Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures

Journal of Molecular Neuroscience

Volumn 46, Issue 1, 2012, Pages 153-161

  Wang, Fang ^a   Zhai, Heng ^a   Huang, Luqi ^a   Li, Hui ^a   Xu, Yan ^a   Qiao, Xian ^a   Sun, Shenggang ^a   Wu, Yan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ASA; Inflammation; Microglia; NADPH oxidase; Neurodegeneration; Parkinson's disease

Indexed keywords

ACETYLSALICYLIC ACID; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; INFLAMMATION; MESENCEPHALON; MICROGLIA; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PREMEDICATION; RAT; DRUG INHIBITION; EMBRYO; GLIA CELL; INHIBITION KINETICS; NERVE CELL; NEUROTOXICITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; ASTROCYTES; COCULTURE TECHNIQUES; DOPAMINERGIC NEURONS; ENCEPHALITIS; LIPOPOLYSACCHARIDES; MESENCEPHALON; MICROGLIA; NADH, NADPH OXIDOREDUCTASES; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; OXIDATIVE STRESS; PRIMARY CELL CULTURE; RATS; SUPEROXIDES;

EID: 84863384325     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9541-3     Document Type: Article

References (28)

1. Akiyama H, McGeer PL (1989) Microglial response to 6-hydroxydopamine- induced substantia nigra lesions. Brain Res 489:247-253 (Pubitemid 19149247)
2. Ariza D, Lima MM, Moreira CG et al (2010) Intranigral LPS administration produces dopamine, glutathione but not behavioral impairment in comparison to MPTP and 6-OHDA neurotoxin models of Parkinson's disease. Neurochem Res 35:1620-1627
3. Brochard V, Combadiere B, Prigent A et al (2009) Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Investig 119:182-192
4. DeLeo FR, Quinn MT (1996) Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol 60:677-691 (Pubitemid 27041655)
5. Di Matteo V, Benigno A, Pierucci M et al (2006a) 7-Nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. Ann NY Acad Sci 1089:462-471 (Pubitemid 47092070)
6. Di Matteo V, Pierucci M, Di Giovanni G et al (2006b) Aspirin protects striatal dopaminergic neurons from neurotoxin-induced degeneration: an in vivo microdialysis study. Brain Res 1095:167-177 (Pubitemid 43884742)
7. Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B (2002) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 81:1285-1297 (Pubitemid 34809262)
8. Gao HM, Hong JS, Zhang W, Liu B (2003a) Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J Neurosci 23:1228-1236 (Pubitemid 36258901)
9. Gao HM, Liu B, Zhang W, Hong JS (2003b) Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J 17:1954-1956
10. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918-934
11. Graeber MB, Streit WJ (2010) Microglia: biology and pathology. Acta Neuropathol 119:89-105
12. Grili M, Pizzi M, Memo M, Spano P (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274:1383-1385, New York, N.Y (Pubitemid 26391464)
13. Hams AS, Barnum CJ, Ruhn KA et al (2011) Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. Mol Ther 19:46-52
14. Ishida Y, Nagai A, Kobayashi S, Kim SU (2006) Upregulation of protease-activated receptor-1 in astrocytes in Parkinson's disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase. J Neuropathol Exp Neurol 65:66-77
15. Kim YS, Joh TH (2006) Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp Mol Med 38:333-347 (Pubitemid 44390511)
16. Lavigne MC, Malech HL, Holland SM, Leto TL (2001) Genetic requirement of p47phox for superoxide production by murine microglia. FASEB J 15:285-287
17. Li JM, Mullen AM, Yun S et al (2002) Essential role of the NADPH oxidase subunit p47 (phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha. Circ Res 90:143-150 (Pubitemid 34627082)
18. Liu B, Hong JS (2003) Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304:1-7 (Pubitemid 36008905)
19. Maharaj DS, Saravanan KS, Maharaj H, Mohanakumar KP, Daya S (2004) Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Neurochem Int 44:355-360 (Pubitemid 37485867)
20. McCoy MK, Martinez TN, Ruhn KA et al (2006) Blocking soluble tumor necrosis factor signaling with dominant-negative TNF inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci 26:9365-9375 (Pubitemid 44396849)
21. Miller R, Sun G, Sun A (2007) Cytotoxicity of paraquat in microglial cells: involvement of the PKC delta- and ERK1/2-dependent NADPH oxidase. Brain Res 1167:129-139 (Pubitemid 47302435)
22. Qian L, Block ML, Wei SJ et al (2006) Interleukin-10 protects lipopolysaccharide induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. J Pharmacol Exp Ther 319:44-52 (Pubitemid 44455109)
23. Qian L, Wei SJ, Zhang D et al (2008) Potent anti-inflammatory and neuroprotective of TGF-beta1 are mediated through the inhibition of ERK and P47phox-Ser345 phosphorylation and translocation in microglia. J Immunol 181:660-668
24. Qin L, Liu Y, Wang T et al (2004) NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 279:1415-1421 (Pubitemid 38082669)
25. Riederer P, Wuketich S (1976) Time course of nigrostriatal degeneration in Parkinson's disease. A detailed study of influential factors in human brain amine analysis. J Neural Transm 38:227-301
26. Savitt JM, Dawson VL, Dawson TM (2006) Diagnosis and treatment of Parkinson's disease: molecules to medicine. J Clin Investig 116:1744-1754 (Pubitemid 44033293)
27. 2 and NO on apoptosis involving activation of P38 mitogen-activated protein kinase and caspase-3. J Neurosci Res 72:508-519
28. Wilms H, Zecca L, Rosenstiel P, Sievers J, Deuschl G, Lucicus R (2007) Inflammation in Parkinson's disease and other neurodegenerative disease: cause and therapeutic implications. Curr Pharm Des 13:1925-1928 (Pubitemid 47017994)