Disruptions of functional connectivity in the default mode network of comatose patients

Neurology

Volumn 78, Issue 3, 2012, Pages 175-181

  Norton, L ^a   Hutchison, R M ^a   Young, G B ^a   Lee, D H ^a   Sharpe, M D ^a   Mirsattari, S M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AWARENESS; BRAIN REGION; CLINICAL ARTICLE; COMATOSE PATIENT; CONSCIOUSNESS; CONTROLLED STUDY; DEFAULT MODE NETWORK; EVOKED SOMATOSENSORY RESPONSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GLASGOW COMA SCALE; GLASGOW OUTCOME SCALE; HEART ARREST; HUMAN; INDEPENDENT COMPONENT ANALYSIS; MALE; MENTAL FUNCTION; PRIORITY JOURNAL; BIOLOGICAL MODEL; BRAIN CORTEX; COMA; MIDDLE AGED; NERVE CELL NETWORK; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY;

ADULT; CEREBRAL CORTEX; COMA; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; NERVE NET; NEURAL PATHWAYS;

EID: 84863267602     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31823fcd61     Document Type: Article

References (39)

1. Posner JB, Saper CB, Schiff N, Plum F. Plum and Posner's Diagnosis of Stupor and Coma. New York: Oxford University Press; 2007.
2. Coleman MR, Davis MH, Rodd JM, et al. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain 2009;132:2541-2552.
3. Di H, Boly M, Weng X, Ledoux D, Laureys S. Neuroimaging activation studies in the vegetative state: predictors of recovery? Clin Med 2008;8:502-507.
4. Gofton TE, Chouinard PA, Young GB, et al. Functional MRI study of the primary somatosensory cortex in comatose survivors of cardiac arrest. Exp Neurol 2009;217: 320-327.
5. Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea. Neuroimage 2007;37: 1083-1090; discussion 1097-1099.
6. Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, Macrae CN. Wandering minds: the default network and stimulus-independent thought. Science 2007;315:393-395. (Pubitemid 46175523)
7. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann NY Acad Sci 2008;1124:1-38. (Pubitemid 351506788)
8. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci USA 2001;98:676-682. (Pubitemid 32105102)
9. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003; 100:253-258. (Pubitemid 36078061)
10. Greicius M. Resting-state functional connectivity in neuropsychiatric disorders. Curr Opin Neurol 2008;21:424-430.
11. Boly M, Phillips C, Tshibanda L, et al. Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Ann NY Acad Sci 2008;1129:119-129. (Pubitemid 351990285)
12. McKiernan KA, D'Angelo BR, Kaufman JN, Binder JR. Interrupting the "stream of consciousness": an fMRI investigation. Neuroimage 2006;29:1185-1191. (Pubitemid 43184181)
13. Cauda F, Micon BM, Sacco K, et al. Disrupted intrinsic functional connectivity in the vegetative state. J Neurol Neurosurg Psychiatry 2009;80:429-431.
14. Vanhaudenhuyse A, Noirhomme Q, Tshibanda LJ, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010;133:161-171.
15. Boly M, Tshibanda L, Vanhaudenhuyse A, et al. Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum Brain Mapp 2009;30:2393-2400.
16. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975;1:480-484.
17. Calhoun VD, Adali T, Pearlson GD, Pekar JJ. A method for making group inferences from functional MRI data using independent component analysis. Hum Brain Mapp 2001;14:140-151. (Pubitemid 33032347)
18. Bluhm RL, Osuch EA, Lanius RA, et al. Default mode network connectivity: effects of age, sex, and analytic approach. Neuroreport 2008;19:887-891. (Pubitemid 351655161)
19. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry 2007;164: 450-457. (Pubitemid 46513159)
20. Greicius MD, Kiviniemi V, Tervonen O, et al. Persistent default-mode network connectivity during light sedation. Hum Brain Mapp 2008;29:839-847. (Pubitemid 351813085)
21. Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain. Nature 2007;447:83-86. (Pubitemid 46685840)
22. Tshibanda L, Vanhaudenhuyse A, Boly M, et al. Neuroimaging after coma. Neuroradiol 2010;52:15-24.
23. Young GB. Clinical practice: neurologic prognosis after cardiac arrest. N Engl J Med 2009;361:605-611.
24. Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S, Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology. Neurology 2006;67:203-210. (Pubitemid 44305400)
25. Baars BJ, Ramsoy TZ, Laureys S. Brain, conscious experience and the observing self. Trends Neurosci 2003;26: 671-675. (Pubitemid 37415018)
26. Baars BJ. Global workspace theory of consciousness: toward a cognitive neuroscience of human experience. Prog Brain Res 2005;150:45-53. (Pubitemid 41381544)
27. Laureys S, Boly M, Maquet P. Tracking the recovery of consciousness from coma. J Clin Invest 2006;116:1823- 1825.
28. Auer DP. Spontaneous low-frequency blood oxygenation level-dependent fluctuations and functional connectivity analysis of the 'resting' brain. Magn Reson Imaging 2008; 26:1055-1064.
29. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron 2009;62:42-52.
30. Sporns O. Networks of the Brain. Cambridge, MA: The MIT Press; 2010.
31. Greicius MD, Srivastava G, Reiss AL, Menon V. Defaultmode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci USA 2004;101:4637-4642. (Pubitemid 38437463)
32. Sorg C, Riedl V, Muhlau M, et al. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci USA 2007;104: 18760-18765. (Pubitemid 350210770)
33. Sporns O, Honey CJ, Kotter R. Identification and classification of hubs in brain networks. PLoS One 2007;2: e1049.
34. Hagmann P, Cammoun L, Gigandet X, et al. Mapping the structural core of human cerebral cortex. PLoS Biol 2008; 6:e159.
35. Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci 2009;29:1860-1873.
36. Skudlarski P, Jagannathan K, Calhoun VD, Hampson M, Skudlarska BA, Pearlson G. Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations. Neuroimage 2008;43:554-561.
37. Honey CJ, Sporns O, Cammoun L, et al. Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci USA 2009;106:2035-2040.
38. Margulies DS, Vincent JL, Kelly C, et al. Precuneus shares intrinsic functional architecture in humans and monkeys. Proc Natl Acad Sci USA 2009;106:20069-20074.
39. Kelly C, Uddin LQ, Shehzad Z, et al. Broca's region: Linking human brain functional connectivity data and nonhuman primate tracing anatomy studies. Eur J Neurosci 2010;32:383-398.