Synthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil

Journal of Pharmaceutical Sciences

Volumn 90, Issue 11, 2001, Pages 1787-1794

  Lee Soo, Jeoung ^a   Jung, Yun Jin ^a   Kim, Young Mi ^a  

^a Pusan National University   (South Korea)

Author keywords

5 fluorouracil; Colon specific prodrug of 5 fluorouracil; N isonicotinyl 2 (5 fluorouracil 1 yl) D,L glycine; N nicotinyl 2 (5 fluorouracil l yl) D,L glycine

Indexed keywords

5 DIAZOURACIL; ENZYME INHIBITOR; FLUOROURACIL; N NICOTINYL 2 (5 FLUOROURACIL 1 YL)DEXTRO,LEVO GLYCINE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LARGE INTESTINE; MALE; NONHUMAN; PARTITION COEFFICIENT; RAT;

EID: 0035149489     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1128     Document Type: Article

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