A study on thrombophilic factors in Italian Behcet's patients

Joint Bone Spine

Volumn 77, Issue 4, 2010, Pages 330-334

  Caramaschi, Paola ^a   Poli, Giovanni ^b   Bonora, Adriana ^b   Volpe, Alessandro ^c   Tinazzi, Ilaria ^a   Pieropan, Sara ^a   Bambara, Lisa M ^a   Biasi, Domenico ^a  

^a Dipartimento di Medicina Clinica e Sperimentale   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c Ospedale di Negrar   (Italy)

Author keywords

Behcet's Disease; Thrombophilic Factors; Thrombosis; Vasculo Behcet

Indexed keywords

APC PROTEIN; BLOOD CLOTTING FACTOR 5; FOLIC ACID; HOMOCYSTEINE; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTEIN S; ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; LIPOPROTEIN A RECEPTOR; LIPOPROTEIN RECEPTOR; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PROTHROMBIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTERY THROMBOSIS; ARTICLE; BEHCET DISEASE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLIC ACID BLOOD LEVEL; GENE MUTATION; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; SUPERFICIAL THROMBOPHLEBITIS; VEIN THROMBOSIS; BLOOD; CASE CONTROL STUDY; COMPLICATION; ETHNOLOGY; GENETIC POLYMORPHISM; GENETICS; ITALY; METABOLISM; RISK FACTOR; THROMBOSIS;

ADULT; ANTIBODIES, ANTIPHOSPHOLIPID; ANTITHROMBINS; BEHCET SYNDROME; CASE-CONTROL STUDIES; FACTOR V; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; ITALY; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PROTEIN C; PROTHROMBIN; RECEPTORS, LIPOPROTEIN; RISK FACTORS; THROMBOSIS;

EID: 77954570210     PISSN: 1297319X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbspin.2010.02.022     Document Type: Article

References (36)

1. Ko G.Y., Byun J.Y., Choi B.G., et al. The vascular manifestations of Behcet's disease: angiographic and CT findings. Br J Radiol 2000, 73:1270-1274.
2. Gurler A., Boyvat A., Tursen U. Clinical manifestations of Behcet's disease: an analysis of 2147 patients. Yonsei Med J 1997, 38:423-427.
3. Koc Y., Gullu I., Akpek G., et al. Vascular involvement in Behcet's disease. J Rheumatol 1992, 19:402-410.
4. Sengul N., Demirer S., Yerdel M.A., et al. Comparison of coagulation parameters for healthy subjects and Behcet disease patients with and without vascular involvement. World J Surg 2000, 24:1584-1588.
5. Gul A., Inanc M., Ocal L., et al. Familial aggregation of Behcet's disease in Turkey. Ann Rheum Dis 2000, 59:622-625.
6. Kone-Paut I., Geisler I., Wechsler B., et al. Familial aggregation in Behcet's disease: high frequency in siblings and parents of pediatric probands. J Pediatr 1999, 135:89-93.
7. Yabuki K., Mizuki N., Ota M., et al. Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece. Invest Ophthalmol Vis Sci 1999, 40:1921-1926.
8. Kera J., Mizuki N., Ota M., et al. Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Behcet's disease in Italian patients. Tissue Antigens 1999, 54:565-571.
9. Salvarani C., Boiardi L., Mantovani V., et al. Association of MICA alleles and HLA-B51 in Italian patients with Behcet's disease. J Rheumatol 2001, 28:1867-1870.
10. Gul A., Ozbek U., Ozturk C., et al. Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease. Br J Rheumatol 1996, 35:1178-1180.
11. Toydemir P.B., Elhan A.H., Tukun A., et al. Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothombin gene G20210A mutations on deep venous thrombogenesis in Behcet's disease. J Rheumatol 2000, 27:2849-2854.
12. Mammo L., Al-Dalaan A., Bahabri S.S., et al. Association of factor V Leiden with Behcet's disease. J Rheumatol 1997, 24:2196-2198.
13. Verity D.H., Vaughan R.W., Madanat W., et al. Factor V Leiden mutation is associated with ocular involvement in Behcet disease. Am J Ophthalmol 1999, 128:352-356.
14. Oner A.F., Gurgey A., Gurler A., et al. Factor V Leiden mutation in patients with Behcet's disease. J Rheumatol 1998, 25:496-498.
15. Gurgey A., Balta G., Boyvat A. Factor V Leiden mutation and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease. Blood Coagul Fibrinolysis 2003, 14:121-124.
16. Batioglu F., Atmaca L.S., Karabulut H.G., et al. Factor V Leiden and prothrombin gene G20210A mutations in ocular Behcet disease. Acta Ophthalmol Scand 2003, 81:283-285.
17. Mader R., Ziv M., Adawi M., et al. Thrombophilic factors and their relation to thromboembolic and other clinical manifestations in Behçet's disease. J Rheumatol 1999, 26:2404-2408.
18. Lee Y.J., Kang S.W., Yang J.I., et al. Coagulation parameters and plasma total homocysteine levels in Behcet's disease. Thromb Res 2002, 106:19-24.
19. Espinosa G., Font J., Tassies D., et al. Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 2002, 112:75-76.
20. Leiba M., Seligsohn U., Sidi Y., et al. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease. Ann Rheum Dis 2004, 63:1445-1449.
21. Ricart J.M., Vaya A., Todoli J., et al. Thrombophilic risk factors and homocysteine levels in Behcet's disease in eastern Spain and their association with thrombotic events. Thromb Haemost 2006, 95:618-624.
22. Okka M., Ozturk M., Kockar M.C., et al. Plasma homocysteine level and uveitis in Behçet's disease. Isr Med Assoc J 2002, 4(Suppl. 11):931-934.
23. Er H., Evereklioglu C., Cumurcu T., et al. Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behçet's disease. Br J Ophthalmol 2002, 86:653-657.
24. Aksu K., Turgan N., Oksel F., et al. Hyperhomocysteinaemia in Behçet's disease. Rheumatology 2001, 40:687-690.
25. Korkmaz C., Bozan B., Kosar M., et al. Is there an association of plasma homocysteine levels with vascular involvement in patients with Behçet's syndrome?. Clin Exp Rheumatol 2002, 20(Suppl. 26):S30-S34.
26. Canataroglu A., Tanriverdi K., Inal T., et al. Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease. Rheumatol Int 2003, 23:236-240.
27. al-Dalaan A.N., al-Ballaa S.R., al-Janadi M.A., et al. Association of anti-cardiolipin antibodies with vascular thrombosis and neurological manifestation of Behçets disease. Clin Rheumatol 1993, 12:28-30.
28. Gürbüz O., Ozdemir Y., Coşar C.B., et al. Lipoprotein(a) in Behçet's disease as an indicator of disease activity and in thrombotic complications. Eur J Ophthalmol 2001, 11:62-65.
29. Criteria for diagnosis of Behcet's disease. Lancet 1990, 335:1078-1080. International Study Group for Behcet's disease.
30. Sarica-Kucukoglu R., Akdag-Kose A., Kayabali M., et al. Vascular involvement in Behcet's disease: a retrospective analysis of 2319 cases. Int J Dermatol 2006, 45:919-921.
31. Chafa O., Fischer A.M., Meriane F., et al. Behçet syndrome associated with protein S deficiency. Thromb Haemost 1992, 67:1-3.
32. Bayraktar Y., Soylu A.R., Balkanci F., et al. Arterial thrombosis leading to intestinal infarction in a patient with Behçet's disease associated with protein C deficiency. Am J Gastroenterol 1998, 93:2556-2558.
33. Calamia K.T., Schirmer M., Melikoglu M. Major vessel involvement in Behçet's disease. Curr Opin Rheumatol 2005, 17:1-8.
34. Ahn J.K., Lee Y.S., Jeon C.H., et al. Treatment of venous thrombosis associated with Behçet's disease: immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulation. Clin Rheumatol 2008, 27:201-205.
35. Silingardi M., Salvarani C., Boiardi L., et al. Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behcet's disease and deep vein thrombosis. Arthritis Rheum Res 2004, 51:177-183.
36. Ricart J.M., Vaya A., Todoli J., et al. Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events. Thromb Haemost 2006, 95:618-624.