Effect of Oleo-gum-resin on ethanol-induced hepatotoxicity in rats

Journal of Medical Sciences (Faisalabad)

Volumn 12, Issue 1, 2012, Pages 1-9

  Al Rejaie, Salim S ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Commiphora molmol; Ethanol; Hepatic injury; Oleo gum resin

Indexed keywords

ACID PHOSPHATASE; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CHOLESTEROL; CINNAMALDEHYDE; DNA; ESSENTIAL OIL; EUGENOL; GLUTATHIONE; MALONALDEHYDE; NUCLEIC ACID; OLEO GUM RESIN; PLANT RESIN; RNA; SESQUITERPENE; SUPEROXIDE DISMUTASE; TERPENE; TERPENOID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACID PHOSPHATASE BLOOD LEVEL; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT DEFENSE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; COMMIPHORA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; ENZYME ACTIVITY; LIPID METABOLISM; LIVER INJURY; LIVER LEVEL; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLISM; NONHUMAN; OXIDATIVE STRESS; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84863303050     PISSN: 16824474     EISSN: 18125727     Source Type: Journal    
DOI: 10.3923/jms.2012.1.9     Document Type: Article

References (59)

1. AOAC, 1990. Official Methods of Analysis of the Association of Official Analytical Chemists. Association of Official Analytical Chemists, Washington, USA.
2. Abdel-Aziz, M.M., A.T. Abbas, K.A. Elbakry, E.A. Toson and M. El-Sherbiny, 2006. Immune response on mice infected with Schistosoma mansoni and treated with myrrh. J. Medical Sci., 6: 858-861.
3. Aebi, H., 1983. Catalase. In: Methods of Enzymatic Analysis, Bergmeyer, H. (Ed.). Verlag Chemie, Weinheim, Gemany, pp: 273-277.
4. Akira, T., S. Tanaka and M. Tabata, 1986. Pharmacological studies on the antiulcerogenic activity of chinese cinnamon. Planta Med., 52: 440-443.
5. Al-Harbi, M.M., S. Qureshi, M. Raza, M.M. Ahmed, M. Afzal and A.M. Shah, 1997. Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats. J. Ethanolpharmacol., 55: 141-150.
6. Al-Harbi, M.M., S. Qureshi, M.M. Ahmed, S. Rafatullah and A.H. Shah, 1994. Effect of Commiphora molmol (Oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice. Am. J. Chin. Med., 32: 77-82.
7. Albano, E., 2006. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc., 65: 278-290.
8. Alsaif, M.A., 2007. Effect of thymoquinone on ethanol-induced hepatotoxicity in Wistar rats. J. Med. Sci., 7: 1164-1170.
9. Amacher, D.E., 1998. Serum transaminase elevations as indicators of hepatic injury following the administration of drugs. Regul. Toxicol. Pharmacol., 27: 119-130.
10. Antonenkov, V.D. and L.F. Panchenko, 1988. Effect of chronic ethanol treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart. Int. J. Biochem., 20: 823-828.
11. Bailey, S.M. and C.C. Cunningham, 2002. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radical Biol. Med., 32: 11-16.
12. Baranisrinivasan, P., E.K. Elumalai, C. Sivakumar, S. Viviyan Therasa and E. David, 2009. Hepatoprotective effect of Enicostemma littorale blume and Eclipta alba during ethanol induced oxidative stress in albino rats. Int. J. Pharmacol., 5: 268-272.
13. Bregman, A.A., 1983. Laboratory Investigation and Cell Biology. John Wiley and Sons, New York, USA., ISBN-10: 047186241X, pp: 51-60.
14. Brieskorn, C.H. and P. Noble, 1982. Constituents of the essential oil of myrrh. Planta Med., 44: 87-90.
15. Bunout, D., 1999. Nutritional and metabolic effects of alcoholism: Their relationship with alcoholic liver disease. Nutrition, 15: 583-589.
16. Corrao, G., V. Bagnardi, A. Zambon and C. La Vecchia, 2004. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev. Med., 38: 613-619.
17. Crawford, D.W. and D.H. Blankenhorn, 1991. Arterial wall oxygenation, oxyradicals and atherosclerosis. Atherosclerosis, 89: 97-108.
18. De Duve, C. and P. Baudhuin, 1996. Peroxisomes (microbodies and related particles). Physiol. Rev., 46: 323-357.
19. Ebuehi, O.A.T. and C.L. Asonye, 2007. Gender and alcohol consumption affect human serum enzymes, protein and bilirubin. Asian J. Biochem., 2: 330-336.
20. Evans, W.C., 1989. Trease and Evans Pharmacognosy. 13th Edn., Balliere Tindall, London, ISBN: 0702013617, pp: 378-689.
21. Fang, Y.Z., S. Yang and G. Wu, 2002. Free radicals, antioxidants and nutrition. Nutrition, 18: 872-879.
22. Folch, J., M. Lees and G.H.S. Stanley, 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497-509.
23. Halliwell, B., 1991. Introduction to lee radicals in human disease. Saudi Med. J., 12: 13-19.
24. Handa, S.S. and A. Sharma, 1990. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbon tetrachloride. Indian J. Med. Res., 92: 276-283.
25. Ishii, H., J. Kurose and S. Kato, 1997. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress. J. Gastroenterol. Hepatol., 12: S272-S282.
26. Jurczuk, M., M.M. Brzoska, J. Moniuszko-Jakoniuk, M. Galazyn-Sidorszuk and E. Eulikowska-Karpinska, 2004. Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem. Toxicol., 42: 429-438.
27. Kakkar, P., B. Das and P.N. Viswanathan, 1984. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys., 21: 130-132.
28. Lee, J.S., 2004. Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clin. Chim. Acta, 347: 121-128.
29. Lykkesfeldt, J., 2007. Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking. Clin. Chim. Acta, 380: 50-58.
30. Malhotra, S.C., M.M. Ahuja and K.R. Sundaram, 1977. Long term clinical studies on the hypolipidemic effect of Commiphora mukul guggulu and clofibrate. Indian J. Med. Res., 65: 390-395.
31. Mates, J.M., C. Perez-Gomez and I.N. De Castro, 1999. Antioxidant enzymes and human diseases. Clin. Biochem., 32: 595-603.
32. McDonough, K.H., 2003. Antioxidant nutrients and alcohol. Toxicology, 189: 89-97.
33. Nencini, C., G.G. Franchi, F. Cavallo and L. Micheli, 2010. Protective effect of Allium neapolitanum Cyr. versus Allium sativum L. on acute ethanol-induced oxidative stress in rat liver. J. Med. Food, 13: 329-335.
34. Nityanand, S., J.S. Srivastava and O.P. Asthana, 1989. Clinical trials with gugulipid. A new hypolipidaemic agent. J. Assoc. Physicians India, 37: 323-328.
35. Ogunlade, B., L.C. Saalu, O.S. Ogunmodede, G.G. Akunna, O.A. Adeeyo and G.O. Ajayi, 2012. The salutary role of Allium cepa extract on the liver histology, liver oxidative status and liver marker enzymes of rabbits submitted to alcohol-induced toxicity. Am. J. Biochem. Mol. Biol., 2: 67-81.
36. Ohkawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
37. Pettit, G.R., 1978. Biosynthetie Produetsjbr Cancer Chenlotherapy. Plenum Press, New York, USA
38. Prakash, M., J.K. Shetty, S. Tripathy, M. Verma, S. Vasudev and P.V. Bhandary, 2008. Serum total Thiol status in alcohol abusers. Asian J. Biochem., 3: 48-51.
39. Qureshi, S., M.M. Al-Harbi, M.M. Ahmed, M. Raza, A.B. Giangreco and A.H. Shah, 1993. Evaluation of genotoxic, cytotoxic and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice. Cancer Chemother. Pharmacol., 33: 130-138.
40. Ramachandran, S., N. Rajendra Prasad, K.V. Pugalendi and V.P. Menon, 2008. Modulation of UVB-induced oxidative stress by ursolic acid in human blood lymphocytes. Asian J. Biochem., 3: 11-18.
41. Rao, R.M., Z.A. Khan and A.H. Shah, 2001. Toxicity studies in mice of Commiphora molmol oleo-gum resin. J. Ethnopharmacol., 76: 151-154.
42. Reddy, A.C.P. and B.R. Lokesh, 1992. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol. Cell. Biochem., 111: 117-124.
43. Rios, J.L., M.C. Recio, S. Manez and R.M. Giner, 2000. Natural Triterpenoids as Antiinflammatory Agents. In: Studies in Natural Products Chemistry: Bioactive Natural Products, Rahman, A. (Ed.). Elsevier, Amsterdam, The Netherlands, pp: 93-143.
44. Russo, D., V. Purohit, L. Foudin and M. Salin, 2004. Workshop on alcohol use and health disparities 2002: A call to arms. Alcohol, 32: 37-43.
45. Saka, W.A., R.E. Akhigbe, O.S. Ishola, E.A. Ashamu, O.T. Olayemi and G.E. Adeleke, 2011. Hepatotherapeutic effect of Aloe vera in alcohol-induced hepatic damage. Pak. J. Biol. Sci., 14: 742-746.
46. Schacterle, G.R. and R.L. Pollack, 1973. A simplified method for the quantitative assay of small amount of protein in biological material. Anal. Biochem., 51: 654-655.
47. Sedlak, J. and R.H. Lindsay, 1968. Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25: 192-205.
48. Shah, A.H., S. Qureshi, M. Tariq and A.M. Ageel, 1989. Toxicity studies on six plants used in the traditional arab system of medicine. Phytother. Res., 3: 25-29.
49. Sheela, C.G. and K.T. Augusti, 1992. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol., 30: 523-526.
50. Sheweita, S.A., M. Abd El-Gabar and M. Bastawy, 2001. Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: Role of antioxidants. Toxicology, 165: 217-224.
51. Singh, P.K., S. Roy and S. Dey, 2007. Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. Against ethanol-induced toxicity in mice. J. Ethnopharmacol., 111: 13-21.
52. Sofowora, A., 1982. Medicinal Plants and Traditional Medicine in Africa. Spectrum Books Limited, Ibadan, Nigria
53. Speisky, H., A. MacDonald, G. Giles, H. Orrego and Y. Israel, 1985. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration. Biochem. J., 225: 565-572.
54. Tadic, S., M.S. Elm, H.S. Li, G.J. Van Londen, V.M. Subbotin, D.C. Whitcomb and P.K. Eagon, 2002. Sex differences in hepatic gene expression in a rat model of ethanol-induced liver injury. J. Applied Physiol., 93: 1057-1068.
55. Thompson, D.C., D. Constantin-Teodosiu and P. Moldeus, 1991. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem. Biol. Interact., 77: 137-147.
56. Tripathi, Y.B., O.P. Malhotra and S.N. Tripathi, 1984. Thyroid stimulating action of z-guggulsterone obtained from commiphora mukul. Planta Med., 50: 78-80.
57. Vogt, B.L. and J.P. Richie Jr., 2007. Glutathione depletion and recovery after acute ethanol administration in the aging mouse. Biochem. Pharmacol., 73: 1613-1621.
58. Wu, G., Y.Z. Fang, S. Yang, J.R. Lupton and N.D. Turner, 2004. Glutathione metabolism and its implications for health. J. Nutr., 134: 489-492.
59. Zeng, T., F.F. Guo, C.L. Zhang, S. Zhao, D.D. Dou, X.C. Gao and K.Q. Xie, 2008. The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice. Chem. Biol. Interact., 176: 234-242.