Treatment with bisphenol A and methoxychlor results in the growth of human breast cancer cells and alteration of the expression of cell cycle-related genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway

International Journal of Molecular Medicine

Volumn 29, Issue 5, 2012, Pages 883-890

  Lee, Hye Rim ^a   Hwang, Kyung A ^a   Park, Min A H ^a   Yi, B O Rim ^a   Jeung, Eui Bae ^a   Choi, Kyung Chul ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Bisphenol A; Breast cancer; Cyclin D1; Estrogen receptor; Methoxychlor; p21

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; 4,4' ISOPROPYLIDENEDIPHENOL; CYCLIN D1; DIARYLPROPIONITRILE; ESTROGEN RECEPTOR; FULVESTRANT; METHOXYCHLOR; PROTEIN P21; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENICITY; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UPREGULATION;

BREAST NEOPLASMS; CARCINOGENS; CELL LINE, TUMOR; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ESTROGEN RECEPTOR ALPHA; ESTROGENS, NON-STEROIDAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, CDC; HUMANS; INSECTICIDES; METHOXYCHLOR; PHENOLS; SIGNAL TRANSDUCTION;

EID: 84863229365     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.903     Document Type: Article

References (38)

1. Nikaido Y, Danbara N, Tsujita-Kyutoku M, Yuri T, Uehara N and Tsubura A: Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice. In Vivo 19: 487-494, 2005. (Pubitemid 40568125)
2. Migliarini B, Piccinetti CC, Martella A, Maradonna F, Gioacchini G and Carnevali O: Perspectives on endocrine disruptor effects on metabolic sensors. Gen Comp Endocrinol 170: 416-423, 2011.
3. Choi KC and Jeung EB: The biomarker and endocrine disruptors in mammals. J Reprod Dev 49: 337-345, 2003.
4. Dang VH, Nguyen TH, Lee GS, Choi KC and Jeung EB: In vitro exposure to xenoestrogens induces growth hormone transcription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells. Steroids 74: 707-714, 2009.
5. Bondar G, Kuo J, Hamid N and Micevych P: Estradiol-induced estrogen receptor-alpha trafficking. J Neurosci 29: 15323-15330, 2009.
6. Pacifici R: Estrogen deficiency, T cells and bone loss. Cell Immunol 252: 68-80, 2008.
7. Li J and McMurray RW: Effects of estrogen receptor subtype-selective agonists on immune functions in ovariectomized mice. Int Immunopharmacol 6: 1413-1423, 2006. (Pubitemid 44038682)
8. Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC and Lam EW: ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. J Biol Chem 280: 3185-3196, 2005. (Pubitemid 40223780)
9. Vandenberg LN, Hauser R, Marcus M, Olea N and Welshons WV: Human exposure to bisphenol A (BPA). Reprod Toxicol 24: 139-177, 2007. (Pubitemid 47385100)
10. Choi SM, Yoo SD and Lee BM: Toxicological characteristics of endocrine-disrupting chemicals: developmental toxicity, carcinogenicity, and mutagenicity. J Toxicol Environ Health B Crit Rev 7: 1-24, 2004. (Pubitemid 38117512)
11. Bonefeld-Jorgensen EC, Long M, Hofmeister MV and Vinggaard AM: Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octyl-phenol in vitro: new data and a brief review. Environ Health Perspect 115 (Suppl 1): 69-76, 2007.
12. Mielke H and Gundert-Remy U: Bisphenol A levels in blood depend on age and exposure. Toxicol Lett 190: 32-40, 2009.
13. Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM and Lanphear BP: Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 117: 1945-1952, 2009.
14. Wadia PR, Vandenberg LN, Schaeberle CM, Rubin BS, Sonnenschein C and Soto AM: Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains. Environ Health Perspect 115: 592-598, 2007. (Pubitemid 46585532)
15. Izzotti A, Kanitz S, D'Agostini F, Camoirano A and De Flora S: Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice. Mutat Res 679: 28-32, 2009.
16. Dang VH, Choi KC, Hyun SH and Jeung EB: Analysis of gene expression profiles in the offspring of rats following maternal exposure to xenoestrogens. Reprod Toxicol 23: 42-54, 2007. (Pubitemid 46027539)
17. Tillett T: Bisphenol A, chapter 2: new data shed light on exposure, potential bioaccumulation. Environ Health Perspect 117: A210, 2009.
18. Hunt PA, Susiarjo M, Rubio C and Hassold TJ: The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction. Biol Reprod 81: 807-813, 2009.
19. Keri RA, Ho SM, Hunt PA, Knudsen KE, Soto AM and Prins GS: An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod Toxicol 24: 240-252, 2007. (Pubitemid 47393608)
20. Suzuki M, Lee HC, Chiba S, Yonezawa T and Nishihara M: Effects of methoxychlor exposure during perinatal period on reproductive function after maturation in rats. J Reprod Dev 50: 455-461, 2004. (Pubitemid 40631795)
21. Armenti AE, Zama AM, Passantino L and Uzumcu M: Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats. Toxicol Appl Pharmacol 233: 286-296, 2008. (Pubitemid 50306578)
22. Amstislavsky SY, Amstislavskaya TG, Amstislavsky VS, Tibeikina MA, Osipov KV and Eroschenko VP: Reproductive abnormalities in adult male mice following preimplantation exposures to estradiol or pesticide methoxychlor. Reprod Toxicol 21: 154-159, 2006. (Pubitemid 43087689)
23. Park SH, Kim KY, An BS, Choi JH, Jeung EB, Leung PC and Choi KC: Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38. J Reprod Dev 55: 23-29, 2009.
24. Yi BR, Kang NH, Hwang KA, Kim SU, Jeung EB and Choi KC: Antitumor therapeutic effects of cytosine deaminase and interferon-beta against endometrial cancer cells using genetically engineered stem cells in vitro. Anticancer Res 31: 2853-2861, 2011.
25. Felty Q, Singh KP and Roy D: Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling. Oncogene 24: 4883-4893, 2005. (Pubitemid 41129093)
26. Foster JS, Henley DC, Ahamed S and Wimalasena J: Estrogens and cell-cycle regulation in breast cancer. Trends Endocrinol Metab 12: 320-327, 2001. (Pubitemid 33714224)
27. Yano M, Naito Z, Yokoyama M, Shiraki Y, Ishiwata T, Inokuchi M and Asano G: Expression of hsp90 and cyclin D1 in human breast cancer. Cancer Lett 137: 45-51, 1999. (Pubitemid 29179495)
28. Aaltonen K, Amini RM, Landberg G, Eerola H, Aittomaki K, Heikkila P, Nevanlinna H and Blomqvist C: Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer. Breast Cancer Res Treat 113: 75-82, 2009.
29. Cheng WL, Lin TY, Tseng YH, Chu FH, Chueh PJ, Kuo YH and Wang SY: Inhibitory effect of human breast cancer cell proliferation via p21-mediated G1 cell cycle arrest by araliadiol isolated from Aralia cordata Thunb. Planta Med 77: 164-168, 2011.
30. Wang X, Gao P, Long M, Lin F, Wei JX, Ren JH, Yan L, He T, Han Y and Zhang HZ: Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol 28: 1225-1254, 2011.
31. Mandal S and Davie JR: Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells. J Cell Physiol 224: 28-32, 2010.
32. Hong EJ, Choi KC and Jeung EB: Induction of calbindin-D9k messenger RNA and protein by maternal exposure to alkylphenols during late pregnancy in maternal and neonatal uteri of rats. Biol Reprod 71: 669-675, 2004.
33. Rivas A, Lacroix M, Olea-Serrano F, Laios I, Leclercq G and Olea N: Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 82: 45-53, 2002. (Pubitemid 35341399)
34. Ho SM, Tang WY, Belmonte de Frausto J and Prins GS: Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66: 5624-5632, 2006.
35. Shin JH, Moon HJ, Kang IH, Kim TS, Lee SJ, Oh JY, Lee YJ, Hong EJ, Jeung EB and Han SY: Calbindin-D9k mRNA expression in the rat uterus following exposure to methoxychlor: a comparison of oral and subcutaneous exposure. J Reprod Dev 53: 179-188, 2007. (Pubitemid 46743542)
36. Ottinger MA, Wu JM, Hazelton JL, Abdelnabi MA, Thompson N, Quinn ML Jr, Donoghue D, Schenck F, Ruscio M, Beavers J and Jaber M: Assessing the consequences of the pesticide methoxychlor: neuroendocrine and behavioral measures as indicators of biological impact of an estrogenic environmental chemical. Brain Res Bull 65: 199-209, 2005. (Pubitemid 40461964)
37. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, Sun J, Katzenellenbogen BS and Katzenellenbogen JA: Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem 43: 4934-4947, 2000. (Pubitemid 32040974)
38. Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS and Katzenellenbogen JA: Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44: 4230-4251, 2001. (Pubitemid 33095330)