The antineoplastic antibiotic taurolidine promotes lung and liver metastasis in two syngeneic osteosarcoma mouse models and exhibits severe liver toxicity

International Journal of Cancer

Volumn 131, Issue 5, 2012, Pages

  Arlt, Matthias J E ^a   Walters, Denise K ^a   Banke, Ingo J ^a   Steinmann, Patrick ^a   Puskas, Gabor J ^a   Bertz, Josefine ^a   Rentsch, Katharina M ^b   Ehrensperger, Felix ^c   Born, Walter ^a   Fuchs, Bruno ^a  

^a BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cytotoxicity; Metastasis; Osteosarcoma; Side effects; Taurolidine

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTAMATE DEHYDROGENASE; TAUROLIDINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; DRUG TREATMENT FAILURE; FEMALE; LIVER CELL; LIVER METASTASIS; LIVER TOXICITY; LUNG METASTASIS; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; TOXICITY TESTING; ULTRASTRUCTURE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BONE NEOPLASMS; DRUG-INDUCED LIVER INJURY; FEMALE; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; OSTEOSARCOMA; TAURINE; THIADIAZINES; TUMOR CELLS, CULTURED;

EID: 84863229045     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27378     Document Type: Article

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