Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4258-4270

  Takács, Daniella ^a   Nagy, Ildikó ^a,b   Bombicz, Petra ^a   Egyed, Orsolya ^a   Jemnitz, Katalin ^a   Riedl, Zsuzsanna ^a   Molnár, József ^c   Amaral, Leonard ^d   Hajós, György ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b Bioblocks Magyarország Kft ^*  (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

Catalytic hydrogenation; Dieneamine; Hydroboration; Multidrug resistance; P gp inhibition

Indexed keywords

10 [4 (2 PHENYL 2H TETRAZOL 5 YL)BUTYL] 10H PHENOTHIAZINE; 10 [4 (2 PHENYL 2H TETRAZOL 5 YL)BUTYL] 2 (TRIFLUOROMETHYL) 10H PHENOTHIAZINE; 10 [4 [2 (4 BROMOPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 10 [4 [2 (4 BROMOPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 2 (TRIFLUOROMETHYL) 10H PHENOTHIAZINE; 10 [4 [2 (4 BROMOPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 2 CHLORO 10H PHENOTHIAZINE; 10 [4 [2 (4 CHLOROPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 10 [4 [2 (4 FLUOROPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 10 [4 [2 (4 FLUOROPHENYL) 2H TETRAZOL 5 YL]BUTYL] 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 2 (2 METHYL 1,3 DIOXOLAN 2 YL) 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 2 (TRIFLUOROMETHYL) 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTYL] 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTYL] 2 (2 METHYL 1,3 DIOXOLAN 2 YL) 10H PHENOTHIAZINE; 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTYL] 2 (TRIFLUOROMETHYL) 10H PHENOTHIAZINE; 10 [4 [2 (4 TOLYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 10 [4 [2 (4 TOLYL) 2H TETRAZOL 5 YL]BUTYL] 10H PHENOTHIAZINE; 2 CHLORO 10 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 10H PHENOTHIAZINE; 9 [4 (2 PHENYL 2H TETRAZOL 5 YL)BUTYL] 9H CARBAZOLE; 9 [4 [2 (4 BROMOPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 9H CARBAZOLE; 9 [4 [2 (4 CHLOROPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 9H CARBAZOLE; 9 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 9H CARBAZOLE; 9 [4 [2 (4 METHOXYPHENYL) 2H TETRAZOL 5 YL]BUTYL] 9H CARBAZOLE; 9 [4 [2 (4 TOLYL) 2H TETRAZOL 5 YL]BUTA 1,3 DIEN 1 YL] 9H CARBAZOLE; DIENEAMINE DERIVATIVE; GLYCOPROTEIN P; HYDROXYALKYLPHENOTHIAZINE DERIVATIVE; PHENOTHIAZINE DERIVATIVE; TETRAZOLYLDIENYL PHENOTHIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; HYDROBORATION; HYDROGENATION; MALE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILICITY; OXIDATION; RAT;

AMINES; ANIMALS; BORANES; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE; HEPATOCYTES; MALE; MOLECULAR CONFORMATION; P-GLYCOPROTEIN; PHENOTHIAZINES; PYRIMIDINES; RATS; RATS, WISTAR;

EID: 84863197504     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.065     Document Type: Article

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