Protein kinase C-α comes to the rescue of aquaporin-2

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 1, 2012, Pages

  Bagnasco, Serena M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; AQUAPORIN 2; ARGIPRESSIN; CALCINEURIN; CARRIER PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN KINASE C ALPHA; SERINE; SODIUM; UNCLASSIFIED DRUG; UREA; UREA TRANSPORTER A1; UREA TRANSPORTER A3; WATER;

APICAL MEMBRANE; BIOINFORMATICS; DEPHOSPHORYLATION; DOWN REGULATION; EDITORIAL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLUID BALANCE; GENETIC TRANSCRIPTION; HYPEROSMOLARITY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INTERSTITIUM; KIDNEY MEDULLA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; URINARY EXCRETION; WATER RETENTION; WATER TRANSPORT;

EID: 84863330500     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00225.2012     Document Type: Editorial

References (13)

1. Blount MA, Mistry AC, Fröhlich O, Price SR, Chen G, Sands JM, Klein JD. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation. Am J Physiol Renal Physiol 295: F295-F299, 2008.
2. Gillin AG, Sands JM. Characteristics of osmolarity-stimulated urea transport in the rat IMCD. Am J Physiol Renal Fluid Electrolyte Physiol 262: F1061-F1067, 1992.
3. Hwang S, Gunaratne R, Rinschen MM, Yu MJ, Pisitkun T, Hoffert JD, Fenton RA, Knepper MA, Chou CL. Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters. Am J Physiol Renal Physiol 299: F559-F567, 2010.
4. Ilori TO, Wang Y, Blount MA, Martin CF, Sands JM, Klein JD. Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. Am J Physiol Renal Physiol 302: F998-F1004, 2012.
5. Kato A, Klein JD, Zhang C, Sands JM. Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs. Am J Physiol Renal Physiol 279: F835-F840, 2000.
6. Klein JD, Martin CF, Kent KJ, Sands JM. Protein kinase C-_ mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct. Am J Physiol Renal Physiol 302: F1098-F1103, 2012.
7. Kortenoeven ML, Trimpert C, Brand MV, Li Y, Wetzels JF, Deen PM. In mpkCCD cells, long-term regulation of aquaporin-2 by vasopressin occurs independent of protein kinase A and CREB, but may involve Epac. Am J Physiol Renal Physiol 302: F1098-F1103, 2012.
8. Li C, Wang W, Rivard CJ, Lanaspa MA, Summer S, Schrier RW. Molecular mechanisms of angiotensin II stimulation on aquaporin-2 expression and trafficking. Am J Physiol Renal Physiol 300: F1255-F1261, 2011.
9. Moeller HB, Olesen ET, Fenton RA. Regulation of the water channel aquaporin-2 by posttranslational modification. Am J Physiol Renal Physiol 300: F1062-F1073, 2011.
10. Nakayama Y, Naruse M, Karakashian A, Peng T, Sands JM, Bagnasco SM. Cloning of the rat Slc14a2 gene and genomic organization of the UT-A urea transporter. Biochim Biophys Acta 1518: 19-26, 2001.
11. Nakayama Y, Peng T, Sands JM, Bagnasco S. The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression. J Biol Chem 275: 38275-38280, 2000.
12. Thai TL, Blount MA, Klein JD, Sands JM. Lack of protein kinase C-_ leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension. Am J Physiol Renal Physiol; doi: 10.1152/ajprenal.00098.2012.
13. Wang Y, Klein JD, Blount MA, Martin CF, Kent KJ, Pech V, Wall SM, Sands JM. Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts. J Am Soc Nephrol 20: 2018-2024, 2009.