Whose side are you on: Does serotonin preferentially activate the right hemisphere and norepinephrine the left?

Medical Hypotheses

Volumn 79, Issue 2, 2012, Pages 250-254

  Fitzgerald, Paul J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; NORADRENALIN; SEROTONIN; SEROTONIN RECEPTOR;

ARTICLE; BRAIN REGION; DICHOTIC LISTENING; ELECTROENCEPHALOGRAM; EVOKED RESPONSE; HEMISPHERIC DOMINANCE; HORMONE RECEPTOR INTERACTION; HUMAN; HYPOTHESIS; LEFT HEMISPHERE; MONOAMINERGIC SYSTEM; NERVE STIMULATION; NEUROIMAGING; NEUROPHYSIOLOGY; NEUROPSYCHIATRY; NONHUMAN; RIGHT HEMISPHERE;

ADRENERGIC NEURONS; BRAIN; FUNCTIONAL LATERALITY; HUMANS; MODELS, NEUROLOGICAL; NOREPINEPHRINE; SEROTONERGIC NEURONS; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 84863327450     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.05.001     Document Type: Article

References (54)

1. Reader T.A. Distribution of catecholamines and serotonin in the rat cerebral cortex: absolute levels and relative proportions. J Neural Transm 1981, 50:13-27.
2. Brown R.M., Crane A.M., Goldman P.S. Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates. Brain Res 1979, 168:133-150.
3. Glick S.D., Ross D.A., Hough L.B. Lateral asymmetry of neurotransmitters in human brain. Brain Res 1982, 234:53-63.
4. Guarneri P., Guarneri R., La Bella V., Scondotto S., Scoppa F., Piccoli F. Lateral differences in GABA binding sites in rat brain. Neurochem Res 1988, 13:209-211.
5. Silva M.A., Topic B., Lamounier-Zepter V., Huston J.P., Tomaz C., Barros M. Evidence for hemispheric specialization in the marmoset (Callithrix penicillata) based on lateralization of behavioral/neurochemical correlations. Brain Res Bull 2007, 74:416-428.
6. Mohr C., Landis T., Bracha H.S., Brugger P. Opposite turning behavior in right-handers and non-right-handers suggests a link between handedness and cerebral dopamine asymmetries. Behav Neurosci 2003, 117:1448-1452.
7. Martinez V., Sarter M. Lateralized attentional functions of cortical cholinergic inputs. Behav Neurosci 2004, 118:984-991.
8. Lapierre J.L., Kosenko P.O., Lyamin O.I., Kodama T., Mukhametov L.M., Siegel J.M. Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in northern fur seals. J Neurosci 2007, 27:11999-12006.
9. de Courten-Myers G.M. The human cerebral cortex: gender differences in structure and function. J Neuropathol Exp Neurol 1999, 58:217-226.
10. Draca S. Gender-specific functional cerebral asymmetries and unilateral cerebral lesion sequelae. Rev Neurosci 2010, 21:421-425.
11. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 1997, 94:5308-5313.
12. Liu Y., Jiang Y., Si Y., Kim J.Y., Chen Z.F., Rao Y. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature 2011, 472:95-99.
13. Bechtholt A.J., Hill T.E., Lucki I. Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test. Psychopharmacology (Berl) 2007, 190:531-540.
14. Brennan A.R., Arnsten A.F. Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Ann NY Acad Sci 2008, 1129:236-245.
15. Oke A., Keller R., Mefford I., Adams R.N. Lateralization of norepinephrine in human thalamus. Science 1978, 200:1411-1413.
16. Dluzen D.E., Kreutzberg J.D. Norepinephrine is lateralized within the olfactory bulbs of male mice. J Neurochem 1996, 66:1222-1226.
17. Kruglikov R.I., Orlova N.V., Getsova V.M. Content of norepinephrine and serotonin in symmetrical divisions of the brain of rats in the norm during learning and with the administration of peptides. Neurosci Behav Physiol 1992, 22:128-131.
18. Kabani N.J., Reader T.A., Dykes R.W. Monoamines and their metabolites in somatosensory, visual, and cingulate cortices of adult rat: differences in content and lack of sidedness. Neurochem Res 1990, 15:1031-1036.
19. Staiti A.M., Morgane P.J., Galler J.R., Grivetti J.Y., Bass D.C., Mokler D.J. A microdialysis study of the medial prefrontal cortex of adolescent and adult rats. Neuropharmacology 2011, 61:544-549.
20. Arato M., Frecska E., Tekes K., MacCrimmon D.J. Serotonergic interhemispheric asymmetry: gender difference in the orbital cortex. Acta Psychiatr Scand 1991, 84:110-111.
21. Demeter E., Tekes K., Majorossy K., Arato M., Somogyi E. Does 3H-imipramine binding asymmetry indicate psychiatric illness?. Acta Psychiatr Scand 1988, 77:746-747.
22. Demeter E., Tekes K., Majorossy K., Palkovits M., Soos M., Magyar K., et al. The asymmetry of 3H-imipramine binding may predict psychiatric illness. Life Sci 1989, 44:1403-1410.
23. Arora R.C., Meltzer H.Y. Laterality and 3H-imipramine binding: studies in the frontal cortex of normal controls and suicide victims. Biol Psychiatry 1991, 29:1016-1022.
24. Plenge P., Mellerup E.T., Laursen H. Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine. Prog Neuropsychopharmacol Biol Psychiatry 1990, 14:61-72.
25. Fink M., Wadsak W., Savli M., Stein P., Moser U., Hahn A., et al. Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET. Neuroimage 2009, 45:598-605.
26. Joyce J.N., Lexow N., Kim S.J., Artymyshyn R., Senzon S., Lawrence D., et al. Distribution of beta-adrenergic receptor subtypes in human post-mortem brain: alterations in limbic regions of schizophrenics. Synapse 1992, 10:228-246.
27. Brody A.L., Saxena S., Schwartz J.M., Stoessel P.W., Maidment K., Phelps M.E., et al. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res 1998, 84:1-6.
28. Hurwitz T.A., Clark C., Murphy E., Klonoff H., Martin W.R., Pate B.D. Regional cerebral glucose metabolism in major depressive disorder. Can J Psychiatry 1990, 35:684-688.
29. Smith G.S., Kramer E., Hermann C.R., Goldberg S., Ma Y., Dhawan, et al. Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression. Am J Geriatr Psychiatry 2002, 10:715-723.
30. Smith G.S., Kramer E., Hermann C., Ma Y., Dhawan V., Chaly T., et al. Serotonin modulation of cerebral glucose metabolism in depressed older adults. Biol Psychiatry 2009, 66:259-266.
31. Hoehn-Saric R., Schlund M.W., Wong S.H. Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder. Psychiatry Res 2004, 131:11-21.
32. Grefkes C., Wang L.E., Eickhoff S.B., Fink G.R. Noradrenergic modulation of cortical networks engaged in visuomotor processing. Cereb Cortex 2010, 20:783-797.
33. Passero S., Nardini M., Battistini N. Regional cerebral blood flow changes following chronic administration of antidepressant drugs. Prog Neuropsychopharmacol Biol Psychiatry 1995, 19:627-636.
34. Bruder G.E., Otto M.W., McGrath P.J., Stewart J.W., Fava M., Rosenbaum J.F., et al. Dichotic listening before and after fluoxetine treatment for major depression: relations of laterality to therapeutic response. Neuropsychopharmacology 1996, 15:171-179.
35. Bruder G.E., Stewart J.W., McGrath P.J., Deliyannides D., Quitkin F.M. Dichotic listening tests of functional brain asymmetry predict response to fluoxetine in depressed women and men. Neuropsychopharmacology 2004, 29:1752-1761.
36. Stewart J.W., Quitkin F.M., McGrath P.J., Bruder G.E. Do tricyclic responders have different brain laterality?. J Abnorm Psychol 1999, 108:707-710.
37. Coppen A. The biochemistry of affective disorders. Br J Psychiatry 1967, 113:1237-1264.
38. de Groot M.H., Nolen W.A., Huijsman A.M., Bouvy P.F. Lateralized neuropsychological functioning in depressive patients before and after drug therapy. Biol Psychiatry 1996, 40:1282-1287.
39. Carpenter L.L., Anderson G.M., Pelton G.H., Gudin J.A., Kirwin P.D., Price L.H., et al. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 1998, 19:26-35.
40. Dierks T., Barta S., Demisch L., Schmeck K., Englert E., Kewitz A., et al. Intensity dependence of auditory evoked potentials (AEPs) as biological marker for cerebral serotonin levels: effects of tryptophan depletion in healthy subjects. Psychopharmacology (Berl) 1999, 146:101-107.
41. Bruder G.E., Sedoruk J.P., Stewart J.W., McGrath P.J., Quitkin F.M., Tenke C.E. Electroencephalographic alpha measures predict therapeutic response to a selective serotonin reuptake inhibitor antidepressant: pre- and post-treatment findings. Biol Psychiatry 2008, 63:1171-1177.
42. Bruder G.E., Stewart J.W., Tenke C.E., McGrath P.J., Leite P., Bhattacharya N., et al. Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant. Biol Psychiatry 2001, 49:416-425.
43. Saletu B., Anderer P., Saletu-Zyhlarz G.M. EEG topography and tomography (LORETA) in diagnosis and pharmacotherapy of depression. Clin EEG Neurosci 2010, 41:203-210.
44. Arato M., Frecska E., Maccrimmon D.J., Guscott R., Saxena B., Tekes K., et al. Serotonergic interhemispheric asymmetry: neurochemical and pharmaco-EEG evidence. Prog Neuropsychopharmacol Biol Psychiatry 1991, 15:759-764.
45. Juckel G., Hegerl U., Giegling I., Mavrogiorgou P., Wutzler A., Schuhmacher C., et al. Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers. Am J Med Genet B: Neuropsychiatr Genet 2008, 147B:454-458.
46. Andersen S.L., Teicher M.H. Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats. Neuroreport 1999, 10:3497-3500.
47. Holmes A., Murphy D.L., Crawley J.N. Abnormal behavioral phenotypes of serotonin transporter knockout mice. parallels with human anxiety and depression. Biol Psychiatry 2003, 54:953-959.
48. Robert G., Drapier D., Bentue-Ferrer D., Renault A., Reymann J.M. Acute and chronic anxiogenic-like response to fluoxetine in rats in the elevated plus-maze: modulation by stressful handling. Behav Brain Res 2011, 220:344-348.
49. Walsh A., McDowall J., Grimshaw G.M. Hemispheric specialization for emotional word processing is a function of SSRI responsiveness. Brain Cogn 2010, 74:332-340.
50. Fitzgerald P.J. A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?. Psychopharmacology (Berl) 2011, 213:171-182.
51. Goldman-Rakic P.S., Brown R.M. Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Brain Res 1982, 256:339-349.
52. Comings D.E., Gade-Andavolu R., Gonzalez N., Wu S., Muhleman D., Blake H., et al. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clin Genet 2000, 58:375-385.
53. Kim C.H., Waldman I.D., Blakely R.D., Kim K.S. Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder. Ann NY Acad Sci 2008, 1129:256-260.
54. Piggott L.R. Overview of selected basic research in autism. J Autism Dev Disord 1979, 9:199-218.