Health effects of low-level cadmium intake and the role of metallothionein on cadmium transport from mother rats to fetus

Journal of Toxicological Sciences

Volumn 37, Issue 1, 2012, Pages 149-156

  Nakamura, Yasuhiro ^a   Ohba, Ken Ichi ^a   Suzuki, Keiji ^b   Ohta, Hisayoshi ^a  

^a KITASATO UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

Cadmium; Metallothionein; Placenta; Uterus

Indexed keywords

CADMIUM; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; GENE EXPRESSION; KIDNEY; NEWBORN; NONHUMAN; PLACENTA; PLACENTAL TRANSFER; RAT; TISSUE LEVEL; UTERUS;

RATTUS; RATTUS NORVEGICUS;

EID: 84863143091     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.149     Document Type: Article

References (29)

1. Arizono, K., Ota, S. and Ariyoshi, T. (1981): Purification of metallothionein-like protein in rat placenta. Bull. Environ. Contam. Toxicol., 27, 671-677
2. Bremner, I. (1987): Nutritional and physiological significance of metallothionein. Experientia Suppl., 52, 81-107
3. Brzoska, M.M. and Moniuszko-Jakoniuk, J. (2004): Low-level exposure to cadmium during the lifetime increases the risk of osteoporosis and fractures of the lumbar spine in the elderly: studies on a rat model of human environmental exposure. Toxicol. Sci., 82, 468-477
4. Carey, L.C., Coyle, P., Philcox, J.C. and Rofe, A.M. (2000): Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice. Alcohol. Clin. Exp. Res., 24, 1236-1240
5. Chan, H.M. and Cherian, M.G. (1993): Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats. Biochem. Cell Biol., 71, 133-140
6. Chan, H.M., Tamura, Y., Cherian, M.G. and Goyer, R.A. (1993): Pregnancy-associated changes in plasma metallothionein concentration and renal cadmium accumulation in rats. Proc. Soc. Exp. Biol. Med., 202, 420-427
7. Ferguson, C.J., Wareing, M., Ward, D.T., Green, R., Smith, C.P. and Riccardi, D. (2001): Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am. J. Physiol. Renal Physiol., 280, F803-F814.
8. Grotz, N., Fox, T., Connolly, E., Park, W., Guerinot, M.L. and Eide, D. (1998): Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc. Natl. Acad. Sci. USA., 95, 7220-7224
9. Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., Gollan, J.L. and Hediger, M.A. (1997): Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388, 482-488
10. Goyer, R.A. (1991): Transplacental transfer of cadmium and fetal effects. Fundam. Appl. Toxicol., 16, 22-23
11. Goyer, R.A., Haust, M.D. and Cherian, M.G. (1992): Cellular localization of metallothionein in human term placenta. Placenta, 13, 349-355
12. Hazelhoff Roelfzema, W., Tohyama, C., Nishimura, H., Nishimura, N. and Morselt, A.F. (1989): Quantitative immunohistochemistry of metallothionein in rat placenta. Histochemistry, 90, 365-369
13. Honda, A., Komuro, H., Shimada, A., Hasegawa, T., Seko, Y., Nagase, H., Hozumi, I., Inuzuka, T., Hara, H., Fujiwara, Y. and Satoh, M. (2010): Attenuation of cadmium-induced testicular injury in metallothionein-III null mice. Life Sci., 87, 545-550
14. Honda, R., Tsuritani, I., Noborisaka, Y., Suzuki, H., Ishizaki, M. and Yamada, Y. (2003): Urinary cadmium excretion is correlated with calcaneal bone mass in Japanese women living in an urban area. Environ. Res., 91, 63-70
15. Itoh, N., Fujita, Y., Nakanishi, H., Kawai, Y., Mayumi, T., Hwang, G.S., Min, K., Onosaka, S., Muto, N. and Tanaka, K. (1996): Binding of Cd to metallothionein in the placenta of Cd-treated mouse. J. Toxicol. Sci., 21, 19-27
16. Jarup, L. (2002): Cadmium overload and toxicity. Nephrol. Dial. Transplant., 17, 35-39
17. Kagi, J.H. and Valee, B.L. (1960): Metallothionein: a cadmium-and zinc-containing protein from equine renal cortex. J. Biol. Chem., 235, 3460-3465
18. Lau, J.C., Joseph, M.G. and Cherian, M.G. (1998): Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Toxicol., 127, 167-178
19. Levin, A.A., Plautz, J.R., di Sant'Agnese, P.A. and Miller, R.K. (1981): Cadmium: placental mechanisms of fetal toxicity. Placenta Suppl., 3, 303-318
20. Margoshes, M. and Vallee, B.L. (1957): A Cadmium protein from equine kidney cortex. J. Am. Chem. Soc., 79, 4813-4814
21. Nakajima, K., Suzuki, K., Otaki, N. and Kimura, M. (1991): Detection of metallothionein in brain. Methods Enzymol., 205, 387-395
22. Nomiyama, K. and Nomiyama, H. (1982): Tissue metallothioneins in rabbits chronically exposed to cadmium, with special reference to the critical concentration of cadmium in the renal cortex. Dev. Toxicol. Environ. Sci., 9, 47-67
23. Ohta, H. and Cherian, M.G. (1991): Gastrointestinal absorption of cadmium and metallothionein. Toxicol. Appl. Pharmacol., 107, 63-72
24. Ohta, H., Nakakita, M., Tanaka, H., Seki, Y., Yoshikawa, H., (1997): Induction of metallothionein-like cadmium-binding protein in the testis by oral cadmium administration in rats. Ind. Health, 35, 96-103
25. Ohta, H., Yamauchi, Y., Nakakita, M., Tanaka, H., Asami, S., Seki, Y. and Yoshikawa, H. (2000): Relationship between renal dysfunction and bone metabolism disorder in male rats after longterm oral quantitative cadmium administration. Ind. Health, 38, 339-355
26. Onosaka, S., Tanaka, K., Doi, M. and Okahara, K. (1978): A simplified procedure for determination of metallothionein in animal tissues. Eisei Kagaku, 24, 128-131
27. Ronco, A.M., Arguello, G., Suazo, M. and Llanos, M.N. (2005): Increased levels of metallothionein in placenta of smokers. Toxicol., 208, 133-139
28. Tekin, D., Kayaalti, Z., Aliyev, V. and Soylemezoǧlu, T. (2011): The effects of metallothionein 2A polymorphism on placental cadmium accumulation: is metallothionein a modifiying factor in transfer of micronutrients to the fetus? J. Appl. Toxicol., 15, 1661.
29. Yoshida, M., Ohta, H., Yamauchi, Y., Seki, Y., Sagi, M., Yamazaki, K. and Sumi, Y. (1998): Age-dependent changes in metallothionein levels in liver and kidney of the Japanese. Biol. Trace Elem. Res., 63, 167-175.