TGF-β1 downregulates AT1 receptor expression via PKC-δ-mediated Sp1 dissociation from KLF4 and smad-mediated PPAR-γ association with KLF4

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 4, 2012, Pages 1015-1023

  Zhang, Xin Hua ^a   Zheng, Bin ^a   Gu, Chun ^a   Fu, Jian Ran ^a   Wen, Jin Kun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

KLF4; PPAR ; Sp1; Vascular biology; vascular smooth muscle cells

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANGIOTENSIN 1 RECEPTOR; KRUPPEL LIKE FACTOR 4; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SERINE; SMAD PROTEIN; THREONINE;

ARTICLE; BINDING SITE; CARDIOVASCULAR EFFECT; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; DOWN REGULATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; GENES, REPORTER; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C-DELTA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RNA INTERFERENCE; RNA, MESSENGER; SERINE; SMAD PROTEINS; SP1 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84863367020     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.244962     Document Type: Article

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