Optimization of a floating osmotic pump system of ambroxol hydrochloride using central composite design-response surface methodology and its pharmacokinetics in Beagle dogs

Yaoxue Xuebao

Volumn 46, Issue 12, 2011, Pages 1507-1514

  Zhao, Feng ^a   Ma, Yin Ling ^a,b   Jin, Xiao Li ^a,c   Wang, Jing ^a   Cao, De Ying ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI GENERAL HOSPITAL   (China)

^c CSPC   (China)

Author keywords

Ambroxol hydrochloride; Central composite design; Floating; Osmotic pump; Response surface

Indexed keywords

AMBROXOL; GLUCOSE;

ARTICLE; BIOEQUIVALENCE; CORRELATION COEFFICIENT; DOG; DRUG COATING; DRUG DESIGN; DRUG FORMULATION; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSMOTIC PUMP;

ABSORPTION; ADMINISTRATION, ORAL; AMBROXOL; ANIMALS; AREA UNDER CURVE; CAPSULES; DELAYED-ACTION PREPARATIONS; DOGS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FEMALE; GLUCOSE; MALE; OSMOSIS; OSMOTIC PRESSURE; POROSITY; RANDOM ALLOCATION; SOLUBILITY; THERAPEUTIC EQUIVALENCY;

EID: 84863151377     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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