Widespread Expression of γ-Glutamyl Cyclotransferase Suggests It Is Not a General Tumor Marker

Journal of Histochemistry and Cytochemistry

Volumn 60, Issue 1, 2012, Pages 76-86

  Amano, Tomonari ^a   Eishi, Yoshinobu ^a   Yamada, Tetsuo ^a   Uchida, Keisuke ^a   Minegishi, Kana ^a   Tamura, Tomoki ^a   Kobayashi, Daisuke ^a   Hiroshi, Kawachi ^a   Suzuki, Takashige ^a   Board, Philip G ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Australian National University   (Australia)

Author keywords

glutamyl cyclotransferase; cancer marker; cellular distribution; gene expression; GGCT; protein expression

Indexed keywords

GAMMA GLUTAMYLCYCLOTRANSFERASE; MONOCLONAL ANTIBODY; TUMOR MARKER;

ARTICLE; BILE DUCT TUMOR; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; ESOPHAGUS TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY TUMOR; LUNG TUMOR; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; STOMACH TUMOR; UROGENITAL TRACT TUMOR; UTERINE CERVIX TUMOR; AGED; ANTIBODY SPECIFICITY; FEMALE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; NEOPLASM; TUMOR CELL LINE;

AGED; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL LINE, TUMOR; FEMALE; GAMMA-GLUTAMYLCYCLOTRANSFERASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASMS; ORGAN SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84863138170     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411428468     Document Type: Article

References (18)

1. Azumi K,Ikeda Y,Takeuchi T,Sorin N,Sabau V,Hamada J,Okada F,Hosokawa M,Yokosawa H.Localization and characterization of gamma-glutamyl cyclotransferase in cancer cells.Mol Med Rep. 2009;2:385-391.
2. Board PG.Electrophoretic investigation of gamma-glutamyl-cyclotransferase from human erythrocytes.Hum Hered. 1980;30:248-250.
3. Board PG,Moore KA,Smith JE.Purification and properties of gamma-glutamylcyclotransferase from human erythrocytes.Biochem J. 1978;173:427-431.
4. Gromov P,Gromova I,Friis E,Timmermans-Wielenga V,Rank F,Simon R,Sauter G,Moreira JM.Proteomic profiling of mammary carcinomas identifies C7orf24, a gamma-glutamyl cyclotransferase, as a potential cancer biomarker.J Proteome Res. 2010;9:3941-3953.
5. Harlow E,Lane D Antibodies: A laboratory manual. New York: Cold Spring Harbor Laboratory Press; 1988:.
6. Kageyama S,Iwaki H,Inoue H,Isono T,Yuasa T,Nogawa M,Maekawa T,Ueda M,Kajita Y,Ogawa O, et al.A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.Proteomics Clin Appl. 2007;1:192-199.
7. Laemmli UK.Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature. 1970;15:680-685.
8. Meister A.On the enzymology of amino acid transport.Science. 1973;180:33-39.
9. Meister A,Anderson ME.Glutathione.Annu Rev Biochem. 1983;52:711-760.
10. Oakley AJ,Yamada T,Liu D,Coggan M,Clark AG,Board PG.The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase: an essential enzyme in the gamma-glutamyl cycle.J Biol Chem. 2008;283:22031-22042.
11. Oda K,Makino S,Masuda C,Yoshiki T,Kitamura Y,Takata K,Yanagisawa D,Taniguchi T,Tooyama I.The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues.J Histochem Cytochem. 2009;57:1121-1126.
12. Orlowski M,Meister A.γ-Glutamyl cyclotransferase: distribution, isozymic forms, and specificity.J Biol Chem. 1973;248:2836-2844.
13. Orlowski M,Richman PG,Meister A.Isolation and properties of gamma-L-glutamylcyclotransferase from human brain.Biochemistry. 1969;8:1048-1055.
14. Smith JE,Moore K,Board PG.Regulation of gamma-glutamylcysteine utilization in erythrocytes.Enzyme. 1980;25:236-240.
15. Uejima D,Nishijo K,Kajita Y,Ishibe T,Aoyama T,Kageyama S,Iwaki H,Nakamura T,Iida H,Yoshiki T, et al.Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma.Anticancer Res. 2011;31:1297-1305.
16. Wellner VP,Sekura R,Meister A,Larsson A.Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria).Proc Natl Acad Sci U S A. 1974;71:2505-2509.
17. Xu L,Geman D,Winslow RL.Large-scale integration of cancer microarray data identifies a robust common cancer signature.BMC Bioinformatics. 2007;8:275.
18. Zhang C,Li HR,Fan JB,Wang-Rodriguez J,Downs T,Fu XD,Zhang MQ.Profiling alternatively spliced mRNA isoforms for prostate cancer classification.BMC Bioinformatics. 2006;7:202.