BC047440 antisense eukaryotic expression vectors inhibited HepG2 cell proliferation and suppressed xenograft tumorigenicity

Brazilian Journal of Medical and Biological Research

Volumn 45, Issue 2, 2012, Pages 97-103

  Zheng, Lu ^a   Liang, Ping ^a   Zhou, Jian Bo ^a   Huang, Xiao Bing ^a   Wen, Yu ^b   Wang, Zheng ^a   Li, Jing ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Chongqing Third People's Hospital   (China)

Author keywords

Antisense eukaryotic expression vector; BC047440; Cell proliferation; Hepatocellular carcinoma; Tumorigenicity

Indexed keywords

BC047440; COMPLEMENTARY DNA; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISENSE VECTOR; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; EXPRESSION VECTOR; GENE INSERTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

EUKARYOTA; MUS MUSCULUS;

EID: 84863291192     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2012007500001     Document Type: Article

References (13)

1. Kew MC. Epidemiology of hepatocellular carcinoma. Toxicology 2002; 181-182: 35-38.
2. Bosch FX, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis 1999; 19: 271-285.
3. Hayashi PH, Zeldis JB. Molecular biology of viral hepatitis and hepatocellular carcinoma. Compr Ther 1993; 19: 188-196.
4. Ozturk M. Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis 1999; 19: 235-242.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A 2002; 99: 16899-16903.
6. Li J, Han BL, Huang GJ, Qian GS, Liang P, Yang TH, et al. [Screening and identification for cDNA of differentially expressed genes in human primary hepatocellular carcinoma]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003; 20: 49-52.
7. Zhao HZ, Liang P, Li J, Li HY, Huang XB. Rapid cloning and expression of hepatocellular carcinoma associated cDNA fragments. World Chin J Dig 2004; 12: 1785-1788.
8. Zhao HZ, Li J, Liang P, Li HY, Huang XB. [Molecular cloning and identification of a novel gene and its relationship to hepatocellular carcinoma]. Zhonghua Gan Zang Bing Za Zhi 2005; 13: 483, 487.
9. Zheng L, Huang X, Liang P, Wen Y, Yang T, Li Y, et al. BC047440 overexpression is a risk factor for tumor invasion and poor prognosis in hepatocellular carcinoma. Hepatogastroenterology 2010; 57: 919-925.
10. Zheng L, Liang P, Li J, Huang XB, Wang WW, Wang L, et al. Expression of BC047440 protein in hepatocellular carcinoma and its relationship to prognosis. Chin J Cancer 2010; 29: 931-936.
11. Zeng JZ, Wang HY, Chen ZJ, Ullrich A, Wu MC. Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma. Oncogene 2002; 21: 4932-4943.
12. Shostak K, Labunskyy V, Dmitrenko V, Malisheva T, Shamayev M, Rozumenko V, et al. HC gp-39 gene is upregulated in glioblastomas. Cancer Lett 2003; 198: 203-210.
13. Yamamoto Y, Sakamoto M, Fujii G, Kanetaka K, Asaka M, Hirohashi S. Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma. Clin Cancer Res 2001; 7: 297-303.