Mycophenolate and lower graft function reduce the seroresponse of kidney transplant recipients to pandemic H1N1 vaccination

Kidney International

Volumn 82, Issue 2, 2012, Pages 212-219

  Mulley, William R ^a,b   Visvanathan, Kumar ^a,b   Hurt, Aeron C ^c   Brown, Fiona G ^a,b   Polkinghorne, Kevan R ^a,b   Mastorakos, Tasoula ^c   Lewicki, Michelle C ^a   Stuart, Rhonda L ^a,b   Tan, Sven Jean ^a   Chean, Roy ^a   Kerr, Peter G ^a,b   Kanellis, John ^a,b  

^a MONASH MEDICAL CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c WHO COLLABORATING CENTRE FOR REFERENCE AND RESEARCH ON INFLUENZA   (Australia)

Author keywords

efficacy; eGFR; hemodialysis; serology; swine flu; vaccine

Indexed keywords

INFLUENZA VACCINE; MYCOPHENOLIC ACID; VIRUS ANTIBODY;

2009 H1N1 INFLUENZA; ADULT; ANTIBODY TITER; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HEMODIALYSIS PATIENT; HUMAN; INFECTION PREVENTION; INFLUENZA VACCINATION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RENAL GRAFT DYSFUNCTION; SEASONAL INFLUENZA; SINGLE DRUG DOSE;

EID: 84863313839     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.106     Document Type: Article

References (24)

1. World Health Organisation. World Now at the Start of 2009 Influenza Pandemic 2009; http://www.who.int/mediacentre/news/statements/2009/h1n1- pandemic-phase6-20090611/en/index.html (accessed 13 April 2011).
2. Garten RJ, Davis CT, Russell CA et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 2009; 325: 197-201.
3. Hancock K, Veguilla V, Lu X et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med 2009; 361: 1945-1952.
4. McVernon J, Laurie K, Nolan T et al. Seroprevalence of 2009 pandemic influenza A(H1N1) virus in Australian blood donors, October-December. Euro Surv 2010; 15(40): pii¼19678.
5. Miller E, Hoschler K, Hardelid P et al. Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet 2010; 375: 1100-1108.
6. Greenberg ME, Lai MH, Hartel GF et al. Response to a monovalent 2009 influenza A (H1N1) vaccine. N Engl J Med 2009; 361: 2405-2413.
7. Clark TW, Pareek M, Hoschler K et al. Trial of 2009 influenza A (H1N1) monovalent MF59-adjuvanted vaccine. N Engl J Med 2009; 361: 2424-2435.
8. Zhu FC, Wang H, Fang HH et al. A novel influenza A (H1N1) vaccine in various age groups. N Engl J Med 2009; 361: 2414-2423.
9. Kumar D, Morris MI, Kotton CN et al. Guidance on novel influenza A/H1N1 in solid organ transplant recipients. Am J Transplant 2010; 10: 18-25.
10. Birdwell KA, Ikizler MR, Sannella EC et al. Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study. Am J Kidney Dis 2009; 54: 112-121.
11. Keshtkar-Jahromi M, Argani H, Rahnavardi M et al. Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: a controlled trial. Am J Nephrol 2008; 28: 654-660.
12. Sanchez-Fructuoso AI, Prats D, Naranjo P et al. Influenza virus immunization effectivity in kidney transplant patients subjected to two different triple-drug therapy immunosuppression protocols: mycophenolate vs. azathioprine. Transplantation 2000; 69: 436-439.
13. Scharpe J, Evenepoel P, Maes B et al. Influenza vaccination is efficacious and safe in renal transplant recipients. Am J Transplant 2008; 8: 332-337.
14. Smith KG, Isbel NM, Catton MG et al. Suppression of the humoral immune response by mycophenolate mofetil. Nephrol Dial Transplant 1998; 13: 160-164.
15. Salles MJ, Sens YA, Boas LS et al. Influenza virus vaccination in kidney transplant recipients: serum antibody response to different immunosuppressive drugs. Clin Transplant 2009; 24: E17-E23.
16. Danzinger-Isakov L, Kumar D. Guidelines for vaccination of solid organ transplant candidates and recipients. Am J Transplant 2009; 9(Suppl 4): S258-S262.
17. Brakemeier S, Schweiger B, Lachmann N et al. Immune response to an adjuvanted influenza A H1N1 vaccine (Pandemrix(R)) in renal transplant recipients. Nephrol Dial Transplant 2012; 1: 423-428.
18. Broeders NE, Hombrouck A, Lemy A et al. Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study. Clin J Am Soc Nephrol 2011; 6: 2573-2578.
19. Crespo M, Collado S, Mir M et al. Efficacy of influenza A H1N1/2009 vaccine in hemodialysis and kidney transplant patients. Clin J Am Soc Nephrol 2011; 6: 2208-2214.
20. Dikow R, Eckerle I, Ksoll-Rudek D et al. Immunogenicity and efficacy in hemodialysis patients of an AS03(A)-adjuvanted vaccine for 2009 pandemic influenza A(H1N1): a nonrandomized trial. Am J Kidney Dis 2011; 57: 716-723.
21. Labriola L, Hombrouck A, Marechal C et al. Immunogenicity of an adjuvanted 2009 pandemic influenza A (H1N1) vaccine in haemodialysed patients. Nephrol Dial Transplant 2011; 26: 1424-1428.
22. Edey M, Barraclough K, Johnson DW. Review article: hepatitis B and dialysis. Nephrology (Carlton) 2010; 15: 137-145.
23. Roman F, Vaman T, Gerlach B et al. Immunogenicity and safety in adults of one dose of influenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: preliminary report of an observer-blind, randomised trial. Vaccine 2010; 28: 1740-1745.
24. Allison AC, Eugui EM. Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection. Transplantation 2005; 80: S181-S190.