Suppression of the humoral immune response by mycophenolate mofetil

Nephrology Dialysis Transplantation

Volumn 13, Issue 1, 1998, Pages 160-164

  Smith, Kenneth G C ^a,b   Isbel, Nicole M ^a   Catton, Michael G ^c   Leydon, Jennie A ^c   Becker, Gavin J ^a   Walker, Rowan G ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c VICTORIAN INFECTIOUS DISEASES REFERENCE LABORATORY   (Australia)

Author keywords

Antibodies; Humoral immunity; Influenza vaccination; Mycophenolate mofetil; Renal transplantation

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INFLUENZA VACCINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE;

ADOLESCENT; ADULT; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMORAL IMMUNE DEFICIENCY; HUMORAL IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; INFLUENZA VACCINATION; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; RECIPIENT;

ADOLESCENT; ADULT; ANTIBODIES, VIRAL; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLUENZA VACCINES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MYCOPHENOLIC ACID;

EID: 0031983582     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.1.160     Document Type: Article

References (22)

1. Sintchak MD, Fleming MA, Futer O et al. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell 1996; 85: 921-930
2. Allison AC and Eugui EM. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant 1996; 10: 77-84
3. Allison AC and Eugui EM. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Imm Rev 1993; 136: 5-28
4. Taylor DO, Ensley RD, Olsen SL et al. Mycophenolate mofetil (RS-61443): preclinical, clinical, and three-year experience in heart transplantation. J Heart Lung Transplant 1994; 13: 571-582
5. European Mycophenolate Mofetil Cooperative Study Group. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 1995; 345: 1321-1325
6. The Tricontinental Mycophenolate Mofetil Renal Transplantation Study Group. A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. Transplantation 1996; 61: 1029-1037
7. Sollinger HW. Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. Transplantation 1995; 60: 225-232
8. Goldblum R. Therapy of rheumatoid arthritis with mycophenolate mofetil. Clin Exp Rheum 1993; 11 [Suppl 8]; S117-S119
9. Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol 1991; 33: 175-183
10. Figueroa J, Fuad SA, Kunjummen BD et al. Suppression of synthesis of natural antibodies by mycophenolate mofetil (RS-61443). Its potential use in discordant xenografting. Transplantation 1993; 55: 1371-1374
11. Soares MP, Latinne D, Elsen M et al. In vivo depletion of xenoreactive natural antibodies with an anti-μ monoclonal antibody. Transplantation 1993; 56: 1427-1433
12. Grailer A, Nichols J, Hullett D et al. Inhibition of human B cell responses in vitro by RS-61443, cyclosporine A and DAB486 IL-2. Transplant Proc 1991; 23: 314-315
13. Burlingham WJ, Grailer AP, Hullett DA et al Inhibition of both MLC and in vitro IgG memory response to tetanus toxoid by RS-61443. Transplantation 1991; 51: 545-547
14. Carroll RNP, Marsh SD, O'Donoghue EPN et al. Response to influenza vaccine by renal transplant patients. Br Med J 1974; 2: 701-703
15. Pabico RC, Douglas G, Betts RF et al. Antibody response to influenza vaccination in renal transplant patients. Ann Int Med 1976; 85: 431-436
16. Versluis DJ, Beyer WEP, Masurel N et al. Impairment of the immune response to influenza vaccination in renal transplant patients by cyclosporine, but not azalhioprine. Transplantation 1986; 42: 376-379
17. Rota PA, Regnery HL, Kendal AP. Influenza virus. In: Rose NR, de Marcario EC, Fahey J, Friedman H, Penn GM, eds. Manual of Clinical Laboratory Immunology, 4th edn. American Society for Microbiology, Washington DC: 1992; 576-581
18. Gluck R, Mischler R, Finkel B et al. Immunogenicity of new virosome influenza vaccine in elderly people. Lancet 1994; 344: 160-163
19. Briggs WA, Rozek RJ, Migdal SD et al Influenza vaccination in kidney transplant recipients: cellular and humoral immune responses. Ann Int Med 1980; 92: 471-477
20. Kimball JA, Pescovitz MD, Book BK et al. Reduced human IgG anti-ATGAM antibody formation in renal transplant recipients receiving mycophenolate mofetil. Transplantation 1996; 60: 1379-1383
21. Bohm M, Beissert S, Schwarz T, Metze D, Luger T. Bullous pemphigoid treated with mycophenolate mofetil. Lancet 1997; 349: 541
22. Nowack R, Birck R, van der Woude FJ. Mycophenolate mofetil for systemic vasculitis and IgA nephropathy. Lancet 1997; 349: 774