Intervention of azithromycin on Pseudomonas aeruginosa biofilm and virulence factors

Chinese Journal of Microbiology and Immunology

Volumn 30, Issue 11, 2010, Pages 1020-1024

  Jian, Li Juan ^a   Chen, Yi Qiang ^a   Wen, Hong Xia ^a   Kong, Jin Liang ^a   Yan, Ping ^a   Zhang, Dong Wei ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Azithromycin; Biofilm; Pseudomonas aeruginosa; Virulence factors

Indexed keywords

AZITHROMYCIN; CASEIN; CONGO RED; CRYSTAL VIOLET; ELASTIN; ORCINOL; PROTEINASE; PYOVERDINE; RHAMNOLIPID; VIRULENCE FACTOR;

ARTICLE; BACTERIAL COUNT; BACTERIUM ADHERENCE; BIOFILM; CONTROLLED STUDY; DILUTION; ELASTOLYSIS; ENZYME ACTIVITY; IN VITRO STUDY; NONHUMAN; PSEUDOMONAS AERUGINOSA; SCANNING ELECTRON MICROSCOPE;

EID: 84863270503     PISSN: 02545101     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0254-5101.2010.11.011     Document Type: Article

References (10)

1. Hassett D J, Korfhagen T R, Irvin R T, et al. Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies. Expert Opin Ther Targets, 2010, 14(2): 117-130.
2. Jackson K D, Starkey M, Kremer S, et al. Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J Bacteriol, 2004, 186(14): 4466-475.
3. Hoffmann N, Lee B, Hentzer M, et al. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. Antimicrob Agents Chemother, 2007, 51(10): 3677-3687.
4. Hentzer M, Riedel K, Rasmussen T B, et al. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology, 2002, 148(Pt 1): 87-102.
5. Pham T H, Webb J S, Rehm B H. The role of polyhydroxyalkanoate biosynthesis by Pseudomonas aeruginosa in rhamnolipid and alginate production as well as stress tolerance and biofilm formation. Microbiology, 2004, 150(Pt 10): 3405-3413.
6. Winstanley C, Fothergill J L. The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol Lett, 2009, 290(1): 1-9.
7. Skindersoe M E, Alhede M, Phipps R, et al. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother, 2008, 52(10): 3648-3663.
8. Mulet X, Maciá M D, Mena A, et al. Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants. Antimicrob Agents Chemother, 2009, 53(4): 1552-1560.
9. Gillis R J, Iglewski B H. Azithromycin retards Pseudomonas aeruginosa biofilm formation. J Clin Microbiol, 2004, 42(12): 5842-5845.
10. Caiazza N C, Shanks R M, O'Toole G A. Rhamnolipids modulate swarming motility patterns of Pseudomonas aeruginosa. J Bacteriol, 2005, 187(21): 7351-7361.