The virion-associated open reading frame 49 of murine gammaherpesvirus 68 promotes viral replication both In Vitro and In Vivo as a derepressor of RTA

Journal of Virology

Volumn 86, Issue 2, 2012, Pages 1109-1118

  Noh, Cheol Woo ^a   Cho, Hye Jeong ^a   Kang, Hye Ri ^a   Jin, Hyun Yong ^a   Lee, Shaoying ^b   Deng, Hongyu ^b   Wu, Ting Ting ^b   Arumugaswami, Vaithilingaraja ^b   Sun, Ren ^b   Song, Moon Jung ^a  

^a Korea University   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GAMMAHERPESVIRINAE; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MURINE GAMMAHERPES VIRUS 68; NONHUMAN; OPEN READING FRAME 49 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION; RTA GENE; VIRION; VIROGENESIS; VIRUS GENE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN;

ANIMALS; CELL LINE; CRICETINAE; GAMMAHERPESVIRINAE; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRIDAE INFECTIONS; HUMANS; IMMEDIATE-EARLY PROTEINS; MICE; OPEN READING FRAMES; RODENT DISEASES; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRION; VIRUS REPLICATION;

MIRIDAE; MURINAE; MURINE HEPATITIS VIRUS; MUS;

EID: 84863127136     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05785-11     Document Type: Article

References (43)

1. Akula SM, Pramod NP, Wang F-Z, Chandran B. 2002. Integrin α3β1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108:407-419.
2. Bortz E, et al. 2007. Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm. J. Virol. 81:10137-10150.
3. Bortz E, et al. 2003. Identification of proteins associated with murine gammaherpesvirus 68 virions. J. Virol. 77:13425-13432.
4. Boussif O, et al. 1995. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U. S. A. 92:7297-7301.
5. Calderwood MA, et al. 2007. Epstein-Barr virus and virus human protein interaction maps. Proc. Natl. Acad. Sci. U. S. A. 104:7606-7611.
6. Chen J, Ueda K, Sakakibara S, Okuno T, Yamanishi K. 2000. Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J. Virol. 74:8623-8634.
7. Deng B, O'Connor CM, Kedes DH, Zhou ZH. 2008. Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation. J. Struct. Biol. 161:419-427.
8. Deng H, Liang Y, Sun R. 2007. Regulation of KSHV lytic gene expression. Curr. Top. Microbiol. Immunol. 312:157-183.
9. Ebrahimi B, et al. 2003. Transcriptome profile of murine gammaherpesvirus-68 lytic infection. J. Gen. Virol. 84:99-109.
10. Ganem D. 2007. Kaposi's sarcoma-associated herpesvirus, 5th ed, vol 2. Lippincott Williams & Wilkins, Hagerstown, MD.
11. González CM, et al. 2006. Identification and characterization of the ORF49 protein of Kaposi's sarcoma-associated herpesvirus. J. Virol. 80: 3062-3070.
12. Guo H, Wang L, Peng L, Zhou ZH, Deng H. 2009. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. J. Virol. 83:10582-10595.
13. Gwack Y, et al. 2003. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol. Cell. Biol. 23:2055-2067.
14. Gwack Y, Byun H, Hwang S, Lim C, Choe J. 2001. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J. Virol. 75:1909-1917.
15. Gwack Y, et al. 2003. Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol. Cell. Biol. 23:8282-8294.
16. Hagemeier SR, Barlow EA, Kleman AA, Kenney SC. 2011. The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2- and p53-dependent manner. J. Virol. 85:4318-4329.
17. Hong GK, et al. 2004. The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1. J. Virol. 78:4983-4992.
18. Kickhoefer VA, et al. 1999. The 193-kD Vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J. Cell Biol. 146:917-928.
19. + into a nuclear signal. Gene Dev. 19: 1951-1967.
20. Kraus WL. 2008. Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr. Opin. Cell Biol. 20:294-302.
21. Lee S, et al. 2007. The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication. J. Virol. 81: 9870-9877.
22. Lukac DM, Kirshner JR, Ganem D. 1999. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73: 9348-9361.
23. Lukac DM, Renne R, Kirshner JR, Gamen D. 1998. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF50 transactivator, a homolog of the EBV R protein. Virology 252:304-312.
24. Luxton GWG, et al. 2005. Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins. Proc. Natl. Acad. Sci. U. S. A. 102:5832-5837.
25. Martinez-Guzman D, et al. 2003. Transcription program of murine gammaherpesvirus 68. J. Virol. 77:10488-10503.
26. Mettenleiter TC, Kupp BG, Granzow H. 2006. Herpesvirus assembly: a tale of two membranes. Curr. Opin. Microbiol. 9:423-429.
27. Nash AA, Dutia BM, Stewart JP, Davison AJ. 2001. Natural history of murine γ-herpesvirus infection. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356:569-579.
28. O'Connor CM, Kedes DH. 2006. Mass spectrometric analyses of purified rhesus monkey rhadinovirus reveal 33 virion-associated proteins. J. Virol. 80:1574-1583.
29. Pellett PE, Roizman B. 2007. The family Herpesviridae: a brief introduction, 5th ed, vol 2. Lippincott Williams & Wilkins, Hagerstown, MD.
30. Rickinson AB, Kieff E. 2007. Epstein-Barr virus, 5th ed, vol 2. Lippincott Williams & Wilkins, Hagerstown, MD.
31. Rozen R, Sathish N, Li Y, Yuan Y. 2008. Virion-wide interactions of Kaposi's sarcoma-associated herpesvirus. J. Virol. 82:4742-4750.
32. Segouffin-Cariou C, Farjot G, Sergeant A, Gruffat H. 2000. Characterization of the Epstein-Barr virus BRRF1 gene, located between early genes BZLF1 and BRLF1. J. Gen. Virol. 81:1791-1799.
33. Smith GA, Enquist LW. 1999. Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus. J. Virol. 73:6405-6414.
34. Song MJ, et al. 2005. Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis. Proc. Natl. Acad. Sci. U. S. A. 102:3805-3810.
35. Staudt MR, Dittmer DP. 2007. The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr. Top. Microbiol. Immunol. 312:71-100.
36. Sun R, et al. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. U. S. A. 95:10866-10871.
37. Swenson JJ, Holley-Guthrie E, Kenney SC. 2001. Epstein-Barr virus immediate-early protein BRLF1 interacts with CBP, promoting enhanced BRLF1 transactivation. J. Virol. 75:6228-6234.
38. Wang J, et al. 2005. Modulation of human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus replication and transcription activator transactivation by interferon regulatory factor 7. J. Virol. 79:2420-2431.
39. Wang S, Liu S, Wu M-H, Gene Y, Wood C. 2001. Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. J. Virol. 75:11961-11973.
40. Womack A, Shenk T. 2010. Human cytomegalovirus tegument protein pUL71 is required for efficient virion egress. mBio 1(5):e00282-10. doi: 10.1128/mBio.00282-10.
41. Wu TT, Usherwood EJ, Stewart JP, Nash AA, Sun R. 2000. Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency. J. Virol. 74:3659-3667.
42. Ye J, Shedd D, Miller G. 2005. An Sp1 response element in the Kaposi's sarcoma-associated herpesvirus open reading frame 50 promoter mediates lytic cycle induction by butyrate. J. Virol. 79:1397-1408.
43. Zhong W, Wang H, Hernidier B, Ganem D. 1996. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc. Natl. Acad. Sci. U. S. A. 93:6641-6646.