Phantom digit somatotopy: A functional magnetic resonance imaging study in forearm amputees

European Journal of Neuroscience

Volumn 36, Issue 1, 2012, Pages 2098-2106

  Björkman, Anders ^a   Weibull, Andreas ^a   Olsrud, Johan ^a   Henrik Ehrsson, H ^b   Rosén, Birgitta ^a   Björkman Burtscher, Isabella M ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Amputation; Functional magnetic resonance imaging; Reorganization; Somatosensory; Somatotopy

Indexed keywords

ADULT; AGNOSIA; AMPUTATION STUMP; ARM AMPUTATION; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOREARM; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; PRIMARY SOMATOSENSORY CORTEX; PRIORITY JOURNAL; SENSORY STIMULATION; SKIN SENSITIVITY; TACTILE STIMULATION;

ADULT; AMPUTATION STUMPS; AMPUTEES; ELECTRIC STIMULATION; FEMALE; FOREARM; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PHANTOM LIMB; PHYSICAL STIMULATION; SOMATOSENSORY CORTEX; TOUCH;

EID: 84863189578     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2012.08099.x     Document Type: Article

References (36)

1. Benjamini, Y. & Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc., 57, 289-300.
2. Borsook, D., Becerra, L., Fishman, S., Edwards, A., Jennings, C., Stojanovic, M., Papinicolas, L., Ramachandran, V., Gonzalez, R. & Breiter, H. (1998) Acute plasticity in the human somatosensory cortex following amputation. NeuroReport, 9, 1013-1017.
3. Brugger, P., Kollias, S.S., Muri, R.M., Crelier, G., Hepp-Reymond, M.C. & Regard, M. (2000) Beyond re-membering: phantom sensations of congenitally absent limbs. Proc. Natl Acad. Sci. USA, 97, 6167-6172.
4. Buhmann, C., Glauche, V., Sturenburg, H.J., Oechsner, M., Weiller, C. & Buchel, C. (2003) Pharmacologically modulated fMRI--cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain, 126, 451-461.
5. Calford, M.B. & Tweedale, R. (1990) Interhemispheric transfer of plasticity in the cerebral cortex. Science, 249, 805-807.
6. Chen, R., Cohen, L.G. & Hallett, M. (2002) Nervous system reorganization following injury. Neuroscience, 111, 761-773.
7. Dostrovsky, J.O. (1999) Immediate and long-term plasticity in human somatosensory thalamus and its involvement in phantom limbs. Pain, Aug(Suppl 6), S37-S43.
8. Ehrsson, H.H. (2001) Neural correlats of skilled movements. Thesis, Karolinska Institute, Stockholm.
9. Ehrsson, H.H., Geyer, S. & Naito, E. (2003) Imagery of voluntary movement of fingers, toes, and tongue activates corresponding body-part-specific motor representations. J. Neurophysiol., 90, 3304-3316.
10. Ehrsson, H.H., Spence, C. & Passingham, R.E. (2004) That's my hand! Activity in premotor cortex reflects feeling of ownership of a limb. Science, 305, 875-877.
11. Ehrsson, H.H., Holmes, N.P. & Passingham, R.E. (2005) Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areas. J. Neurosci., 25, 10564-10573.
12. Ehrsson, H.H., Rosen, B., Stockselius, A., Ragno, C., Kohler, P. & Lundborg, G. (2008) Upper limb amputees can be induced to experience a rubber hand as their own. Brain, 131, 3443-3452.
13. Florence, S.L. & Kaas, J.H. (1995) Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys. J. Neurosci., 15, 8083-8095.
14. Friston, K.J., Josephs, O., Zarahn, E., Holmes, A.P., Rouquette, S. & Poline, J. (2000) To smooth or not to smooth? Bias and efficiency in fMRI time-series analysis. Neuroimage, 12, 196-208.
15. Grusser, S.M., Winter, C., Muhlnickel, W., Denke, C., Karl, A., Villringer, K. & Flor, H. (2001a) The relationship of perceptual phenomena and cortical reorganization in upper extremity amputees. Neuroscience, 102, 263-272.
16. Grusser, S.M., Winter, C., Schaefer, M., Fritzsche, K., Benhidjeb, T., Tunn, P., Schlag, P.M. & Flor, H. (2001b) Perceptual phenomena after unilateral arm amputation: a pre-post-surgical comparison. Neurosci. Lett., 302, 13-16.
17. Grusser, S.M., Muhlnickel, W., Schaefer, M., Villringer, K., Christmann, C., Koeppe, C. & Flor, H. (2004) Remote activation of referred phantom sensation and cortical reorganization in human upper extremity amputees. Exp. Brain Res., 154, 97-102.
18. Iwamura, Y. (1998) Hierarchical somatosensory processing. Curr. Opin. Neurobiol., 8, 522-528.
19. Kaas, J.H. & Florence, S.L. (1997) Mechanisms of reorganization in sensory systems of primates after peripheral nerve injury. Adv. Neurol., 73, 147-158.
20. Kaas, J.H., Florence, S.L. & Jain, N. (1999) Subcortical contributions to massive cortical reorganizations. Neuron, 22, 657-660.
21. Kew, J.J., Ridding, M.C., Rothwell, J.C., Passingham, R.E., Leigh, P.N., Sooriakumaran, S., Frackowiak, R.S. & Brooks, D.J. (1994) Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J. Neurophysiol., 72, 2517-2524.
22. Kooijman, C.M., Dijkstra, P.U., Geertzen, J.H., Elzinga, A. & van der Schans, C.P. (2000) Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain, 87, 33-41.
23. Kuiken, T.A., Marasco, P.D., Lock, B.A., Harden, R.N. & Dewald, J.P. (2007a) Redirection of cutaneous sensation from the hand to the chest skin of human amputees with targeted reinnervation. Proc. Natl Acad. Sci. USA, 104, 20061-20066.
24. Kuiken, T.A., Miller, L.A., Lipschutz, R.D., Lock, B.A., Stubblefield, K., Marasco, P.D., Zhou, P. & Dumanian, G.A. (2007b) Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study. Lancet, 369, 371-380.
25. MacIver, K., Lloyd, D.M., Kelly, S., Roberts, N. & Nurmikko, T. (2008) Phantom limb pain, cortical reorganization and the therapeutic effect of mental imagery. Brain, 131, 2181-2191.
26. Makin, T.R., Holmes, N.P. & Ehrsson, H.H. (2008) On the other hand: dummy hands and peripersonal space. Behav. Brain Res., 191, 1-10.
27. Marasco, P.D., Schultz, A.E. & Kuiken, T.A. (2009) Sensory capacity of reinnervated skin after redirection of amputated upper limb nerves to the chest. Brain, 132, 1441-1448.
28. Merzenich, M.M., Nelson, R.J., Stryker, M.S., Cynader, M.S., Schoppman, A. & Zook, J.M. (1984) Somatosensory cortical map changes following digit amputation in adult monkeys. J. Comp. Neurol., 224, 591-605.
29. Naito, E., Roland, P.E. & Ehrsson, H.H. (2002) I feel my hand moving: a new role of the primary motor cortex in somatic perception of limb movement. Neuron, 36, 979-988.
30. Ramachandran, V.S. (2000) Phantom limbs and neural plasticity. Arch. Neurol., 57, 317-320.
31. Ramachandran, V.S., Stewart, M. & Rogers-Ramachandran, D.C. (1992) Perceptual correlates of massive cortical reorganization. NeuroReport, 3, 583-586.
32. Rosen, B., Ehrsson, H.H., Antfolk, C., Cipriani, C., Sebelius, F. & Lundborg, G. (2009) Referral of sensation to an advanced humanoid robotic hand prosthesis. Scand. J. Plast. Reconstr. Surg. Hand Surg., 43, 260-266.
33. Talaraich, J. & Tournoux, P. 1988. Co-planar Stereotaxic Atlas of the Human Brain. Thieme, Stuttgart.
34. Wall, J.T., Xu, J. & Wang, X. (2002) Human brain plasticity: an emerging view of the multiple substrates and mechanisms that cause cortical changes and related sensory dysfunctions after injuries of sensory inputs from the body. Brain Res. Brain Res. Rev., 39, 181-215.
35. Weibull, A., Bjorkman, A., Hall, H., Rosen, B., Lundborg, G. & Svensson, J. (2008) Optimizing the mapping of finger areas in primary somatosensory cortex using functional MRI. Magn. Reson. Imaging, 26, 1342-1351.
36. Wu, C.W. & Kaas, J.H. (2002) The effects of long-standing limb loss on anatomical reorganization of the somatosensory afferents in the brainstem and spinal cord. Somatosens. Mot. Res., 19, 153-163.