Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 3, 2012, Pages 923-932

  Chen, Hui ^a   Guo, Jing Hui ^a   Lu, Yong Chao ^a,b   Ding, Guo Lian ^b   Yu, Mei Kuen ^a   Tsang, Lai Ling ^a   Fok, Kin Lam ^a   Liu, Xin Mei ^a,b   Zhang, Xiao Hu ^a   Chung, Yiu Wa ^a   Huang, Pingbo ^e   Huang, Hefeng ^b   Chan, Hsiao Chang ^a,c,d  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b ZHEJIANG UNIVERSITY   (China)

^c JINAN UNIVERSITY   (China)

^d CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^e HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AROMATASE; BICARBONATE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTRADIOL; ESTROGEN; FOLLITROPIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; ESTROGEN SYNTHESIS; FEMALE; GRANULOSA CELL; HUMAN; HUMAN CELL; MOUSE; MOUSE MUTANT; NONHUMAN; OVARY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SENSOR;

ANIMALS; AROMATASE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYSTIC FIBROSIS; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; GRANULOSA CELLS; MICE; MICE, INBRED ICR; PHOSPHORYLATION; POLYCYSTIC OVARY SYNDROME; RATS; RATS, SPRAGUE-DAWLEY;

MUS; RODENTIA;

EID: 84863250962     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1363     Document Type: Article

References (39)

1. Payne AH, Hales DB 2004 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947-970 (Pubitemid 39657774)
2. Stocco C 2008 Aromatase expression in the ovary: hormonal and molecular regulation. Steroids 73:473-487
3. Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J 2000 Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor [see comment]. Science 289:625-628 (Pubitemid 30622067)
4. Zippin JH, Farrell J, Huron D, Kamenetsky M, Hess KC, Fischman DA, Levin LR, Buck J 2004 Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol 164:527-534 (Pubitemid 38233314)
5. Sayner S, Stevens T 2006 Soluble adenylate cyclase reveals the significance of compartmentalized cAMP on endothelial cell barrier function. Biochem Soc Trans 34:492-494 (Pubitemid 44230744)
6. Xie F, Garcia MA, Carlson AE, Schuh SM, Babcock DF, Jaiswal BS, Gossen JA, Esposito G, van Duin M, Conti M 2006 Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol 296:353-362 (Pubitemid 44209250)
7. Baudouin-Legros M, Hamdaoui N, Borot F, Fritsch J, Ollero M, Planelles G, Edelman A 2008 Control of basal CFTR gene expression by bicarbonate-sensitive adenylyl cyclase in human pulmonary cells. Cell Physiol Biochem 21:75-86
8. Kumar S, Kostin S, Flacke JP, Reusch HP, Ladilov Y 2009 Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J Biol Chem 284:14760-14768
9. Sheppard DN, Welsh MJ 1999 Structure and function of the CFTR chloride channel. Physiol Rev 79:S23-S45 (Pubitemid 29058908)
10. Illek B, Yankaskas JR, Machen TE 1997 cAMP and genistein stimulate HCO3-conductance through CFTR in human airway epithelia. Am J Physiol 272:L752-L761
11. Jarzabek K, Zbucka M, Pepiñski W, Szamatowicz J, Domitrz J, Janica J, Wołczyñski S, Szamatowicz M 2004 Cystic fibrosis as a cause of infertility. Reprod Biol 4:119-129
12. Johannesson M, Landgren BM, Csemiczky G, Hjelte L, Gottlieb C 1998 Female patients with cystic fibrosis suffer from reproductive endocrinological disorders despite good clinical status. Hum Reprod 13:2092-2097 (Pubitemid 28425093)
13. Galli-Tsinopoulou A, Moudiou T, Mamopoulos A, Karamouzis M, Nousia-Arvanitakis S 2006 Multifollicular ovaries in female adolescents with cystic fibrosis. Fertil Steril 85:1484-1487
14. Shawker TH, Hubbard VS, Reichert CM, Guerreiro de Matos OM 1983 Cystic ovaries in cystic fibrosis: an ultrasound and autopsy study. J Ultrasound Med 2:439-444 (Pubitemid 14239309)
15. Stead RJ, Hodson ME, Batten JC, Adams J, Jacobs HS 1987 Amenorrhoea in cystic fibrosis. Clin Endocrinol (Oxf) 26:187-195 (Pubitemid 17015705)
16. Broekmans FJ, Fauser BC 2006 Diagnostic criteria for polycystic ovarian syndrome. Endocrine 30:3-11 (Pubitemid 46020324)
17. Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, Koller BH 1992 An animal model for cystic fibrosis made by gene targeting. Science 257:1083-1088
18. Zeiher BG, Eichwald E, Zabner J, Smith JJ, Puga AP, McCray Jr PB, Capecchi MR, Welsh MJ, Thomas KR 1995 A mouse model for the δF508 allele of cystic fibrosis. J Clin Invest 96:2051-2064
19. Hodges CA, Palmert MR, Drumm ML 2008 Infertility in females with cystic fibrosis is multifactorial: evidence from mouse models. Endocrinology 149:2790-2797 (Pubitemid 351724529)
20. Xu WM, Shi QX, Chen WY, Zhou CX, Ni Y, Rowlands DK, Yi Liu G, Zhu H,MaZG, Wang XF, Chen ZH, Zhou SC, Dong HS, Zhang XH, Chung YW, Yuan YY, Yang WX, Chan HC 2007 Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility [see comment]. Proc Natl Acad Sci USA 104:9816-9821
21. Chan LN, Tsang LL, Rowlands DK, Rochelle LG, Boucher RC, Liu CQ, Chan HC 2002 Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract. J Membr Biol 185:165-176
22. Johannesson M, Gottlieb C, Hjelte L 1997 Delayed puberty in girls with cystic fibrosis despite good clinical status. Pediatrics 99:29-34 (Pubitemid 27136598)
23. Zhou G, Gao C, Xu P, Yao M, Xie J, Hu J 2008 Replication methodology of animal models of human disease. 1st ed. Shanghai: Shanghai Science and Technology Literature Press; 155-156
24. Bogovich K 1989 Induction of ovarian cysts in progesterone-synchronized immature rats: evidence that suppression of follicular aromatase activity is not a prerequisite for the induction of cystic follicles. Endocrinology 124:1646-1653 (Pubitemid 19105428)
25. Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF 2010 Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Hum Reprod 25:1441-1450
26. Amato MC, Verghi M, Nucera M, Galluzzo A, Giordano C 2011 Low estradiol-to-testosterone ratio is associated with oligo-anovulatory cycles and atherogenic lipidic pattern in women with polycystic ovary syndrome. Gynecol Endocrinol 27:579-586
27. Diamanti-Kandarakis E, Kandarakis H, Legro RS 2006 The role of genes and environment in the etiology of PCOS. Endocrine 30: 19-26 (Pubitemid 46020326)
28. Li Z, Huang H 2008 Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome. Med Hypotheses 70:638-642 (Pubitemid 351193031)
29. Hickey TE, Legro RS, Norman RJ 2006 Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome. J Clin Endocrinol Metab 91:2789-2791 (Pubitemid 44024652)
30. Norman RJ, Dewailly D, Legro RS, Hickey TE 2007 Polycystic ovary syndrome. Lancet 370:685-697 (Pubitemid 47285318)
31. Ito Y, Fisher CR, Conte FA, Grumbach MM, Simpson ER 1993 Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci USA 90:11673-11677 (Pubitemid 24008701)
32. Mullis PE, Yoshimura N, Kuhlmann B, Lippuner K, Jaeger P, Harada H 1997 Aromatase deficiency in a female who is compound heterozygote for two new point mutations in the P450arom gene: impact of estrogens on hypergonadotropic hypogonadism, multicystic ovaries, and bone densitometry in childhood. J Clin Endocrinol Metab 82:1739-1745 (Pubitemid 127495177)
33. Dale B, Menezo Y, Cohen J, DiMatteo L, Wilding M 1998 Intracellular pH regulation in the human oocyte. Hum Reprod 13:964-970 (Pubitemid 28239205)
34. Imoedemhe DA, Chan RC, Ramadan IA, Sigue AB 1993 Changes in follicular fluid gas and pH during carbon dioxide pneumoperitoneum for laparoscopic aspiration and their effect on human oocyte fertilizability. Fertil Steril 59:177-182 (Pubitemid 23027356)
35. Shalgi R, Kraicer PF, Soferman N 1972 Gases and electrolytes of human follicular fluid. J Reprod Fertil 28:335-340
36. Hunter RHF 2003 Physiology of the Graafian follicle and ovulation. Cambridge, UK: Cambridge University Press
37. Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL 2005 Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem 280:7997-8003 (Pubitemid 40349697)
38. Zaccolo M, Pozzan T 2002 Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295:1711-1715 (Pubitemid 34202906)
39. Mak JC, Chuang TT, Harris CA, Barnes PJ 2002 Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung. Eur J Pharmacol 436:165-172 (Pubitemid 34164696)