
    • BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
    • Machado R.D., Pauciulo M.W., Thomson J.R., et al. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet 68 (2001) 92
    • (2001) Am J Hum Genet , vol.68 , pp. 92
    • Machado, R.D.1    Pauciulo, M.W.2    Thomson, J.R.3
  • 38
    • 0035797529 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • Newman J.H., Wheeler L., Lane K.B., et al. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345 (2001) 319
    • (2001) N Engl J Med , vol.345 , pp. 319
    • Newman, J.H.1    Wheeler, L.2    Lane, K.B.3
  • 39
    • 0028171579 scopus 로고
    • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
    • McAllister K.A., Grogg K.M., Johnson D.W., et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 8 (1994) 345
    • (1994) Nat Genet , vol.8 , pp. 345
    • McAllister, K.A.1    Grogg, K.M.2    Johnson, D.W.3
  • 40
    • 0030050973 scopus 로고    scopus 로고
    • Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
    • Johnson D.W., Berg J.N., Baldwin M.A., et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 13 (1996) 189
    • (1996) Nat Genet , vol.13 , pp. 189
    • Johnson, D.W.1    Berg, J.N.2    Baldwin, M.A.3
  • 41
    • 0037421604 scopus 로고    scopus 로고
    • Signaling molecules in nonfamilial pulmonary hypertension
    • Du L., Sullivan C.C., Chu D., et al. Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 348 (2003) 500
    • (2003) N Engl J Med , vol.348 , pp. 500
    • Du, L.1    Sullivan, C.C.2    Chu, D.3
  • 42
    • 0034074899 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
    • Dorai H., Vukicevic S., and Sampath T.K. Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol 184 (2000) 37
    • (2000) J Cell Physiol , vol.184 , pp. 37
    • Dorai, H.1    Vukicevic, S.2    Sampath, T.K.3
  • 43
    • 0031470417 scopus 로고    scopus 로고
    • Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
    • Nakaoka T., Gonda K., Ogita T., et al. Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2. J Clin Invest 100 (1997) 2824
    • (1997) J Clin Invest , vol.100 , pp. 2824
    • Nakaoka, T.1    Gonda, K.2    Ogita, T.3
  • 44
    • 0032924166 scopus 로고    scopus 로고
    • BMP-2 gene expression and effects on human vascular smooth muscle cells
    • Willette R.N., Gu J.L., Lysko P.G., et al. BMP-2 gene expression and effects on human vascular smooth muscle cells. J Vasc Res 36 (1999) 120
    • (1999) J Vasc Res , vol.36 , pp. 120
    • Willette, R.N.1    Gu, J.L.2    Lysko, P.G.3
  • 45
    • 0035032914 scopus 로고    scopus 로고
    • Divergence and convergence of TGF-beta/BMP signaling
    • Miyazono K., Kusanagi K., and Inoue H. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 187 (2001) 265
    • (2001) J Cell Physiol , vol.187 , pp. 265
    • Miyazono, K.1    Kusanagi, K.2    Inoue, H.3
  • 46
    • 0034551683 scopus 로고    scopus 로고
    • Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2
    • Yamada M., Revelli J.P., Eichele G., et al. Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev Biol 228 (2000) 95
    • (2000) Dev Biol , vol.228 , pp. 95
    • Yamada, M.1    Revelli, J.P.2    Eichele, G.3
  • 47
    • 1642402120 scopus 로고    scopus 로고
    • The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
    • Brown III C.O., Chi X., Garcia-Gras E., et al. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem 279 (2004) 10659
    • (2004) J Biol Chem , vol.279 , pp. 10659
    • Brown III, C.O.1    Chi, X.2    Garcia-Gras, E.3
  • 48
    • 0037250476 scopus 로고    scopus 로고
    • Consequences of knocking out BMP signaling in the mouse
    • Zhao G.Q. Consequences of knocking out BMP signaling in the mouse. Genesis 35 (2003) 43
    • (2003) Genesis , vol.35 , pp. 43
    • Zhao, G.Q.1
  • 49
    • 0035139719 scopus 로고    scopus 로고
    • Bone morphogenetic protein function is required for terminal differentiation of the heart but not for early expression of cardiac marker genes
    • Walters M.J., Wayman G.A., and Christian J.L. Bone morphogenetic protein function is required for terminal differentiation of the heart but not for early expression of cardiac marker genes. Mech Dev 100 (2001) 263
    • (2001) Mech Dev , vol.100 , pp. 263
    • Walters, M.J.1    Wayman, G.A.2    Christian, J.L.3
  • 50
    • 21644447416 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells
    • Yu P.B., Beppu H., Kawai N., et al. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem 280 (2005) 24443
    • (2005) J Biol Chem , vol.280 , pp. 24443
    • Yu, P.B.1    Beppu, H.2    Kawai, N.3
  • 51
    • 0034193390 scopus 로고    scopus 로고
    • BMP type II receptor is required for gastrulation and early development of mouse embryos
    • Beppu H., Kawabata M., Hamamoto T., et al. BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221 (2000) 249
    • (2000) Dev Biol , vol.221 , pp. 249
    • Beppu, H.1    Kawabata, M.2    Hamamoto, T.3
  • 52
    • 8644256840 scopus 로고    scopus 로고
    • BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia
    • Beppu H., Ichinose F., Kawai N., et al. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 287 (2004) L1241
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Beppu, H.1    Ichinose, F.2    Kawai, N.3
  • 53
    • 23044504042 scopus 로고    scopus 로고
    • Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice
    • Song Y., Jones J.E., Beppu H., et al. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112 (2005) 553
    • (2005) Circulation , vol.112 , pp. 553
    • Song, Y.1    Jones, J.E.2    Beppu, H.3
  • 54
    • 2342486700 scopus 로고    scopus 로고
    • Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle
    • West J., Fagan K., Steudel W., et al. Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94 (2004) 1109
    • (2004) Circ Res , vol.94 , pp. 1109
    • West, J.1    Fagan, K.2    Steudel, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.