Synthesis and evaluation of sulfate conjugated metronidazole as a colon-specific prodrug of metronidazole

Journal of Drug Targeting

Volumn 20, Issue 3, 2012, Pages 255-263

  Kim, Hyunjeong ^a   Lee, Yonghyun ^a   Yoo, Hansun ^a   Kim, Jihye ^a   Kong, Hyesik ^b   Yoon, Jeong Hyun ^a   Jung, Yunjin ^a   Kim, Young Mi ^a  

^a Pusan National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Controlled drug delivery; Drug delivery; Drug targeting; Oral drug delivery

Indexed keywords

METRONIDAZOLE; NITROREDUCTASE; PRODRUG; SULFATE; SULFATE CONJUGATED METRONIDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CECUM; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL TRACT; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; SMALL INTESTINE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPROTOZOAL AGENTS; BIOTRANSFORMATION; CECUM; COLON; COLONIC DISEASES; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ESCHERICHIA COLI; GASTROINTESTINAL CONTENTS; INTESTINAL ABSORPTION; LIVER; MALE; METRONIDAZOLE; NITROREDUCTASES; PLASMA; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863234452     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2011.639024     Document Type: Article

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