The relationship between attention and gait in aging: Facts and fallacies

Motor Control

Volumn 16, Issue 1, 2012, Pages 64-80

  Holtzer, Roee ^a   Wang, Cuiling ^a   Verghese, Joe ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Gerontology; Motor control

Indexed keywords

AGED; AGING; ARTICLE; ATTENTION; CADENCE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMENTIA; EXECUTIVE ATTENTION; FEMALE; GAIT; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEMORY; MOTOR CONTROL; QUANTITATIVE ANALYSIS; STRIDE LENGTH; VELOCITY; WALKING;

EID: 84863359711     PISSN: 10871640     EISSN: 15432696     Source Type: Journal    
DOI: 10.1123/mcj.16.1.64     Document Type: Article

References (85)

1. Abbott, R.D., White, L.R., Ross, G.W., Masaki, K.H., Curb, J.D., & Petrovitch, H. (2004). Walking and dementia in physically capable elderly men. Journal of the American Medical Association, 292(12), 1447-1453. (Pubitemid 39258337)
2. Allan, L.M., Ballard, C.G., Burn, D.J., & Kenny, R.A. (2005). Prevalence and severity of gait disorders in Alzheimer's and non-Alzheimer's dementias. Journal of the American Geriatrics Society, 53(10), 1681-1687. (Pubitemid 43109930)
3. American Psychiatric Association. A. P. (2000). Diagnostic and Statistical Manual of Mental Disorders (text revision ed.). Washington, DC: Author.
4. Atkinson, H.H., Rosano, C., Simonsick, E.M., Williamson, J.D., Davis, C., Ambrosius, W.T., et al. (2007). Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62(8), 844-850. (Pubitemid 350131668)
5. Baddeley, A. (1992). Working memory. Science, 255(5044), 556-559.
6. Baddeley, A., & Logie, R. (1999). Working memory: The multiple-component model. In A. Miyake & P. Shah (Eds.), Models of working memory: Mechanisms of active maintenance and executive control (pp. 28-61). New York, NY: Cambridge University Press.
7. Benton, A.H. K. (1976). Multilingual aphasia examination. Iowa City: University of Iowa.
8. Bilney, B., Morris, M., & Webster, K. (2003). Concurrent related validity of the GAITRite walkway system for quantification of the spatial and temporal parameters of gait. Gait & Posture, 17(1), 68-74. (Pubitemid 36132191)
9. Ble, A., Volpato, S., Zuliani, G., Guralnik, J.M., Bandinelli, S., Lauretani, F., et al. (2005). Executive function correlates with walking speed in older persons: the InCHIANTI study. Journal of the American Geriatrics Society, 53(3), 410-415. (Pubitemid 41623518)
10. Blessed, G., Tomlinson, B.E., & Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. The British Journal of Psychiatry, 114(512), 797-811.
11. Brach J.S., Perera S, Studenski S, Newman A.B. (2008). The reliability and validity of measures of gait variability in community-dwelling older adults. Archives of Physical Medicine and Rehabilitation 89(12):2293-6
12. Brach, J.S., Studenski, S., Perera, S., VanSwearingen, J.M., & Newman, A.B. (2008). Stance time and step width variability have unique contributing impairments in older persons. Gait & Posture, 27(3), 431-439. (Pubitemid 351726213)
13. Camicioli, R., Howieson, D., Lehman, S., & Kaye, J. (1997). Talking while walking: the effect of a dual task in aging and Alzheimer's disease. Neurology, 48(4), 955-958.
14. Cesari, M., Kritchevsky, S.B., Penninx, B.W., Nicklas, B.J., Simonsick, E.M., Newman, A.B., et al. (2005). Prognostic value of usual gait speed in well-functioning older people-results from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 53(10), 1675-1680. (Pubitemid 43109929)
15. Chui, H.C., Victoroff, J.I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992). Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology, 42(3 Pt 1), 473-480.
16. Craik, F., & Byrd, M. (1982). Aging and cognitive deficits: the role of attentional resources. In F.I.M.C.S. Trehub (Ed.), Aging and Cognitive Processes (pp. 191-211). New York: Plenum.
17. Crystal, H.A., Dickson, D., Davies, P., Masur, D., Grober, E., & Lipton, R.B. (2000). The relative frequency of "dementia of unknown etiology" increases with age and is nearly 50% in nonagenarians. Archives of Neurology, 57(5), 713-719. (Pubitemid 30252807)
18. Drew, T., Prentice, S., & Schepens, B. (2004). Cortical and brainstem control of locomotion. Progress in Brain Research, 143, 251-261. (Pubitemid 37443000)
19. Fuld, P. (1978). Psychological testing in the differential diagnosis of the dementias In, T.R. Katzman R, Bick KL (Ed.), Alzheimer's disease: senile dementia and related disorders (Vol. 7, pp. 185-193). New York: Raven Press.
20. Goodglass, H.K. E. (1983). The assessment of aphasia and related disorders (2nd ed.). Philadelphia: Lea & Febiger.
21. Grober, E., Buschke, H., Crystal, H., Bang, S., & Dresner, R. (1988). Screening for dementia by memory testing. Neurology, 38(6), 900-903.
22. Grober, E., Dickson, D., Sliwinski, M.J., Buschke, H., Katz, M., Crystal, H., et al. (1999). Memory and mental status correlates of modified Braak staging. Neurobiology of Aging, 20(6), 573-579. (Pubitemid 30064402)
23. Hair, J.E., Jr. A. R. E., Tatham RL & Black WC. (1998). Multivariate data analysis (5th ed.). Upper Saddle River, NJ: Prentice Hall.
24. Hausdorff, J.M. (2005). Gait variability: methods, modeling and meaning. Journal of Neuroengineering and Rehabilitation, 2, 19.
25. Hausdorff, J.M. (2007). Gait dynamics, fractals and falls: finding meaning in the stride-to- stride fluctuations of human walking. Human Movement Science, 26(4), 555-589.
26. Hirvensalo, M., Rantanen, T., & Heikkinen, E. (2000). Mobility difficulties and physical activity as predictors of mortality and loss of independence in the community-living older population. Journal of the American Geriatrics Society, 48(5), 493-498. (Pubitemid 30263100)
27. Holtzer, R., Verghese, J., Wang, C., Hall, C.B., & Lipton, R.B. (2008). Within-person acrossneuropsychological test variability and incident dementia. Journal of the American Medical Association, 300(7), 823-830.
28. Holtzer, R., Burright, R.G., & Donovick, P.J. (2004). The sensitivity of dual-task performance to cognitive status in aging. Journal of the International Neuropsychological Society, 10(2), 230-238. (Pubitemid 38418180)
29. Holtzer, R., Friedman, R., Lipton, R.B., Katz, M., Xue, X., & Verghese, J. (2007). The relationship between specific cognitive functions and falls in aging. Neuropsychology, 21(5), 540-548. (Pubitemid 47488797)
30. Holtzer, R., Ozelius, L., Xue, X., Wang, T., Lipton, R.B., & Verghese, J. (2010). Differential effects of COMT on gait and executive control in aging. Neurobiology of Aging, 31(3), 523-531.
31. Holtzer, R., Stern, Y., & Rakitin, B.C. (2004). Age-related differences in executive control of working memory. Memory & Cognition, 32(8), 1333-1345. (Pubitemid 40524881)
32. Holtzer, R., Stern, Y., & Rakitin, B.C. (2005). Predicting Age-Related Dual-Task Effects With Individual Differences on Neuropsychological Tests. Neuropsychology, 19(1), 18-27. (Pubitemid 40144309)
33. Holtzer, R., Verghese, J., Xue, X., & Lipton, R.B. (2006). Cognitive Processes Related to Gait Velocity: Results From the Einstein Aging Study. Neuropsychology, 20(2), 215-223.
34. Inzitari, M., Baldereschi, M., Carlo, A.D., Bari, M.D., Marchionni, N., Scafato, E., et al. (2007). Impaired attention predicts motor performance decline in older community-dwellers with normal baseline mobility: results from the Italian Longitudinal Study on Aging (ILSA). The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62(8), 837-843. (Pubitemid 350131667)
35. Katzman, R., Aronson, M., Fuld, P., Kawas, C., Brown, T., Morgenstern, H., et al. (1989). Development of dementing illnesses in an 80-year-old volunteer cohort. Annals of Neurology, 25(4), 317-324. (Pubitemid 19104162)
36. Kerber, K.A., Enrietto, J.A., Jacobson, K.M., & Baloh, R.W. (1998). Disequilibrium in older people: a prospective study. Neurology, 51(2), 574-580. (Pubitemid 28406341)
37. Laird, N.M., & Ware, J.H. (1982). Random-effects models for longitudinal data. Biometrics, 38(4), 963-974.
38. Li, K.Z.H., Lindenberger, U., Freund, A.M., & Baltes, P.B. (2001). Walking while memorizing: Age-related differences in compensatory behavior. Psychological Science, 12(3), 230-237. (Pubitemid 33653536)
39. Lindenberger, U., Marsiske, M., & Baltes, P.B. (2000). Memorizing while walking: Increase in dual-task costs from young adulthood to old age. Psychology and Aging, 15(3), 417-436.
40. Lipton, R.B., Katz, M.J., Kuslansky, G., Sliwinski, M.J., Stewart, W.F., Verghese, J., et al. (2003). Screening for dementia by telephone using the memory impairment screen. Journal of the American Geriatrics Society, 51(10), 1382-1390. (Pubitemid 37259866)
41. Masur, D.M., Sliwinski, M., Lipton, R.B., Blau, A.D., & Crystal, H.A. (1994). Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology, 44(8), 1427-1432. (Pubitemid 24247431)
42. McDowd, J.M., & Shaw, R.J. (2000). Attention and aging: A functional perspective. In F.I.M. Craik & T.A. Salthouse (Eds.), The handbook of aging and cognition (2nd ed., pp. 221-292). Mahwah, NJ: Lawrence Erlbaum Associates Publishers.
43. McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939-944. (Pubitemid 14076461)
44. Miyake, A., Friedman, N.P., Emerson, M.J., Witzki, A.H., Howerter, A., & Wager, T.D. (2000). The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. Cognitive Psychology, 41(1), 49-100.
45. Montero-Odasso, M., Schapira, M., Soriano, E.R., Varela, M., Kaplan, R., Camera, L.A., et al. (2005). Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 60(10), 1304-1309. (Pubitemid 41612425)
46. Morris, M.E., Iansek, R., Matyas, T.A., & Summers, J.J. (1994). Ability to modulate walking cadence remains intact in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 57(12), 1532-1534.
47. Newman, A.B., Haggerty, C.L., Kritchevsky, S.B., Nevitt, M.C., & Simonsick, E.M. (2003). Walking performance and cardiovascular response: associations with age and morbidity-the Health, Aging and Body Composition Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 58(8), 715-720. (Pubitemid 36994946)
48. Newman, A.B., Simonsick, E.M., Naydeck, B.L., Boudreau, R.M., Kritchevsky, S.B., Nevitt, M.C., et al. (2006). Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. Journal of the American Medical Association, 295(17), 2018-2026. (Pubitemid 44794004)
49. Pashler, H. (1994). Dual-task interference in simple tasks: data and theory. Psychological Bulletin, 116(2), 220-244.
50. Pashler, H.E. (1998). The psychology of attention. The psychology of attention. xiv (494 pp.). Cambridge, MA: The MIT Press.
51. Posner, M.I., & Petersen, S.E. (1990). The attention system of the human brain. Annual Review of Neuroscience, 13, 25-42. (Pubitemid 20100639)
52. Reitan, R.M. (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271-276.
53. Rosano, C., Aizenstein, H.J., Studenski, S., & Newman, A.B. (2007). A Regions-of-Interest Volumetric Analysis of Mobility Limitations in Community-Dwelling Older Adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62(9), 1048-1055. (Pubitemid 47531224)
54. Rosano, C., Brach, J., Studenski, S., Longstreth, W.T., Jr., & Newman, A.B. (2007). Gait Variability Is Associated with Subclinical Brain Vascular Abnormalities in High- Functioning Older Adults. Neuroepidemiology, 29(3-4), 193-200. (Pubitemid 351197522)
55. Scherder, E., Eggermont, L., Swaab, D., van Heuvelen, M., Kamsma, Y., de Greef, M., et al. (2007). Gait in ageing and associated dementias; its relationship with cognition. Neuroscience and Biobehavioral Reviews, 31(4), 485-497. (Pubitemid 46527880)
56. Shkuratova, N., Morris, M.E., & Huxham, F. (2004). Effects of age on balance control during walking. Archives of Physical Medicine and Rehabilitation, 85(4), 582-588. (Pubitemid 38881046)
57. Simonsick, E.M., Montgomery, P.S., Newman, A.B., Bauer, D.C., & Harris, T. (2001). Measuring fitness in healthy older adults: the Health ABC Long Distance Corridor Walk. Journal of the American Geriatrics Society, 49(11), 1544-1548. (Pubitemid 33051409)
58. Sliwinski, M.J., Hofer, S.M., Hall, C., Buschke, H., & Lipton, R.B. (2003). Modeling Memory Decline in Older Adults: The Importance of Preclinical Dementia, Attrition, and Chronological Age. Psychology and Aging, 18(4), 658-671. (Pubitemid 37543429)
59. Sliwinski, M., Buschke, H., Stewart, W.F., Masur, D., & Lipton, R.B. (1997). The effect of dementia risk factors on comparative and diagnostic selective reminding norms. Journal of the International Neuropsychological Society, 3(4), 317-326. (Pubitemid 27351145)
60. Snijders, A.H., van de Warrenburg, B.P., Giladi, N., & Bloem, B.R. (2007). Neurological gait disorders in elderly people: clinical approach and classification. The Lancet Neurology, 6(1), 63-74. (Pubitemid 44895449)
61. Sparrow, W.A., Bradshaw, E.J., Lamoureux, E., & Tirosh, O. (2002). Ageing effects on the attention demands of walking. Human Movement Science, 21(5-6), 961-972. (Pubitemid 38351632)
62. Springer, S., Giladi, N., Peretz, C., Yogev, G., Simon, E.S., & Hausdorff, J.M. (2006). Dual-tasking effects on gait variability: the role of aging, falls, and executive function. Movement Disorders, 21(7), 950-957. (Pubitemid 44184595)
63. Starr, J.M., Leaper, S.A., Murray, A.D., Lemmon, H.A., Staff, R.T., Deary, I.J., et al. (2003). Brain white matter lesions detected by magnetic resonance [correction of resonance] imaging are associated with balance and gait speed. Journal of Neurology, Neurosurgery, and Psychiatry, 74(1), 94-98. (Pubitemid 36069043)
64. Stern, Y. (2002). What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society, 8(3), 448-460.
65. Stern, Y., Andrews, H., Pittman, J., Sano, M., Tatemichi, T., Lantigua, R., et al. (1992). Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education. Archives of Neurology, 49(5), 453-460.
66. Studenski, S., Perera, S., Wallace, D., Chandler, J.M., Duncan, P.W., Rooney, E., et al. (2003). Physical performance measures in the clinical setting. Journal of the American Geriatrics Society, 51(3), 314-322. (Pubitemid 36348892)
67. Stufflebeam, S.M., & Rosen, B.R. (2007). Mapping cognitive function. Neuroimaging Clinics of North America, 17(4), 469-484 viii-ix.
68. Sturm, W., Willmes, K., Orgass, B., & Hartje, W. (1997). Do specific attention deficits need specific training? Neuropsychological Rehabilitation, 7(2), 81-103. (Pubitemid 27234615)
69. Verghese, J., Crystal, H.A., Dickson, D.W., & Lipton, R.B. (1999). Validity of clinical criteria for the diagnosis of dementia with Lewy bodies. Neurology, 53(9), 1974-1982.
70. Verghese, J., Buschke, H., Viola, L., Katz, M., Hall, C., Kuslansky, G., et al. (2002). Validity of divided attention tasks in predicting falls in older individuals: a preliminary study. Journal of the American Geriatrics Society, 50(9), 1572-1576. (Pubitemid 35024652)
71. Verghese, J., Lipton, R.B., Hall, C.B., Kuslansky, G., Katz, M.J., & Buschke, H. (2002a). Abnormality of gait as a predictor of non-Alzheimer's dementia. The New England Journal of Medicine, 347(22), 1761-1768. (Pubitemid 35375615)
72. Verghese, J., Katz, M.J., Derby, C.A., Kuslansky, G., Hall, C.B., & Lipton, R.B. (2004). Reliability and validity of a telephone-based mobility assessment questionnaire. Age and Ageing, 33(6), 628-632. (Pubitemid 39504300)
73. Verghese, J., Kuslansky, G., Holtzer, R., Katz, M., Xue, X., Buschke, H., et al. (2007). Walking while talking: effect of task prioritization in the elderly. Archives of Physical Medicine and Rehabilitation, 88(1), 50-53. (Pubitemid 46026741)
74. Verghese, J., LeValley, A., Hall, C.B., Katz, M.J., Ambrose, A.F., & Lipton, R.B. (2006). Epidemiology of gait disorders in community-residing older adults. Journal of the American Geriatrics Society, 54(2), 255-261.
75. Verghese, J., Wang, C., Lipton, R.B., Holtzer, R., & Xue, X. (2007). Quantitative gait dysfunction and risk of cognitive decline and dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 78(9), 929-935. (Pubitemid 47310826)
76. Verghese, J., Holtzer, R., Lipton, R.B., & Wang, C. (2009). Quantitative Gait Markers and Incident Fall Risk in Older Adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64(8), 896-901.
77. Verghese, J., Mahoney, J., Ambrose, A.F., Wang, C., & Holtzer, R. (2010). Effect of Cognitive Remediation on Gait in Sedentary Seniors. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65(12), 1338-1343.
78. Verhaeghen, P., & Cerella, J. (2002). Aging, executive control, and attention: a review of meta-analyses. Neuroscience and Biobehavioral Reviews, 26(7), 849-857. (Pubitemid 35430288)
79. Verhaeghen, P., Steitz, D.W., Sliwinski, M.J., & Cerella, J. (2003). Aging and dual-task performance: a meta-analysis. Psychology and Aging, 18(3), 443-460. (Pubitemid 37152063)
80. Wechsler, D. (1981). Wechsler Adult Intelligence Scale-revised. New York: The Psychological Corporation.
81. West, R., Murphy, K.J., Armilio, M.L., Craik, F.I., & Stuss, D.T. (1992). Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control. Brain and Cognition, 49(3), 402-419.
82. Weuve, J., Kang, J.H., Manson, J.E., Breteler, M.M., Ware, J.H., & Grodstein, F. (2004). Physical activity, including walking, and cognitive function in older women. Journal of the American Medical Association, 292(12), 1454-1461. (Pubitemid 39258338)
83. Whitman, G.T., Tang, Y., Lin, A., & Baloh, R.W. (2001). A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology, 57(6), 990-994. (Pubitemid 32880191)
84. Willis, S.L., Tennstedt, S.L., Marsiske, M., Ball, K., Elias, J., Koepke, K.M., et al. (2006). Long-term effects of cognitive training on everyday functional outcomes in older adults. Journal of the American Medical Association, 296(23), 2805-2814. (Pubitemid 44969180)
85. Wolinsky, F.D., Unverzagt, F.W., Smith, D.M., Jones, R., Stoddard, A., & Tennstedt, S.L. (2006). The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 years. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 61(12), 1324-1329. (Pubitemid 46147791)