Effects of acute low-dose ethanol on inflammatory reactions to endotoxin-induced shock in rats

Journal of Toxicological Sciences

Volumn 37, Issue 3, 2012, Pages 649-654

  Ajisaka, Hideyuki ^a   Okajima, Masaki ^a   Goto, Yoshikazu ^a   Taniguchi, Takumi ^a   Inaba, Hideo ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Endotoxin; Ethanol; Interleukin (IL) 10; Interleukin (IL) 6; Tumor necrosis factor (TNF)

Indexed keywords

ACID; ALCOHOL; BASE; CYTOKINE; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 10; INTERLEUKIN 6; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG INHIBITION; ENDOTOXEMIA; ESCHERICHIA COLI; FEMALE; HEMODYNAMICS; INFLAMMATION; INJECTION; LETTER; LOW DRUG DOSE; MALE; METABOLIC ACIDOSIS; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SHOCK; SYSTOLIC BLOOD PRESSURE;

ESCHERICHIA COLI; RATTUS;

EID: 84863114218     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.649     Document Type: Letter

References (15)

1. Cook, R.T. (1998): Alcohol abuse, alcoholism, and damage to the immune system--a review. Alcohol Clin. Exp. Res., 22, 1927-1942.
2. Crews, F.T., Bechara, R., Brown, L.A., Guidot, D.M., Mandrekar, P., Oak, S., Qin, L., Szabo, G., Wheeler, M. and Zo, J. (2006): Cytokines and alcohol. Alcohol Clin. Exp. Res., 30, 720-730.
3. Ellenhorn, M.J. and Barceloux, D.G. (1988): Ethanol. Medical Toxicology. Elsevier, New York, pp.782-789.
4. Fernandez-Sola, J., Junque, A., Estruch, R., Monforte, R., Torres, A. and Urbano-Marquez, A. (1995): High alcohol intake as a risk and prognostic factor for community-acquired pneumonia. Arch. Intern. Med., 155, 1649-1654.
5. Fiorentino, D.F., Zlotnik, A., Mosmann, T.R., Howard, M. and O'Garra, A. (1991): IL-10 inhibits cytokine production by activated macrophages. J. Immunol., 147, 3815-3822.
6. Gross, E.R., Gare, M., Toller, W.G., Kersten, J.R., Warltiler, D.C. and Pagel, P.S. (2001): Ethanol enhances the functional recovery of stunned myocardium independent of K (ATP) channels in dogs. Anesth. Analg., 92, 299-305.
7. Karavitis, J., Murdoch, E.L., Gomez, C.R., Ramirez, L. and Kovacs, E.J. (2008): Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions. J. Interferon Cytokine Res., 28, 413-422.
8. Mandrekar, P., Catalano, D., Girouard, L. and Szabo, G. (1996): Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine, 8, 567-577.
9. Mandrekar, P., Catalano, D., White, B. and Szabo, G. (2006): Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of NF-κB and induction of IL-10. lcohol Clin. Exp. Res., 30, 135-139.
10. Moscovitz, H., Shofer, F., Mignott, H., Behman, A. and Kilpatrick, L. (1994): Plasma cytokine determinations in emergency department patients as a predictor of bacteremia and infectious disease severity. Crit. Care Med., 22, 1102-1107.
11. Szabo, G., Mandrekar, P. and Catalano, D. (1995): Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment. J. Leukoc. Biol., 58, 342-350.
12. Takeda, K. and Akira, S. (2005): Toll-like receptors in innate immunity. Int. Immunol., 17, 1-14.
13. Taniguchi, T., Koido, Y., Aiboshi, J., Yamashita, T., Suzaki, S. and Kurokawa, A. (1999): Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome. Crit. Care Med., 27, 1262-1264.
14. Tonner, P.H., Weiler, N., Paris, A. and Scholz, J. (2003): Sedation and analgesia in the intensive care unit. Curr. Opin. Anaesthesiol., 16, 113-121.
15. Tracey, K.J., Beutler, B., Lowry, S.F., Merryweather, J., Wolpe, S., Milsark, I.W., Hariri, R.J., Fahey. T.J. 3rd, Zentella, A. and Albert, J.D. (1986): Shock and tissue injury induced by recombinant human cachectin. Science, 234, 470-474.