Site-specific chemical modification of human serum albumin with polyethylene glycol prolongs half-life and improves intravascular retention in mice

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 3, 2012, Pages 280-288

  Zhao, Ting ^a   Cheng, Yan Na ^a   Tan, Hai Ning ^a   Liu, Jin Feng ^a   Xu, Huan Li ^a   Pang, Guang Li ^b   Wang, Feng Shan ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Taibang Biological Products Co Ltd   (China)

Author keywords

Biological half life; Capillary permeability; Human serum albumin; PEGylation

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HUMAN SERUM ALBUMIN; MACROGOL;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL PERMEABILITY; CAPILLARY LEAK SYNDROME; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG PURITY; DRUG RETENTION; DRUG STRUCTURE; FLUID THERAPY; HEMODILUTION; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; RAT; SEPSIS; SINGLE DRUG DOSE;

ACUTE LUNG INJURY; ANIMALS; BLOOD PRESSURE; CAPILLARY PERMEABILITY; HALF-LIFE; HEMATOCRIT; HUMANS; LIPOPOLYSACCHARIDES; MALE; MICE; PLASMA SUBSTITUTES; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SEPSIS; SERUM ALBUMIN; TISSUE DISTRIBUTION;

EID: 84863230231     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.35.280     Document Type: Article

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