Transplantation of ex vivo expanded bone marrow-derived endothelial progenitor cells enhances chronic venous thrombus resolution and recanalization

Clinical and Applied Thrombosis/Hemostasis

Volumn 17, Issue 6, 2011, Pages

  Meng, Qingyou ^a   Li, Xiaoqiang ^a   Yu, Xiaobin ^a   Lei, Fengrui ^a   Jiang, Kun ^a   Li, Chuanyong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

deep vein thrombosis; endothelial progenitor cells (EPCs); postthrombotic syndrome; recanalization; thrombus resolution

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; HEMATOPOIETIC STEM CELL; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECANALIZATION; STEM CELL EXPANSION; STEM CELL TRANSPLANTATION; THROMBUS; WESTERN BLOTTING;

ANIMALS; BONE MARROW TRANSPLANTATION; CATHETERS, INDWELLING; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; STEM CELL TRANSPLANTATION; STEM CELLS; THROMBOSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENOUS THROMBOSIS;

EID: 84863160051     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029610397180     Document Type: Article

References (30)

1. Kearon C. Natural history of venous thromboembolism. Circulation. 2003 ; 107: I22 - I30
2. Levine MN, Raskob G, Beyth RJ, Kearon C, Schulman S. Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 ; 126 (3 suppl). 287S - 310S (Pubitemid 39297958)
3. Modarai B, Burnand KG, Humphries J, Waltham M, Smith A. The role of neovascularisation in the resolution of venous thrombus. Thromb Haemost. 2005 ; 93 (5). 801-809 (Pubitemid 40691533)
4. McGuinness CL, Humphries J, Waltham M, Burnand KG, Collins M, Smith A. Recruitment of labelled monocytes by experimental venous thrombi. Thromb Haemost. 2001 ; 85 (6). 1018-1024 (Pubitemid 32573753)
5. Crosby JR, Kaminski WE, Schatteman G, et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res. 2000 ; 87 (9). 728-730
6. Kawamoto A, Gwon HC, Iwaguro H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 2001 ; 103 (5). 634-637 (Pubitemid 32144189)
7. Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Transplanted adult bone marrow cells repair myocardial infarcts in mice. Ann N Y Acad Sci. 2001 ; 938 (6). 221-229
8. Modarai B, Burnand KG, Sawyer B, Smith A. Endothelial progenitor cells are recruited into resolving venous thrombi. Circulation. 2005 ; 111 (20). 2645-2653 (Pubitemid 40740865)
9. Moldovan NI. Role of monocytes and macrophages in adult angiogenesis: a light at the tunnel's end. J Hematotherap Stem Cell Res. 2002 ; 11 (2). 179-194 (Pubitemid 34309514)
10. Li XQ, Meng QY, Wu HR. Effects of bone marrow-derived endothelial progenitor cell transplantation on vein microenvironment in a rat model of chronic thrombosis. Chin Med J. 2007 ; 120 (4). 2245-2249
11. Wakefield TW, Linn MJ, Henke PK, et al. Neovascularization during venous thrombosis organization: a preliminary study. J Vasc Surg. 1999 ; 30 (5). 885-893 (Pubitemid 29534186)
12. Humphries J, McGuinness CL, Smith A, Waltham M, Poston R, Burnand KG. Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi. J Vasc Surg. 1999 ; 30 (5). 894-899
13. Clark RA. Biology of dermal wound repair. Dermatol Clin. 1993 ; 11 (4). 647-666 (Pubitemid 23313910)
14. Soo KS, Northeast AD, Happerfield LC, Burnand KG, Bobrow LG. Tissue plasminogen activator production by monocytes in venous thrombolysis. J Pathol. 1996 ; 178 (2). 190-194 (Pubitemid 26057971)
15. Singh I, Burnand KG, Collins M, et al. Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells. Circulation. 2003 ; 107 (6). 869-875 (Pubitemid 36241046)
16. Waltham M, Burnand KG, Collins M, Smith A. Vascular endothelial growth factor and basic fibroblast growth factor are found in resolving venous thrombi. J Vasc Surg. 2000 ; 32 (5). 988-996
17. Henke PK, Wakefield TW, Kadell AM, et al. Interleukin-8 administration enhances venous thrombosis resolution in a rat model. J Surg Res. 2001 ; 99 (1). 84-91 (Pubitemid 32613963)
18. Northeast ADR, Burnand KG. The response of the vessel wall to thrombosis: The in vivo study of venous thrombolysis. Ann NY Acad Sci. 1992 ; 667 (12). 127-140 (Pubitemid 23061571)
19. Varma MR, Moaveni DM, Dewyer NA, et al. Deep vein thrombosis resolution is not accelerated with increased neovascularization. J Vasc Surg. 2004 ; 40 (3). 536-542 (Pubitemid 39165031)
20. Ali T, Humphries J, Burnand KG, et al. Monocyte recruitment in venous thrombus resolution. J Vasc Surg. 2006 ; 43 (3). 601-608 (Pubitemid 43332750)
21. Henke PK, Varma MR, Deatrick KB, et al. Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization. Thromb Haemost. 2006 ; 95 (2). 272-281
22. Tanaka K, Hrst AE, Smith LL. Rate of endothelialization in venous thrombi: an experimental study. Arch Surg. 1982 ; 117 (8). 1045-1048 (Pubitemid 12038738)
23. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997 ; 275 (5302). 964-967 (Pubitemid 27087709)
24. Kang HJ, Kim DS, Zhang SY, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004 ; 363 (9411). 751-756
25. Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 2003 ; 107 (18). 2294-2302 (Pubitemid 36578498)
26. Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002 ; 106 (15). 1913-1918 (Pubitemid 35176294)
27. Moldovan NI, Asahara T. Role of blood mononuclear cells in recanalization and vascularization of thrombi: past, present, and future. Trends Cardiovasc Med. 2003 ; 13 (7). 265-269 (Pubitemid 37159390)
28. Thurston G. Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage. J Anat. 2002 ; 200 (6). 575-580 (Pubitemid 34823049)
29. Lubiatowski P, Gurunluoglu R, Goldman CK, Skugor B, Carnevale K, Siemionow M. Gene therapy by adenovirus-mediated vascular endothelial growth factor and angiopoietin-1 promotes perfusion of muscle flaps. Plast Reconstr Surg. 2002 ; 110 (1). 149-159 (Pubitemid 34686263)
30. Waltham M, Burnand KG, Fenske C, Modarai B, Humphries J, Smith A. Vascular endothelial growth factor naked DNA gene transfer enhances thrombus recanalization and resolution. J Vasc Surg. 2005 ; 42 (6). 1183-1189 (Pubitemid 41817176)