Structure based design and synthesis of peptide inhibitor of human lox-12: In vitro and in vivo analysis of a novel therapeutic agent for breast cancer

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Singh, Abhay kumar ^a   Singh, Ratnakar ^a   Naz, Farhat ^a   Chauhan, Shyam Singh ^a   Dinda, Amit ^a   Shukla, Abhay Anand ^a   Gill, Kamaldeep ^a   Kapoor, Vaishali ^a   Dey, Sharmistha ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLISOLEUCYLTYROSYLTRYPTOPHAN; ANTINEOPLASTIC AGENT; ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; ESTROGEN RECEPTOR; LIPOXYGENASE INHIBITOR; PHENYLALANYLTRYPTOPHANYLTYROSINE; PHENYLALANYLTRYPTOPHYLCYSTEINYLSERINE; PHENYLALANYLTYROSYLSERINE; TRYPTOPHYLLYSYLSERINE; TRYPTOPHYLPHENYLALANYLALANINE; TRYPTOPHYLPHENYLALANYLCYSTEINE; TYROSYLTRYPTOPHAN; TYROSYLTRYPTOPHYLCYSTEINYLSERINE; TYROSYLTRYPTOPHYLGLYCINE; UNCLASSIFIED DRUG; ESTROGEN; PEPTIDE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; SOLID PHASE SYNTHESIS; SURFACE PLASMON RESONANCE; ANIMAL; BREAST TUMOR; CELL SURVIVAL; CHEMISTRY; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; FEMALE; FLOW CYTOMETRY; KINETICS; METABOLISM; METHODOLOGY; PROTEIN BINDING; SYNTHESIS; TUMOR CELL LINE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONATE 12-LIPOXYGENASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESTROGENS; FEMALE; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIPOXYGENASE INHIBITORS; MAMMARY NEOPLASMS, ANIMAL; MICE; PEPTIDES; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 84863126444     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032521     Document Type: Article

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