Waon therapy upregulates Hsp90 and leads to angiogenesis through the Akt-endothelial nitric oxide synthase pathway in mouse hindlimb ischemia

Circulation Journal

Volumn 76, Issue 7, 2012, Pages 1712-1721

  Miyauchi, Takahiro ^a   Miyata, Masaaki ^a   Ikeda, Yoshiyuki ^a   Akasaki, Yuichi ^a   Hamada, Narisato ^a   Shirasawa, Takahiro ^a   Furusho, Yuko ^a   Tei, Chuwa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; eNOS; Hsp90; Waon therapy

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALVESPIMYCIN; ANGIOPOIETIN RECEPTOR; CD31 ANTIGEN; CELL MARKER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 32; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; NG 2 PROTEIN; NITRATE; NITRITE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CAPILLARY DENSITY; CONTROLLED STUDY; CORE TEMPERATURE; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; LASER DOPPLER FLOWMETRY; LEG ISCHEMIA; MALE; MOUSE; NONHUMAN; PHYSICAL MEDICINE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THERMAL THERAPY; ULTRAFILTRATION; UPREGULATION; WAON THERAPY; WESTERN BLOTTING;

ANGIOGENIC PROTEINS; ANIMALS; APOLIPOPROTEINS E; ARTERIES; BENZOQUINONES; BLOOD FLOW VELOCITY; CAPILLARIES; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HINDLIMB; HSP90 HEAT-SHOCK PROTEINS; HYPERTHERMIA, INDUCED; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LACTAMS, MACROCYCLIC; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION;

EID: 84863194841     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-11-0915     Document Type: Article

References (37)

1. Tei C, Horikiri Y, Park JC, Jeong JW, Chang KS, Toyama Y, et al. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation 1995; 91: 2582-2590.
2. Miyata M, Tei C. Waon therapy for cardiovascular disease: Innovative therapy for the 21st century. Circ J 2010; 74: 617-621.
3. Tei C, Tanaka N. Thermal vasodilation as a treatment of congestive heart failure: A novel approach. J Cardiol 1996; 27: 29-30.
4. Kihara T, Biro S, Imamura M, Yoshifuku S, Takasaki K, Ikeda Y, et al. Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol 2002; 39: 754-759.
5. Kihara T, Biro S, Ikeda Y, Fukudome T, Shinsato T, Masuda A, et al. Effects of repeated sauna treatment on ventricular arrhythmias in patients with chronic heart failure. Circ J 2004; 68: 1146-1151.
6. Miyata M, Kihara T, Kubozono T, Ikeda Y, Shinsato T, Izumi T, et al. Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study. J Cardiol 2008; 52: 79-85.
7. Basford JR, Oh JK, Allison TG, Sheffield CG, Manahan BG, Hodge DO, et al. Safety, acceptance, and physiologic effects of sauna bathing in people with chronic heart failure: A pilot report. Arch Phys Med Rehabil 2009; 90: 173-177.
8. Kuwahata S, Miyata M, Fujita S, Kubozono T, Shinsato T, Ikeda Y, et al. Improvement of autonomic nervous activity by Waon therapy in patients with chronic heart failure. J Cardiol 2011; 57: 100-106.
9. Fujita S, Ikeda Y, Miyata M, Shinsato T, Kubozono T, Kuwahata S, et al. Effect of Waon therapy on oxidative stress in chronic heart failure. Circ J 2011; 75: 348-356.
10. Kihara T, Miyata M, Fukudome T, Ikeda Y, Shinsato T, Kubozono T, et al. Waon therapy improves the prognosis of patients with chronic heart failure. J Cardiol 2009; 53: 214-218.
11. Tei C, Shinsato T, Miyata M, Kihara T, Hamasaki S. Waon therapy improves peripheral arterial disease. J Am Coll Cardiol 2007; 50: 2169-2171.
12. Tei C, Shinsato T, Kihara T, Miyata M. Successful thermal therapy for end-stage peripheral artery disease. J Cardiol 2006; 47: 163-164.
13. Shinsato T, Miyata M, Kubozono T, Ikeda Y, Fujita S, Kuwahata S, et al. Waon therapy mobilizes CD34+ cells and improves peripheral arterial disease. J Cardiol 2010; 56: 361-366.
14. Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 2006; 70: 463-470.
15. Pratt WB. The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. Annu Rev Pharmacol Toxicol 1997; 37: 297-326.
16. Sato S, Fujita N, Tsuruo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 2000; 97: 10832-10837.
17. Brouet A, Sonveaux P, Dessy C, Balligand JL, Feron O. Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem 2001; 276: 32663-32669.
18. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142.
19. Cooke JP, Losordo DW. Nitric oxide and angiogenesis. Circulation 2002; 105: 2133-2135.
20. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370-1376.
21. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol 1998; 152: 1667-1679.
22. Ikeda Y, Biro S, Kamogawa Y, Yoshifuku S, Eto H, Orihara K, et al. Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters. Circ J 2005; 69: 722-729.
23. Lang SA, Moser C, Gaumann A, Klein D, GlockZin G, Popp FC, et al. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signaling-transducer and activator of transcription 3/hypoxia-inducible factor-1 alpha autocrine loop, and reduces orthotopic tumor growth. Clin Cancer Res 2007; 13: 6459-6468.
24. Namba T, Koike H, Murakami K, Aoki M, Makino H, Hashiya N, et al. Angiogenesis induced by endothelial nitric oxide synthase gene through vascular endothelial growth factor expression in a rat hindlimb ischemia model. Circulation 2003; 108: 2250-2257.
25. Miyata M, Biro S, Kaieda H, Eto H, Orihara K, Kihara T, et al. Apolipoprotein J/clusterin is induced in vascular smooth muscle cells after vascular injury. Circulation 2001; 104: 1407-1412.
26. Hamada N, Miyata M, Eto H, Shirasawa T, Akasaki Y, Nagaki A, et al. Tacrolimus-eluting stent inhibits neointimal hyperplasia via calcineurin/ NFAT signaling in porcine coronary artery model. Atherosclerosis 2010; 208: 97-103.
27. London NR, Whitehead KJ, Li DY. Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis 2009; 12: 149-158.
28. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 2000; 6: 460-463.
29. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003; 304: 505-512.
30. Sarto C, Binz PA, Mocarelli P. Heat shock proteins in human cancer. Electrophoresis 2000; 21: 1218-1226.
31. Ziche M, Morbidelli L, Masini L, Amerini S, Granger HJ, Maggi CA, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 1994; 94: 2036-2044.
32. Arnal JF, Munzel T, Venema RC, James NL, Bai CL, Mitch WE, et al. Interaction between L-arginine and L-glutamine change endothelial NO production: An effect independent of NO synthase substrate availability. J Clin Invest1995; 95: 2565-2572.
33. Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, et al. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol 1997; 150: 1835-1844.
34. Madonna R, De Caterina R. Stem cells and growth factor delivery systems for cardiovascular disease. J Biotechnol 2011; 154: 291-297.
35. Simons M. Angiogenesis: Where do we stand now? Circulation 2005; 111: 1556-1566.
36. Wallez Y, Huber P. Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis. Biochim Biophys Acta 2008; 1778: 794-809.
37. Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGFB-deficient mice. Science 1997; 277: 242-245.