Optimization of ambroxol hydrochloride sustained-release tablets formulation by central composite design-response surface methodology

Journal of China Pharmaceutical University

Volumn 38, Issue 1, 2007, Pages 39-42

  Zhou, Yun Fei ^a   Wang, Bo ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ambroxol hydrochoride; Central composite design; Overlay contour plot; Respose surface methodology; Sustained release tablets

Indexed keywords

AMBROXOL; LACTOSE;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG RELEASE; FACTORIAL ANALYSIS; IN VITRO STUDY; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; METHODOLOGY; PREDICTION; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REFERENCE VALUE; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; SUSTAINED RELEASE FORMULATION; TABLET FORMULATION;

EID: 33847387959     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Luo AZ. Mod Med Health, 2006,22(3):389.
2. Zhu CL, Li YH, Tian ZF. Hebei Med J, 2005,27(12):899-900.
3. Giannakou SA, Dallas PP, Rekkas DM, et al. In vitro evaluation of nimodipine permeation through human epidermis using response surface methodology [J]. Int J Pharm, 2002,241(1):27-34.
4. Kagkadis KA, Rekkas DM, Dallas PP, et al. A freeze-dried injection form of flurbiprofen: development and optimization using response surface methodology [J]. Int J Pharm, 1998,161(1):87-94.
5. Zhao G, Ping QN, Luan Y. J China Pharm Univ, 2004, 35 (2): 122-126.
6. Lu B, Xu GJ. Chin Pharm,2000,35(7):452-454.