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Volumn 26, Issue 2, 2012, Pages 230-235

The antinociceptive effect of intrathecal tramadol in rats: The role of alpha 2-adrenoceptors in the spinal cord

Author keywords

2 Adrenoceptor; Affinity; Antinociception; Spinal cord; Tramadol; Yohimbine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; FORMALDEHYDE; TRAMADOL; YOHIMBINE;

EID: 84863196254     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-011-1267-4     Document Type: Article
Times cited : (11)

References (23)
  • 1
    • 28244479836 scopus 로고    scopus 로고
    • Recent evidences in the pharmacological mechanisms of the tramadol
    • Mimami K. Recent evidences in the pharmacological mechanisms of the tramadol. Masui. 2005;54:1224-33. (Pubitemid 41704032)
    • (2005) Japanese Journal of Anesthesiology , vol.54 , Issue.11 , pp. 1224-1233
    • Mimami, K.1
  • 2
    • 0026512239 scopus 로고
    • Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioid analgesic
    • Raffa RB, Friderichs E, Reimann W, Shank RP. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioid analgesic. J Pharmacol Exp Ther. 1992;260:275-85.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 275-85
    • Raffa, R.B.1    Friderichs, E.2    Reimann, W.3    Shank, R.P.4
  • 3
    • 0026564002 scopus 로고
    • Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat
    • Kayser V, Besson JM, Guilbaud G. Evidence for a noradrenergic component in the antinociceptive effect of the analgesic agent tramadol in an animal model of clinical pain, the arthritic rat. Eur J Pharmacol. 1992;224:83-8.
    • (1992) Eur J Pharmacol , vol.224 , pp. 83-8
    • Kayser, V.1    Besson, J.M.2    Guilbaud, G.3
  • 4
    • 0027511794 scopus 로고
    • Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro
    • Driessen B, Reimann W, Giertz H. Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro. Br J Pharmacol. 1993;108:806-10.
    • (1993) Br J Pharmacol , vol.108 , pp. 806-10
    • Driessen, B.1    Reimann, W.2    Giertz, H.3
  • 5
    • 0030882035 scopus 로고    scopus 로고
    • Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus
    • Bamigbade TA, Davidson C, Langford RM, Stamford JA. Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus. Br J Anaesth. 1997;79:352-7.
    • (1997) Br J Anaesth , vol.79 , pp. 352-7
    • Bamigbade, T.A.1    Davidson, C.2    Langford, R.M.3    Stamford, J.A.4
  • 6
    • 26444500187 scopus 로고    scopus 로고
    • A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children
    • DOI 10.1093/bja/aei214
    • Demiraran Y, Kocaman B, Akman RY. A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children. Br J Anaesth. 2005;95:510-3. (Pubitemid 41418747)
    • (2005) British Journal of Anaesthesia , vol.95 , Issue.4 , pp. 510-513
    • Demiraran, Y.1    Kocaman, B.2    Akman, R.Y.3
  • 7
    • 0033759980 scopus 로고    scopus 로고
    • Tramadol or ketamine for caudal analgesia?
    • Zenz M, Zenner D. Tramadol or ketamine for caudal analgesia? Br J Anaesth. 2000;85:805-7.
    • (2000) Br J Anaesth , vol.85 , pp. 805-7
    • Zenz, M.1    Zenner, D.2
  • 8
    • 0141997015 scopus 로고    scopus 로고
    • Effect of intrathecal tramadol administration on postoperative pain after transurethral resection of prostate
    • DOI 10.1093/bja/aeg213
    • Alhashemi JA, Kaki AM. Effect of intrathecal tramadol administration on postoperative pain after transurethral resection of prostate. Br J Anaesth. 2003;91:536-40. (Pubitemid 37258598)
    • (2003) British Journal of Anaesthesia , vol.91 , Issue.4 , pp. 536-540
    • Alhashemi, J.A.1    Kaki, A.M.2
  • 10
    • 0033952074 scopus 로고    scopus 로고
    • 2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain
    • Asano T, Dohi S, Ohta S, Shimonaka H. Antinociception by epidural and systemic a2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg. 2000; 90:400-7. (Pubitemid 30078023)
    • (2000) Anesthesia and Analgesia , vol.90 , Issue.2 , pp. 400-407
    • Asano, T.1    Dohi, S.2    Ohta, S.3    Shimonaka, H.4    Iida, H.5
  • 11
    • 22544472156 scopus 로고    scopus 로고
    • Synergic antinociceptive interaction between tramadol and gabapentin after local, spinal and systemic administration
    • DOI 10.1159/000085700
    • Granados-Soto V, Argüelles CF. Synergic antinociceptive interaction between tramadol and gabapentin after local, spinal and systemic administration. Pharmacology. 2005;74:200-8. (Pubitemid 41022582)
    • (2005) Pharmacology , vol.74 , Issue.4 , pp. 200-208
    • Granados-Soto, V.1    Arguelles, C.F.2
  • 12
    • 0017643233 scopus 로고
    • The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
    • DOI 10.1016/0304-3959(77)90130-0
    • Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 1977;4:161-74. (Pubitemid 8234766)
    • (1977) Pain , vol.4 , Issue.2 , pp. 161-174
    • Dubuisson, D.1    Dennis, S.G.2
  • 13
    • 0028833853 scopus 로고
    • The formalin test: Scoring properties of the first and second phases of the pain response in rats
    • Abbott F, Franklin K, Westbrook R. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 1995;60:91-102.
    • (1995) Pain , vol.60 , pp. 91-102
    • Abbott, F.1    Franklin, K.2    Westbrook, R.3
  • 14
    • 0019827134 scopus 로고
    • Simple method for rapid removal of rat spinal cord
    • Yaksh TL, Harry GL. Simple method for rapid removal of rat spinal cord. Brain Res Bull. 1981;6:449-50. (Pubitemid 11088089)
    • (1981) Brain Research Bulletin , vol.6 , Issue.5 , pp. 449-450
    • Yaksh, T.L.1    Harty, G.J.2
  • 15
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction
    • Cheng YC, Prusoff WH. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50% inhibition (I50) of an enzymatic reaction. Biochem Pharmacol. 1973;22:3099-102.
    • (1973) Biochem Pharmacol , vol.22 , pp. 3099-102
    • Cheng, Y.C.1    Prusoff, W.H.2
  • 16
    • 0014127723 scopus 로고
    • A graphic method for the determination and presentation of binding parameters in a complex system
    • Rosenthal HE. A graphic method for the determination and presentation of binding parameters in a complex system. Anal Biochem. 1967;20:525-32.
    • (1967) Anal Biochem , vol.20 , pp. 525-32
    • Rosenthal, H.E.1
  • 17
    • 0022646185 scopus 로고
    • Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats
    • Bernatzky G, Jurna I. Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats. Eur J Pharmacol. 1986;120:75-80. (Pubitemid 16134681)
    • (1986) European Journal of Pharmacology , vol.120 , Issue.1 , pp. 75-80
    • Bernatzky, G.1    Jurna, I.2
  • 18
    • 77649175141 scopus 로고    scopus 로고
    • Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-desmethyltramadol, via activation of descending serotonergic pathways
    • Yanarates O, Dogrul A, Yildirim V, Sahin A, Sizlan A, Seyrek M, Akgü l O, Kozak O, Kurt E, Aypar U. Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-desmethyltramadol, via activation of descending serotonergic pathways. Anesthesiology. 2010;112:696-710.
    • (2010) Anesthesiology , vol.112 , pp. 696-710
    • Yanarates, O.1    Dogrul, A.2    Yildirim, V.3    Sahin, A.4    Sizlan, A.5    Seyrek, M.6    Akgü, L.O.7    Kozak, O.8    Kurt, E.9    Aypar, U.10
  • 19
    • 0028308235 scopus 로고
    • Inhibition of spinal noradrenaline uptake in rats by the centrally acting analgesic tramadol
    • DOI 10.1016/0006-2952(94)90267-4
    • Reimann W, Hennies HH. Inhibition of spinal noradrenaline uptake in rats by the centrally acting analgesic tramadol. Biochem Pharmacol. 1994;47:2289-93. (Pubitemid 24216407)
    • (1994) Biochemical Pharmacology , vol.47 , Issue.12 , pp. 2289-2293
    • Reimann, W.1    Hennies, H.-H.2
  • 20
    • 0011821810 scopus 로고
    • Noradrenergic receptors in the dorsal horn of the spinal cord
    • Besson JM, Guilbaud G, editors. Amsterdam: Elsevier
    • Headley PM. Noradrenergic receptors in the dorsal horn of the spinal cord. In: Besson JM, Guilbaud G, editors. In towards the use of noradrenergic agonists for the treatment of pain. Amsterdam: Elsevier; 1992. p. 169-81.
    • (1992) Towards the Use of Noradrenergic Agonists for the Treatment of Pain , pp. 169-81
    • Headley, P.M.1
  • 21
    • 0025884066 scopus 로고
    • Descending noradrenergic influences on pain
    • Jones SL. Descending noradrenergic influences on pain. Prog Brain Res. 1991;88:381-94.
    • (1991) Prog Brain Res , vol.88 , pp. 381-94
    • Jones, S.L.1
  • 22
    • 0002238746 scopus 로고
    • Behavioural pharmacology of noradrenergic descending system
    • Besson JM, Guilbaud G, editors. Amsterdam: Elsevier
    • Proudfit HK. Behavioural pharmacology of noradrenergic descending system. In: Besson JM, Guilbaud G, editors. In towards the use of noradrenergic agonists for the treatment of pain. Amsterdam: Elsevier; 1992. p. 119-37.
    • (1992) Towards the Use of Noradrenergic Agonists for the Treatment of Pain , pp. 119-37
    • Proudfit, H.K.1
  • 23
    • 22744459156 scopus 로고    scopus 로고
    • Tramadol produces outward currents by activating μ-opioid receptors in adult rat substantia gelatinosa neurones
    • DOI 10.1038/sj.bjp.0706225
    • Koga A, Fujita T, Totoki T, Kumamoto E. Tramadol produces outward currents by activating mu-opioid receptors in adult rat substantia gelatinosa neurones. Br J Pharmacol. 2005;145:602-7. (Pubitemid 41032632)
    • (2005) British Journal of Pharmacology , vol.145 , Issue.5 , pp. 602-607
    • Koga, A.1    Fujita, T.2    Totoki, T.3    Kumamoto, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.