Breast cancer risk and 6q22.33: Combined results from breast cancer association consortium and consortium of investigators on modifiers of brca1/2

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Kirchhoff, Tomas ^a,ae   Offit, Kenneth ^a   Gaudet, Mia M ^a,af   Pharoah, Paul D P ^b   Easton, Douglas F ^b   Antoniou, Antonis C ^b   Mcguffog, Lesley ^b   Humphreys, Manjeet K ^b   Dunning, Alison M ^b   Bojesen, Stig E ^c   Nordestgaard, Børge G ^c   Flyger, Henrik ^c,ag   Kang, Daehee ^d,ah   Yoo, Keun Young ^d,ah   Noh, Dong Young ^d,ah   Ahn, Sei Hyun ^d,ah   Dork, Thilo ^e   Schürmann, Peter ^e   Karstens, Johann H ^e   Hillemanns, Peter ^e   Couch, Fergus J ^f   Olson, Janet ^f   Vachon, Celine ^f   Wang, Xianshu ^f   Cox, Angela ^g   Brock, Ian ^g   Elliott, Graeme ^g   Reed, Malcolm W R ^g   Burwinkel, Barbara ^h   Meindl, Alfons ^h,ai   Brauch, Hiltrud ⁱ   Justenhoven, Christina ⁱ   Hamann, Ute ^h,i   Ko, Yon Dschun ^i,aj   Fischer, Hans Peter ^i,ak   Brüning, Thomas ^i,al   Pesch, Beate ^i,al   Harth, Volker ^i,al   Rabstein, Sylvia ^i,al   Broeks, Annegien ^j   Schmidt, Marjanka K ^j   Van 't Veer, Laura J ^j   Braaf, Linde M ^j   Johnson, Nichola ^k   Fletcher, Olivia ^k   Gibson, Lorna ^k,am   Peto, Julian ^k,am   Turnbull, Clare ^k   Seal, Sheila ^k   Renwick, Anthony ^k   Rahman, Nazneen ^k   Wu, Pei Ei ^l,an   Yu, Jyh Cherng ^l,ao   Hsiung, Chia Ni ^l   Shen, Chen Yang ^l   Southey, Melissa C ^m,u   Hopper, John L ^m   Hammet, Fleur ^m   van Dorpe, Thijs ⁿ   Dieudonne, Anne Sophie ⁿ   Hatse, Sigrid ⁿ   Lambrechts, Diether ^n,ap   Andrulis, Irene L ^o,aq,ar   Bogdanova, Natalia ^p   Antonenkova, Natalia ^p   Rogov, Juri I ^p   Prokofieva, Daria ^q   Bermisheva, Marina ^q   Khusnutdinova, Elza ^q   van Asperen, Christi J ^r   Tollenaar, Robert A E M ^r   Hooning, Maartje J ^r   Devilee, Peter ^r   Margolin, Sara ^s,as   Lindblom, Annika ^s   Milne, Roger L ^t   Arias, José Ignacio ^t,au   Pilar Zamora, M ^t,av   Benítez, Javier ^t,at   Severi, Gianluca ^m,u   Baglietto, Laura ^m,u   Giles, Graham G ^m,u   Chenevix Trench, Georgia ^v,aw   Spurdle, Amanda B ^v,aw   Beesley, Jonathan ^v,aw   Chen, Xiaoqing ^v,aw   Holland, Helene ^v,aw   Healey, Sue ^v,aw   Wang Gohrke, Shan ^h,ax   Chang Claude, Jenny ^h   Mannermaa, Arto ^w   Kosma, Veli Matti ^w   Kauppinen, Jaana ^w   Kataja, Vesa ^w,ay   Agnarsson, Bjarni A ^x   Caligo, Maria A ^y   Godwin, Andrew K ^z   Nevanlinna, Heli ^aa   Heikkinen, Tuomas ^aa   Fredericksen, Zachary ^f   Lindor, Noralane ^f   Nathanson, Katherine L ^ab   Domchek, Susan M ^ab   Loman, Niklas ^ac   Karlsson, Per ^ac,az   Askmalm, Marie Stenmark ^ac,ba   Melin, Beatrice ^ac,bb   Von Wachenfeldt, Anna ^ac,bc   Hogervorst, Frans B L ^j   Verheus, Martijn ^j   Rookus, Matti A ^j   Seynaeve, Caroline ^j,bd   Oldenburg, Rogier A ^j,bd   Ligtenberg, Marjolijn J ^j,be   Ausems, Margreet G E M ^j,bf   Aalfs, Cora M ^j,bg   Gille, Hans J P ^j,bh   Wijnen, Juul T ^j,r   Gómez García, Encarna B ^j,bi   Peock, Susan ^b   Cook, Margaret ^b   Oliver, Clare T ^b   Frost, Debra ^b   Luccarini, Craig ^b   Pichert, Gabriella ^b,bl   Davidson, Rosemarie ^b,bm   Chu, Carol ^b,bn   Eccles, Diana ^b,bo   Ong, Kai Ren ^b,bp   Cook, Jackie ^b,bq   Douglas, Fiona ^b,br   Hodgson, Shirley ^b,bs   Gareth Evans, D ^b,bj   Eeles, Rosalind ^b,bk   Gold, Bert ^ad   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Mental Health Center Glostrup   (Denmark)

^d Seoul National University College of Medicine   (South Korea)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f MAYO CLINIC   (United States)

^g UNIVERSITY OF SHEFFIELD   (United Kingdom)

^h GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

ⁱ DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^j NETHERLANDS CANCER INSTITUTE   (Netherlands)

^k INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^l INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^m UNIVERSITY OF MELBOURNE   (Australia)

ⁿ UNIVERSITY OF LEUVEN   (Belgium)

^o CANCER CARE ONTARIO   (Canada)

^p Research Institute of Oncology and Medical Radiology of the Ministry of Health of the Byelorussian SSR   (Belarus)

^q INSTITUTE OF BIOCHEMISTRY AND GENETICS   (Russian Federation)

^r LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^s Karolinska Breast Cancer Study (KARBAC)   (Sweden)

^t Structural Biology and Biocomputing Programme   (Spain)

^u CANCER EPIDEMIOLOGY CENTRE   (Australia)

^v QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^w KUOPIO UNIVERSITY HOSPITAL   (Finland)

^x LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^y UNIVERSITY OF PISA   (Italy)

^z FOX CHASE CANCER CENTER   (United States)

^aa HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^ab UNIVERSITY OF PENNSYLVANIA   (United States)

^ac LUND UNIVERSITY HOSPITAL   (Sweden)

^ad NATIONAL CANCER INSTITUTE   (United States)

^ae NEW YORK UNIVERSITY   (United States)

^af AMERICAN CANCER SOCIETY   (United States)

^ag GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^ah University of Ulsan College of Medicine   (South Korea)

^ai TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^aj Johanniter Krankenhaus   (Germany)

^ak UNIVERSITY OF BONN   (Germany)

^al INSTITUT DER RUHR UNIVERSITÄT BOCHUM IPA   (Germany)

^am LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^an ACADEMIA SINICA   (Taiwan)

^ao TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^ap Vesalius Research Center   (Belgium)

^aq MOUNT SINAI HOSPITAL   (Canada)

^ar UNIVERSITY OF TORONTO   (Canada)

^as KAROLINSKA INSTITUTE   (Sweden)

^at CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^au Monte Naranco Hospital   (Spain)

^av HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^aw PETER MACCALLUM CANCER CENTRE   (Australia)

^ax UNIVERSITY OF ULM   (Germany)

^ay VAASA CENTRAL HOSPITAL   (Finland)

^az SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^ba LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^bb UMEÅ UNIVERSITY   (Sweden)

^bc KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^bd ERASMUS MEDICAL CENTER   (Netherlands)

^be RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^bf UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^bg ACADEMIC MEDICAL CENTER   (Netherlands)

^bh VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^bi MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^bj UNIVERSITY OF MANCHESTER   (United Kingdom)

^bk INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^bl GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^bm ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^bn Yorkshire Regional Genetics Service   (United Kingdom)

^bo PRINCESS ANNE HOSPITAL   (United Kingdom)

^bp BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^bq SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^br NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^bs ST GEORGE S HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CHROMOSOME 6Q; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; REPLICATION STUDY; TUMOR SUPPRESSOR GENE;

EID: 84863215020     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035706     Document Type: Article

References (24)

1. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, et al. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087-1093.
2. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, et al. (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39: 870-874.
3. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, et al. (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39: 865-869.
4. Zheng W, Long J, Gao YT, Li C, Zheng Y, et al. (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41: 324-328.
5. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, et al. (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41: 585-590.
6. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, et al. (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41: 579-584.
7. Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, et al. (2008) Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A 105: 4340-4345.
8. Kirchhoff T, Chen ZQ, Gold B, Pal P, Gaudet MM, et al. (2009) The 6q22.33 locus and breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 18: 2468-2475.
9. Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, et al. (2009) Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet 18: 1131-1139.
10. Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL, et al. (2009) Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 18: 1610-1616.
11. Milne RL, Benitez J, Nevanlinna H, Heikkinen T, Aittomaki K, et al. (2009) Risk of estrogen receptor-positive and-negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst 101: 1012-1018.
12. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
13. Higgins JP, Thompson SG, Deeks JJ, Altman DG, (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560.
14. Antoniou AC, Goldgar DE, Andrieu N, Chang-Claude J, Brohet R, et al. (2005) A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol 29: 1-11.
15. Dai J, Hu Z, Jiang Y, Shen H, Dong J, et al. (2012) Breast cancer risk assessment with five independent genetic variants and two risk factors in chinese women. Breast Cancer Res 14: R17.
16. Hemminki K, Muller-Myhsok B, Lichtner P, Engel C, Chen B, et al. (2010) Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients. Int J Cancer 126: 2858-2862.
17. Lin PI, Vance JM, Pericak-Vance MA, Martin ER, (2007) No gene is an island: the flip-flop phenomenon. Am J Hum Genet 80: 531-538.
18. Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N, (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96: 434-442.
19. Broeks A, Schmidt MK, Sherman ME, Couch FJ, Hopper JL, et al. (2011) Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet 20: 3289-3303.
20. Ma Y, Fan S, Hu C, Meng Q, Fuqua SA, et al. (2010) BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha. Mol Endocrinol 24: 76-90.
21. Dizin E, Irminger-Finger I, (2010) Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1. Int J Biochem Cell Biol 42(5): 693-700.
22. Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, et al. (2011) RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol 13: 623-629.
23. Wang Z, Michaud GA, Cheng Z, Zhang Y, Hinds TR, et al. (2012) Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev.
24. Callow MG, Tran H, Phu L, Lau T, Lee J, et al. (2011) Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. PLoS One 6: e22595.