Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 8, 2011, Pages 2031-2037

  Xu, Weizhuo ^a   Zhou, Lina ^a   Ma, Xiaonan ^a   Chen, Yinan ^a   Qin, Bin ^a   Zhai, Xingwen ^a   You, Song ^a  

^a Department of Life Science and Biopharmaceutics   (Switzerland)

Author keywords

Albiflorin; Hematopoietic; Leukocytotic; Myelosuppression; Paeoniflorin; Thrombocytopoietic

Indexed keywords

EID: 84863291190     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hsu FL, Lai CW and Cheng JT (1997). Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med, 63, 323-5.
2. International Committee for Standardization in Haematology (1965). International Committee for Standardization in Haematology of the European Society of Haematology: Recommendations and requirements for haemoglobinometry in human blood. J Clin Pathol, 18, 353-5.
3. Ishida H, Takamatsu M, Tsuji K and Kosuge T (1987). Studies on active substances in herbs used for oketsu ("stagnant blood") in Chinese medicine. V. On the anticoagulative principle in moutan cortex. Chem Pharm Bull (Tokyo), 35, 846-8.
4. Kaneda M, Iitaka Y, Shibata S (1972). Chemical studies on the oriental plant drugs-XXXIII: The absolute structures of paeoniflorin, albiflorin, oxypaeoniflorin and benzoylpaeoniflorin isolated from chinese paeony root. Tetrahedron, 28, 4309-17.
5. Kimura M, Kimura I, Nojima H (1985). Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin. Jpn J Pharmacol, 37, 395-9.
6. Kobayashi M, Ueda C, Aoki S, et al. (1990). Anticholinergic action of Paeony root and its active constituents. Yakugaku Zasshi, 110, 964-8 (in Japanese).
7. Liu DZ, Xie KQ, Ji XQ, et al (2005). Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. Br J Pharmacol, 146, 604-11.
8. Murakami N, Saka M, Shimada H, et al (1996). New bioactive monoterpene glycosides from Paeoniae radix. Chem Pharm Bull, 44, 1279-81.
9. Ohta H, Matsumoto K, Watanabe H, Shimizu M (1993). Involvement of beta-adrenergic systems in the antagonizing effect of paeoniflorin on the scopolamine-induced deficit in radial maze performance in rats. Jpn J Pharmacol, 62, 345-9.
10. Okubo T, Nagai F, Seto T, et al (2000). The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan cortex and Paeoniae radix. Biol Pharm Bull, 23, 199-203.
11. Shibata S and Nakahara M (1963). Studies on the constituents of Japanese and Chinese crude drugs. VIII. Paeoniflorin, A Glucoside of Chinese Paeony Root. (1). Chem Pharmaceutical Bull, 11, 372-8.
12. Wu H, Wei W, Song L, et al (2007). Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol, 7, 662-73.
13. Xu HM, Wei W, Jia XY, et al (2007). Effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats. J Ethnopharmacol, 109, 442-8.
14. Xu S, Bian R, Chen X (2002). Pharmacology Experiment Methodology. Beijing, People's Medical Publishing House.
15. Yamahara J, Yamada T, Kimura H, et al. (1982). Biologically active principles of crude drugs. II. Anti-allergic principles in "Shoseiryu-To" anti-inflammatory properties of paeoniflorin and its derivatives. J Pharmacobiodyn, 5, 921-9.
16. You S, Liang S, Ren J, Lv X (2002). The preparation of the combination of paeoniflorin and albiflorin. Patent. CN 02133298.3.