Preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions

Journal of Biomedical Optics

Volumn 17, Issue 2, 2012, Pages

  Yan, Jun ^a,c   Zhuo, Shuangmu ^b   Chen, Gang ^c   Wu, Xiufeng ^c   Zhou, Dong ^c   Xie, Shusen ^b   Jiang, Jiahao ^a   Ying, Mingang ^c   Jia, Fan ^a   Chen, Jianxin ^b   Zhou, Jian ^a  

^a FUDAN UNIVERSITY   (China)

^b FUJIAN NORMAL UNIVERSITY   (China)

^c FUJIAN PROVINCIAL TUMOR HOSPITAL   (China)

Author keywords

liver cancer; liver lesions; multiphoton microscopy; optical diagnosis; pathology

Indexed keywords

CANCER CELLS; CELL MORPHOLOGY; CLINICAL USE; DIAGNOSTIC FEATURES; HIGH RESOLUTION; LIVER CANCERS; MULTI-PHOTON MICROSCOPY; MULTIPHOTONS; NONINVASIVE OPTICAL BIOPSY; OPTICAL BIOPSIES; OPTICAL DIAGNOSIS; OPTICAL DIAGNOSTICS; PILOT STUDIES; PRECLINICAL STUDIES; SIZE AND SHAPE; SURGICAL SPECIMENS; TISSUE ARCHITECTURE;

BIOPSY; ENDOSCOPY; PATHOLOGY;

DISEASES;

ADULT; AGED; ARTICLE; CLASSIFICATION; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; LIVER TUMOR; MALE; METHODOLOGY; MIDDLE AGED; MULTIPHOTON MICROSCOPY; PATHOLOGY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MIDDLE AGED; SENSITIVITY AND SPECIFICITY;

EID: 84863277598     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.2.026004     Document Type: Article

References (23)

1. Marsh, J. W. and I. Dvorchik, Should we biopsy each liver mass suspicious for hepatocellular carcinoma before liver transplantation?-Yes., J. Hepatol. 43 (4), 558-562 (2005). JOHEEC 0168-8278 10.1016/j.jhep.2005.07.014
2. Silva, M. A. et al., Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis., Gut. 57 (11), 1592-1596 (2008). GUTTAK 0017-5749 10.1136/gut.2008.149062
3. Rowe, L. R. et al., Subcutaneous tumor seeding following needle core biopsy of hepatocellular carcinoma., Diagn. Cytopathol. 35 (11), 717-721 (2007). DICYE7 1097-0339 10.1002/(ISSN)1097-0339
4. Jones, O. M. et al., Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver resection., Br. J. Surg. 92 (9), 1165-1168 (2005). BJSUAM 0007-1323 10.1002/(ISSN)1365-2168
5. Louha, M. et al., Liver resection and needle liver biopsy cause hematogenous dissemination of liver cells., Hepatology 29 (3), 879-882 (1999). HEPADF 0161-0538 10.1002/(ISSN)1527-3350
6. Zipfel, W. R., R. M. Williams and W. W. Webb, Nonlinear magic: multiphoton microscopy in the biosciences., Nat. Biotechnol. 21 (11), 1369-1377 (2003). NABIF9 1087-0156 10.1038/nbt899
7. Helmchen, F. and W. Denk, Deep tissue two-photon microscopy., Nat. Methods. 2 (12), 932-940 (2005). 1548-7091 10.1038/nmeth818
8. Kurtz, R. et al., Application of multiline two-photon microscopy to functional in vivo imaging., J. Neurosci. Meth. 151 (2), 276-286 (2006). JNMEDT 0165-0270 10.1016/j.jneumeth.2005.12.003
9. Zipfel, W. R. et al., Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation., Proc. Natl. Acad. Sci. 100 (12), 7075-7080 (2003). PNASA6 0027-8424 10.1073/pnas.0832308100
10. Skala, M. C. et al., In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia., Proc. Natl. Acad. Sci. 104 (49), 19494-19499 (2007). PNASA6 0027-8424 10.1073/pnas.0708425104
11. Skala, M. and N. Ramanujam, Multiphoton redox ratio imaging for metabolic monitoring in vivo., Methods Mol. Biol. 594 (1), 155-162 (2010). MMBIED 0097-0816
12. Helmchen, F. et al., A miniature head-mounted two-photon microscope: high resolution brain imaging in freely moving animals., Neuron. 31 (6), 903-912 (2001). NERNET 0896-6273 10.1016/S0896-6273(01)00421-4
13. Helmchen, F. and W. Denk, New developments in multiphoton microscopy., Curr. Opin. Neurobiol. 12 (5), 593-601 (2002). COPUEN 0959-4388 10.1016/S0959-4388(02)00362-8
14. Tang, S. et al., Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning., J. Biomed. Opt. 14 (3), 034005 (2009). JBOPFO 1083-3668 10.1117/1.3127203
15. Bao, H. and M. Gu, A 0.4-mm-diameter probe for nonlinear optical imaging., Opt. Express. 17 (12), 10098-10104 (2009). OPEXFF 1094-4087 10.1364/OE.17.010098
16. Liu, G. et al., Rotational multiphoton endoscopy with a 1 microm fiber laser system., Opt. Lett. 34 (15), 2249-2251 (2009). OPLEDP 0146-9592 10.1364/OL.34.002249
17. Jung, J. C. and M. J. Schnitzer, Multiphoton endoscopy., Opt. Lett. 28 (11), 902-904 (2003). OPLEDP 0146-9592 10.1364/OL.28.000902
18. Bird, D. and M. Gu, Two-photon fluorescence endoscopy with a micro-optic scanning head., Opt. Lett. 28 (17), 1552-1554 (2003). OPLEDP 0146-9592 10.1364/OL.28.001552
19. Koehler, M. J. et al., In vivo assessment of human skin aging by multiphoton laser scanning tomography., Opt. Lett. 31 (19), 2879-2881 (2006). OPLEDP 0146-9592 10.1364/OL.31.002879
20. Knig, K., Clinical multiphoton tomography., J. Biophotonics 1 (1), 13-23 (2008). 10.1002/jbio.200710022
21. Zhuo, S. et al., Multimode nonlinear optical imaging of the dermis in ex vivo human skin based on the combination of multichannel mode and Lambda mode., Opt. Express. 14 (17), 7810-7820 (2006). OPEXFF 1094-4087 10.1364/OE.14.007810
22. Jemal, A. et al., Global cancer statistics., CA. Cancer. J. Clin. 61 (2), 69-90 (2011). CAMCAM 0007-9235 10.3322/caac.v61:2
23. Ouzounov, D. G. et al., Delivery of nanojoule femtosecond pulses through large-core microstructured fibers., Opt. Lett. 27 (17), 1513-1515 (2002). OPLEDP 0146-9592 10.1364/OL.27.001513