Ethanol decreases zinc transfer to the fetus in normal but not metallothionein-null mice

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 8, 2000, Pages 1236-1240

  Carey, Luke C ^a,b   Coyle, Peter ^a,b   Philcox, Jeffrey C ^a,b   Rofe, Allan M ^a,b  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Ethanol; Metallothionein; Mice; Pregnancy; Zinc

Indexed keywords

ALCOHOL; METALLOTHIONEIN; ZINC ION;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; FETUS; GENOTYPE; GESTATIONAL AGE; HOMEOSTASIS; MALE; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; TERATOGENICITY; TISSUE DISTRIBUTION; TISSUE LEVEL; ZINC BLOOD LEVEL;

ANIMALIA;

EID: 0033836256     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02089.x     Document Type: Article

References (28)

1. Effect of alcohol and electrical stimulation on leakage of creatine kinase from isolated fast and slow muscles of rat
2. Expression of mouse metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency
3. Maternal ethanol exposure is associated with decreased plasma zinc and increased fetal abnormalities in normal but not metallothionein-null mice
4. Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution
5. Zn-depleted mice absorb more of an intragastric Zn solution by a metallothionein-enhanced process than do Zn-replete mice
6. Absorption, transport and hepatic metabolism of copper and zinc: Special reference to metallothionein and caeruloplasmin
7. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency
8. The teratogenic effect of zinc deficiency and accompanying feeding patterns in mice
9. Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues
10. Relative and combined roles of ethanol and protein malnutrition on muscle zinc, potassium, copper, iron and magnesium
11. Fetal alcohol syndrome: Inhibition of placental zinc transport as a potential mechanism for fetal growth retardation in the rat
12. Foetal skeletal malformations associated with moderate zinc deficiency during pregnancy
13. Teratogenic effects of short term and transitory zinc deficiency in rats
14. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice
15. The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte cultures
16. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity
17. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium
18. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse
19. Prenatal ethanol exposure in mice: Teratogenic effects
20. Zinc homeostasis during pregnancy in metallothionein-null mice on a low zinc diet
21. The role of the pancreas in intestinal zinc secretion in metallothionein-null mice
22. Oxygen free radicals and metallothionein
23. Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumour necrosis factor-α and interleukin-6
24. Circadian modification of ethanol damage in utero to mice
25. Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues
26. Fetal alcohol syndrome: Embryogenesis in a mouse model
27. Tumor necrosis factor-α alters maternal and embryonic zinc metabolism and is developmentally toxic in mice
28. Altered maternal zinc metabolism following exposure to diverse developmental toxicants