Association between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet's disease

Molecular Vision

Volumn 18, Issue , 2012, Pages 1696-1700

  Karakus, Nevin ^a,b   Yigit, Serbulent ^b   Kalkan, Goknur ^c   Rustemoglu, Aydin ^b   Inanir, Ahmet ^c   Gul, Ulker ^d   Pancar, Gunseli Sefika ^e   Akkanet, Songul ^b   Ates, Omer ^b  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b GAZIOSMANPASA UNIVERSITY   (Turkey)

^c Department of Physical Therapy and Rehabilitation ^*  (Turkey)

^d ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^e Tokat State Hospital   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); COLCHICINE;

ADULT; ARTICLE; BEHCET DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG RESPONSE; FEMALE; GENE; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; PRIORITY JOURNAL;

ADULT; ALLELES; BEHCET SYNDROME; CASE-CONTROL STUDIES; COHORT STUDIES; COLCHICINE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GOUT SUPPRESSANTS; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RISK FACTORS; TREATMENT FAILURE;

EID: 84863331663     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. N Engl J Med 1999; 341:1284-91. [PMID: 10528040]
2. Kuzu MA, Ozaslan C, Koksoy C, Gurler A, Tuzuner A. Vascular involvement in Behcet's disease: 8 year audit. World J Surg 1994; 18:948-53. [PMID: 7846925]
3. Gül A, Ozbek U, Ozturk C, Inanc M, Konice M, Ozcelik T. Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease. Br J Rheumatol 1996; 35:1178-80. [PMID: 8948311]
4. Saadoun D, Wechsler B. Behcet's disease. Orphanet J Rare Dis 2012; 7:20. [PMID: 22497990]
5. Pineton de Chambrun MP, Wechsler B, Geri G, Cacoub P, Saadoun D. New insights into the pathogenesis of Behcet's disease. Autoimmun Rev. 2011 [PMID: 22197900]
6. Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M. Close association of HLA-Bw51 with Behcet's disease. Arch Ophthalmol 1982; 100:1455-8. [PMID: 6956266]
7. Toffoli G, Russo A, Innocenti F, Corona G, Tumolo S, Sartor F, Mini E, Boiocchi M. Effect of methylenetetrahydrofolate reductase 677CRT polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. Int J Cancer 2003; 103:294-9. [PMID: 12471611]
8. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111-3. [PMID: 7647779]
9. Kang SS, Zhou J, Wong PW, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 1988; 43:414-21. [PMID: 3177384]
10. Rosendaal FR. Risk factors for venous thrombosis: prevalence, risk, and interaction. Semin Hematol 1997; 34:171-7. [PMID: 9241704]
11. Seshadri N, Robinson K. Homocysteine, B vitamins and coronary artery disease. Med Clin North Am 2000; 84:215-7. [PMID: 10685136]
12. Margaglione M, D'Andrea G, d'Addedda M, Giuliani N, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Brancaccio V, Di Minno G. The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation. Thromb Haemost 1998; 79:907-11. [PMID: 9609218]
13. Gemmati D, Serino ML, Trivellato C, Fiorini S, Scapoli GL. C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients. Haematologica 1999; 84:824-8. [PMID: 10477457]
14. Aksu K, Turgan N, Oksel F, Keser G, Ozmen D, Kitapçioǧlu G, Gümüşdiş G, Bayindir O, Doǧanavşargil E. Hyperhomocysteinaemia in Behcet's disease. Rheumatology 2001; 40:687-90. [PMID: 11426028]
15. Okka M, Ozturk M, Kockar MC, Bavbek N, Rasier Y, Gunduz K. Plasma homocysteine level and uveitis in Behç et's disease. Isr Med Assoc J 2002; 4:931-4. [PMID: 12455183]
16. Er H, Evereklioglu C, Cumurcu T, Türköz Y, Ozerol E, Sahin K, Doganay S. Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease. Br J Ophthalmol 2002; 86:653-7. [PMID: 12034688]
17. Korkmaz C, Bozan B, Kosar M, Sahin F, Gülbas Z. Is there an association of plasma homocysteine levels with vascular involvement in patients with Behcet's syndrome? Clin Exp Rheumatol 2002; 20:S30-4. [PMID: 12371632]
18. Lee YJ, Kang SW, Yang JI, Choi YM, Sheen D, Lee EB, Choi SW, Song YW. Coagulation parameters and plasma total homocysteine levels in Behcet's disease. Thromb Res 2002; 106:19-24. [PMID: 12165284]
19. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990; 335:1078-80. [PMID: 1970380]
20. Canataroglu A, Tanriverdi K, Inal T, Seydaoglu G, Arslan D, Ozbek S, Baslamisli F. Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease. Rheumatol Int 2003; 23:236-40. [PMID: 14504916]
21. Ozkul Y, Evereklioglu C, Borlu M, Taheri S, Calis M, Dündar M, Ilhan O. 5,10-Methylenetetrahydrofolate reductase C677T gene polymorphism in Behcet's patients with or without ocular involvement. Br J Ophthalmol 2005; 89:1634-7. [PMID: 16299146]
22. Espinosa G, Font J, Tassies D, Vidaller A, Deulofeu R, López-Soto A, Cervera R, Ordinas A, Ingelmo M, Reverter JC. Vascular involvement in Behcet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 2002; 112:37-43. [PMID: 11812405]
23. Ricart JM, Vayá A, Todolí J, Calvo J, Villa P, Estellés A, España F, Santaolaria M, Corella D, Aznar J. Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events. Thromb Haemost 2006; 95:618-24. [PMID: 16601831]
24. Koubaa N, Hammami S, Nakbi A, Ben Hamda K, Mahjoub S, Kosaka T, Hammami M. Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behçet's disease patients. Clin Chem Lab Med 2008; 46:187-92. [PMID: 18076365]
25. Toydemir PB, Elhan AH, Tukun A, Toydemir R, Gurler A, Tuzuner A, Bokesoy I. Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothombin gene G20210A mutations on deep venous thrombogenesis in Behçet's disease. J Rheumatol 2000; 27:2849-54. [PMID: 11128675]
26. Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH, Livneh A, Rosenberg N, Gelernter I, Gur H, Ehrenfeld M. Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease. Ann Rheum Dis 2004; 63:1445-9. [PMID: 15479893]
27. Caramaschi P, Poli G, Bonora A, Volpe A, Tinazzi I, Pieropan S, Bambara LM, Biasi D. A study on thrombophilic factors in Italian Behcet's patients. Joint Bone Spine 2010; 77:330-4. [PMID: 20452800]
28. Dagan E, Baruch Y, Fiorilli M, Rozenbaum M, Rosner I, Gershoni-Baruch R. Vascular behcet and mutations in thrombogenic genes: methylene tetrahydrofolate reductase, factor v, and prothrombin. Genet Test Mol Biomarkers 2012; 16:30-5. [PMID: 21861708]
29. Vayá A, Miguel De la Fuente J, Suescun M, España E, Ricart JM. Posterior ocular involvement in Beçet's disease and thrombophilic mutations. Clin Hemorheol Microcirc. 2012 [PMID: 22495315]
30. Ehrenfeld M, Levy M, Bar EM, Gallily R, Eliakim M. Effect of colchicine on polymorphonuclear leucocyte chemotaxis in human volunteers. Br J Clin Pharmacol 1980; 10:297-300. [PMID: 7437248]
31. Ozen F, Silan C, Uludag A, Candan F, Silan F, Ozdemir S, Atik S, Ozdemir O. Association between ABCB1 (MDR1) gene 3435 C>T polymorphism and colchicine unresponsiveness of FMF patients. Ren Fail 2011; 33:899-903. [PMID: 21851199]
32. Soylemezoglu O, Arga M, Fidan K, Gonen S, Emeksiz HC, Hasanoglu E, Buyan N. Unresponsiveness to colchicine therapy in patients with familial Mediterranean fever homozygous for the M694V mutation. J Rheumatol 2010; 37:182-9. [PMID: 20008920]
33. Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H. A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 2001; 44:2686-92. [PMID: 11710724]
34. Husemoen LL, Toft U, Fenger M, Jorgensen T, Johansen N, Linneberg A. The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy? Int J Epidemiol 2006; 35:954-61. [PMID: 16766537]