Combination of nifedipine and subtherapeutic dose of cyclosporin additively suppresses mononuclear cells activation of patients with rheumatoid arthritis and normal individuals via Ca 2+-calcineurin-nuclear factor of activated T cells pathway

Clinical and Experimental Immunology

Volumn 168, Issue 1, 2012, Pages 78-86

  Lai, N S ^a,c   Yu, C L ^d   Yin, W Y ^a   Yu, H C ^a   Huang, H B ^b   Tung, C H ^a   Lu, M C ^a,c  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^c TZU CHI UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Calcineurin; Calcium channel blocker; Cyclosporin; Nuclear factor of activated T cells; Rheumatoid arthritis

Indexed keywords

CALCINEURIN; CALCIUM ION; CD28 ANTIGEN; CD3 ANTIGEN; CYCLOSPORIN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; NIFEDIPINE; TRANSCRIPTION FACTOR NFAT;

ADULT; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ACTIVATION; CELL ACTIVITY; CELL PROLIFERATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOSOL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION; TH2 CELL;

ADULT; AGED; APOPTOSIS; ARTHRITIS, RHEUMATOID; CALCINEURIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CYCLOSPORINE; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NFATC TRANSCRIPTION FACTORS; NIFEDIPINE; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84863269137     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04563.x     Document Type: Article

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