Effects of add-on therapy with NDC-052, an extract from Magnoliae flos, in adult asthmatic patients receiving inhaled corticosteroids

Korean Journal of Internal Medicine

Volumn 27, Issue 1, 2012, Pages 84-90

  Park, Chan Sun ^a   Kim, Tae Bum ^b   Lee, Jae Young ^c   Park, Jae Yong ^d   Lee, Yong Chul ^e   Jeong, Seong Su ^f   Lee, Yang Deok ^g   Cho, You Sook ^b   Moon, Hee Bom ^b  

^a Inje University College of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Hallym University College of Medicine   (South Korea)

^d Kyungpook National University Hospital   (South Korea)

^e Chonbuk National University Medical School   (South Korea)

^f Chungnam National University College of Medicine   (South Korea)

^g Eulji University School of Medicine   (South Korea)

Author keywords

Asthma; Chinese herbal; Drugs; Magnoliae; Magnolin

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; MAGNOLIA EXTRACT; NDC 052; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADD ON THERAPY; ADULT; AGED; ARTICLE; ASTHMA; CONSTIPATION; DISEASE SEVERITY; DRUG ERUPTION; DRUG SAFETY; DRUG TOLERABILITY; DRUG USE; DYSPHAGIA; DYSPNEA; EPIGASTRIC PAIN; EPIGASTRIC SORENESS; FACE DISORDER; FACIAL SWELLING; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INDIGESTION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MULTICENTER STUDY; MYALGIA; NAUSEA; PARESTHESIA; PEAK EXPIRATORY FLOW; PROSPECTIVE STUDY; PRURITUS; SCORING SYSTEM; SKIN EXFOLIATION; URTICARIA; VISUAL ANALOG SCALE; VOMITING; WAKEFULNESS;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG; MAGNOLIA; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; PROSPECTIVE STUDIES; REPUBLIC OF KOREA; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84863360439     PISSN: 12263303     EISSN: 20056648     Source Type: Journal    
DOI: 10.3904/kjim.2012.27.1.84     Document Type: Article

References (29)

1. Barnes PJ, Jonsson B, Klim JB. The costs of asthma. Eur Respir J 1996;9:636-642.
2. Masoli M, Fabian D, Holt S, Beasley R; Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-478.
3. National Institutes of Health, National Heart, Lung, and Blood Institute. National asthma education and prevention program: global strategy for asthma management and prevention. Global Initiative for Asthma report [Internet]. National Institutes of Health, National Heart, Lung, and Blood Institute, 2009 [cited 2011 Dec 20]. Available from http://www.ginasthma.org.
4. Jang AS. Inhaled steroids in asthma therapy: an update. Korean J Med 2011;80:129-134.
5. Visser MJ, van der Veer E, Postma DS, et al. Side-effects of fluticasone in asthmatic children: no effects after dose reduction. Eur Respir J 2004;24:420-425.
6. Eid N, Morton R, Olds B, Clark P, Sheikh S, Looney S. Decreased morning serum cortisol levels in children with asthma treated with inhaled fluticasone propionate. Pediatrics 2002;109:217-221.
7. Casale TB, Nelson HS, Stricker WE, Raff H, Newman KB. Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients. Ann Allergy Asthma Immunol 2001;87:379-385.
8. Li XM. Traditional Chinese herbal remedies for asthma and food allergy. J Allergy Clin Immunol 2007;120:25-31.
9. Shen Y, Li CG, Zhou SF, Pang EC, Story DF, Xue CC. Chemistry and bioactivity of Flos Magnoliae, a Chinese herb for rhinitis and sinusitis. Curr Med Chem 2008;15:1616-1627.
10. Chen CC, Huang YL, Chen HT, Chen YP, Hsu HY. On the Ca++-antagonistic principles of the flower buds of Magnolia fargesii. Planta Med 1988;54:438-440.
11. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-811.
12. Ahn KS, Jung KY, Kim JH, Oh SR, Lee HK. Inhibitory activity of lignin components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules. Biol Pharm Bull 2001;24:1085-1087.
13. Baek JA, Lee YD, Lee CB, et al. Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells. Nitric Oxide 2009;20:122-128.
14. Brightling CE, Monterio W, Green RH, et al. Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability. Respir Med 2001;95:999-1002.
15. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Noneosinophilic corticosteroid unresponsive asthma. Lancet 1999;353:2213-2214.
16. The Uppsala Monitoring Centre. The use of the WHO-UMC system for standardized case causality assessment [Internet]. Uppsala: The Uppsala Monitoring Centre, 2010 [cited 2011 Dec 20]. Available from: http://who-umc.org/Graphics/24734.pdf.
17. Bielory L, Lupoli K. Herbal interventions in asthma and allergy. J Asthma 1999;36:1-65.
18. Li XM, Zhang TF, Sampson H, et al. The potential use of Chinese herbal medicines in treating allergic asthma. Ann Allergy Asthma Immunol 2004;93(2 Suppl 1):S35-S44.
19. Iida T, Nakano M, Ito K. Hydroperoxysesquiterpene and lignan constituents of Magnolia kobus. Phytochemistry 1982;21:673-675.
20. Pan JX, Hensens OD, Zink DL, Chang MN, Hwang SB. Lignans with platelet activating factor antagonist activity from Magnolia biondii. Phytochemistry 1987;26:1377-1379.
21. Chae SH, Kim PS, Cho JY, et al. Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii. Arch Pharm Res 1998;21:67-69.
22. Huang YL, Chen CC, Chen YP, Hsu HY, Kuo YH. (-)-Fargesol, a new lignan from the flowers buds of Magnolia fargesii. Planta Med 1990;56:237-238.
23. Jung KY, Oh SR, Park SH, et al. Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii. Biol Pharm Bull 1998;21:1077-1078.
24. Kim HM, Yi JM, Lim KS. Magnoliae flos inhibits mast celldependent immediate-type allergic reactions. Pharmacol Res 1999;39:107-111.
25. Price DB, Hernandez D, Magyar P, et al. Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthma. Thorax 2003;58:211-216.
26. Vaquerizo MJ, Casan P, Castillo J, et al. Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma. Thorax 2003;58:204-210.
27. Barnes PJ, Pedersen S, Busse WW. Efficacy and safety of inhaled corticosteroids: new developments. Am J Respir Crit Care Med 1998;157(3 Pt 2):S1-S53.
28. Holt S, Suder A, Weatherall M, Cheng S, Shirtcliffe P, Beasley R. Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis. BMJ 2001;323:253-256.
29. Vanacker NJ, Palmans E, Pauwels RA, Kips JC. Effect of combining salmeterol and fluticasone on the progression of airway remodeling. Am J Respir Crit Care Med 2002;166:1128-1134.