Left ventricular mechanical dyssynchrony impairs exercise capacity in patients with coronary artery disease with preserved left ventricular systolic function and a QRS duration ≤120 ms

Circulation Journal

Volumn 76, Issue 3, 2012, Pages 682-688

  Wang, Mei ^a,b   Yan, Guo Hui ^a   Yue, Wen Sheng ^a   Siu, Chung Wah ^a,b   Yiu, Kai Hang ^a   Lee, Stephen W L ^a   Lau, Chu Pak ^a   Tse, Hung Fat ^a,b  

^a QUEEN MARY HOSPITAL   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Coronary artery disease; Exercise capacity; Left ventricular dyssynchrony; Myocardial infarction; Regional wall motion abnormality

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BLOOD FLOW VELOCITY; BODY MASS; CORONARY ARTERY DISEASE; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EXERCISE; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MECHANICAL DYSSYNCHRONY; HEART MUSCLE REVASCULARIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC EQUIVALENT; MITRAL VALVE; QRS COMPLEX; TREADMILL EXERCISE;

AGE FACTORS; AGED; CORONARY ARTERY DISEASE; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SEX FACTORS; SYSTOLE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84863254532     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-11-0735     Document Type: Article

References (35)

1. Yu CM, Lin H, Zhang Q, Sanderson JE. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart 2003; 89: 54-60.
2. Lee PW, Zhang Q, Yip GWK, Wu LW, Lam YL, Wu EB, et al. Left ventricular systolic and diastolic dyssynchrony in coronary artery disease with preserved ejection fraction. Clinical Science 2009; 116: 521-529.
3. Baldasseroni S, Opasich C, Gorini M, Lucci D, Marchionni N, Marini M, et al. Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: A report from the Italian network on congestive heart failure. Am Heart J 2002; 143: 398-405.
4. Duncan AM, Francis DP, Gibson DG, Henein MY. Limitation of exercise tolerance in chronic heart failure: Distinct effects of left Bundle-Branch block and coronary artery disease. J Am Coll Cardiol 2004; 43: 1524-1531.
5. Kanzaki H. Mechanical dyssynchrony is not everything of substrate but is essential for cardiac resynchronization therapy. Circ J 2011; 75: 457-464.
6. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Eng J Med 2002; 346: 793-801.
7. Ariyarajah V, Kranis M, Apiyasawat S, Spodick DH. Association of myocardial ischemia and coronary angiographic lesions with increased left atrial dimension during exercise tolerance tests among patients without known coronary heart disease. Am J Cardiol 2007; 99: 1187-1192.
8. Donal E, Raud-Raynier P, De Place C, Gervais R, Rosier A, Roulaud M, et al. Resting echocardiographic assessments of left atrial function and filling pressure interest in the understanding of exercise capacity in patients with chronic congestive heart failure. J Am Soc Echocardiog 2008; 21: 703-710.
9. Gardin JM, Leifer ES, Fleg JL, Whellan D, Kokkinos P, LeBlanc MH, et al. Relationship of Doppler-Echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: The HF-ACTION study. Am Heart J 2009; 158: S45-S52.
10. Johnson NP, Wu E, Bonow RO, Holly TA. Relation of exercise capacity and body mass index to mortality in patients with intermediate to high risk of coronary artery disease. Am J Cardiol 2008; 102: 1028-1033.
11. Lapu-Bula R, Robert A, De Kock M, D'Hondt AM, Detry JM, Melin JA, et al. Relation of exercise capacity to left ventricular systolic function and diastolic filling in idiopathic or ischemic dilated cardiomyopathy. Am J Cardiol 1999; 83: 728-734.
12. Podolec P, Rubis P, Tomkiewicz-Pajak L, Kopec G, Tracz W. Usefulness of the evaluation of left ventricular diastolic function changes during stress echocardiography in predicting exercise capacity in patients with ischemic heart failure. J Am Soc Echocardiog 2008; 21: 834-840.
13. Sakate Y, Yoshiyama M, Hirata K, Fujita H, Takeuchi K, Tachibana K, et al. Relationship between Doppler-derived left ventricular diastolic function and exercise capacity in patients with myocardial infarction. Jpn Circ J 2001; 65: 627-631.
14. Schiller NB. Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass: Summary and discussion of the 1989 recommendations of the American Society of Echocardiography. Circulation 1991; 84(Suppl 3): 1280-1287.
15. Leite-Moreira AF. Current perspectives in diastolic dysfunction and diastolic heart failure. Heart 2006; 92: 712-718.
16. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiog 1989; 2: 358-367.
17. Gibbons RJ, Balady GJ, Beasley JW, Faafp JW, Bricker JT, Duvernoy WFC, et al. ACC/AHA Guidelines for exercise testing: Executive Summary: A report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on Exercise Testing). Circulation 1997; 96: 345-354.
18. Gulati M, Pandey DK, Arnsdorf MF, Lauderdale DS, Thisted RA, Wicklund RH, et al. Exercise capacity and the risk of death in women: The St James Women Take Heart Project. Circulation 2003; 108: 1554-1559.
19. Wang J, Abraham TP, Korinek J, Urheim S, McMahon EM, Belohlavek M. Delayed onset of subendocardial diastolic thinning at rest identifies hypoperfused myocardium. Circulation 2005; 111: 2943-2950.
20. Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD, et al. Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium. Am J Physiol Heart Circ Physiol 1997; 273: H2146-H2154.
21. Lin FC, Chang SH, Hsieh IC, Hung KC, Yeh SJ, See LC, et al. Time to peak velocity measurements by pulsed wave Doppler tissue imaging to quantify ischemia-related regional myocardial asynchrony. J Am Soc Echocardiog 2004; 17: 299-306.
22. Kass DA. An epidemic of dyssynchrony: But what does it mean? J Am Coll Cardiol 2008; 51: 12-17.
23. Turner MS, Bleasdale RA, Vinereanu D, Mumford CE, Paul V, Fraser AG, et al. Electrical and mechanical components of dyssynchrony in heart failure patients with normal QRS duration and left bundlebranch block. Circulation 2004; 109: 2544-2549.
24. Pai RG, Gill KS. Amplitudes, durations, and timings of apically directed left ventricular myocardial velocities: II. Systolic and diastolic asynchrony in patients with left ventricular hypertrophy. J Am Soc Echocardiog 1998; 11: 112-118.
25. Weber KT, Anversa P, Amstrong PW, Brilla CG, Burnett JCJ, Cruickshank JM, et al. Remodeling and reparation of the cardiovascular system. J Am Coll Cardiol 1992; 20: 3-16.
26. Popovi ZB, Griffin B. Diastolic stress testing: A new trick to evaluate the ageing heart. Heart 2010; 96: 906-907.
27. Tan YT, Wenzelburger F, Lee E, Heatlie G, Frenneaux M, Sanderson JE. Abnormal left ventricular function occurs on exercise in welltreated hypertensive subjects with normal resting echocardiography. Heart 2010; 96: 948-955.
28. Tan YT, Wenzelburger F, Lee E, Heatlie G, Leyva F, Patel K, et al. The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. J Am Coll Cardiol 2009; 54: 36-46.
29. Wang M, Yip G, Yu CM, Zhang Q, Zhang Y, Tse D, et al. Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function. J Am Coll Cardiol 2005; 45: 272-277.
30. Wang M, Yip GWK, Wang AYM, Zhang Y, Ho PY, Tse MK, et al. Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value. J Am Coll Cardiol 2003; 41: 820-826.
31. Horwich TB, Leifer ES, Brawner CA, Fitz-Gerald MB, Fonarow GC. The relationship between body mass index and cardiopulmonary exercise testing in chronic systolic heart failure. Am Heart J 2009; 158: S31-S36.
32. Shubair M, Kodis J, McKelvie RS, Arthur HM, Sharma AM. Metabolic profile and exercise capacity outcomes: Their relationship to overweight and obesity in a Canadian Cardiac Rehabilitation Setting. J Cardiopulm Rehabil 2004; 24: 405-413.
33. Diercks DB, Roe MT, Mulgund J, Pollack JCV, Kirk JD, Gibler WB, et al. The obesity paradox in non-ST-segment elevation acute coronary syndromes: Results from the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart Association Guidelines Quality Improvement Initiative. Am Heart J 2006; 152: 140-148.
34. Gruberg L, Mercado N, Milo S, Boersma E, Disco C, van Es GA, et al. Impact of body mass index on the outcome of patients with multivessel disease randomized to either coronary artery bypass grafting or stenting in the ARTS trial: The obesity paradox II? Am J Cardiol 2005; 95: 439-444.
35. Minutello RM, Chou ET, Hong MK, Bergman G, Parikh M, Iacovone F, et al. Impact of body mass index on In-Hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry). Am J Cardiol 2004; 93: 1229-1232.