Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 5, 2012, Pages 1708-1712

  Tan, Xin Jie ^a   Dai, Yu Bing ^a   Wu, Wan Fu ^a   Kim, Hyun Jin ^a   Barros, Rodrigo P A ^a   Richardson, Timothy I ^b   Yaden, Benjamin C ^b   Warner, Margaret ^a   McKinzie, David L ^b   Krishnan, Venkatesh ^b   Gustafsson, Jan Åke ^a,c  

^a University of Houston   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c Center for Biosciences   (Sweden)

Author keywords

Cerebral cortex; Glutamate toxicity; Hippocampus; Neurotransmitter

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ESTRADIOL; ESTROGEN RECEPTOR BETA; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DECARBOXYLASE; HORMONE RECEPTOR STIMULATING AGENT; LY 3201; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; DENDRITIC SPINE; GABAERGIC SYSTEM; GOLGI COMPLEX; HIPPOCAMPUS; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; BENZOPYRANS; BRAIN; DENDRITIC SPINES; ESTROGEN RECEPTOR BETA; GAMMA-AMINOBUTYRIC ACID; LIGANDS; MICE; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

MUS;

EID: 84863168308     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121162109     Document Type: Article

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