The recombinant kringle domain of urokinase plasminogen activator inhibits VEGF165-induced angiogenesis of HUVECs by suppressing VEGFR2 dimerization and subsequent signal transduction

IUBMB Life

Volumn 64, Issue 3, 2012, Pages 259-265

  Kim, Byeong Mo ^a   Lee, Dong Heon ^a   Choi, Hyun Jin ^a   Lee, Kee Ho ^a   Kang, Su Jin ^b   Joe, Young Ae ^c   Hong, Yong Kil ^c   Hong, Sung Hee ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Daegu Haany University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

HUVEC; matrix metalloproteinases (MMPs); migration; proliferation; recombinant kringle domain (UK1) of urokinase plasminogen activator (uPA); VEGFR2 dimerization

Indexed keywords

GELATINASE A; RECOMBINANT UROKINASE; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; DIMERIZATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KRINGLE DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

ANGIOGENESIS INDUCING AGENTS; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DIMERIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KRINGLES; MATRIX METALLOPROTEINASE 2; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84863143859     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.604     Document Type: Article

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