Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: A Danish case-cohort study

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Stegger, Jakob Gerhard ^a   Schmidt, Erik Berg ^a   Tjønneland, Anne ^b   Kopp, Tine Iskov ^c   Sørensen, Thorkild I A ^d   Vogel, Ulla ^e   Overvad, Kim ^a,f  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^f AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA;

ACUTE CORONARY SYNDROME; ADULT; AGE DISTRIBUTION; CARDIOVASCULAR RISK; CASE STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DENMARK; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; IL1B GENE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MEDICAL RECORD REVIEW; OBESITY; PROMOTER REGION; PROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEX RATIO; SINGLE NUCLEOTIDE POLYMORPHISM;

ACUTE CORONARY SYNDROME; COHORT STUDIES; CONFIDENCE INTERVALS; DENMARK; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INCIDENCE; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84863107466     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036829     Document Type: Review

References (28)

1. Dinarello CA, (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27: 519-550.
2. Dinarello CA, (2011) A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur J Immunol 41(5): 1203-1217.
3. Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, et al. (2009) Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS One 4(4): e5073.
4. Bhaskar V, Yin J, Mirza AM, Phan D, Vanegas S, et al. (2011) Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in apolipoprotein E-deficient mice. Atherosclerosis 216(2): 313-320.
5. Kirii H, Niwa T, Yamada Y, Wada H, Saito K, et al. (2003) Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 23(4): 656-660.
6. Olofsson PS, Sheikine Y, Jatta K, Ghaderi M, Samnegard A, et al. (2009) A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. the interleukin-1beta:Interleukin-1 receptor antagonist balance in atherosclerosis. Circ J 73(8): 1531-1536.
7. Iacoviello L, Di Castelnuovo A, Gattone M, Pezzini A, Assanelli D, et al. (2005) Polymorphisms of the interleukin-1beta gene affect the risk of myocardial infarction and ischemic stroke at young age and the response of mononuclear cells to stimulation in vitro. Arterioscler Thromb Vasc Biol 25(1): 222-227.
8. Hansson GK, (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16): 1685-1695.
9. Ross R, (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340(2): 115-126.
10. Ridker PM, Morrow DA, (2003) C-reactive protein, inflammation, and coronary risk. Cardiol Clin 21(3): 315-325.
11. Kershaw EE, Flier JS, (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89(6): 2548-2556.
12. Chen H, Wilkins LM, Aziz N, Cannings C, Wyllie DH, et al. (2006) Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 15(4): 519-529.
13. Vogel U, Jensen MK, Due KM, Rimm EB, Wallin H, et al. (2011) The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. Atherosclerosis.
14. Vangsted AJ, Klausen TW, Abildgaard N, Andersen NF, Gimsing P, et al. (2011) Single nucleotide polymorphisms in the promoter region of the IL1B gene influence outcome in multiple myeloma patients treated with high-dose chemotherapy independently of relapse treatment with thalidomide and bortezomib. Ann Hematol.
15. Tjonneland A, Olsen A, Boll K, Stripp C, Christensen J, et al. (2007) Study design, exposure variables, and socioeconomic determinants of participation in diet, cancer and health: A population-based prospective cohort study of 57,053 men and women in denmark. Scand J Public Health 35(4): 432-441.
16. Vangsted AJ, Klausen TW, Ruminski W, Gimsing P, Andersen NF, et al. (2009) The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT. Bone Marrow Transplant 43(7): 539-545.
17. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, et al. (2007) Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res 624(1-2): 88-100.
18. Vogel U, Christensen J, Wallin H, Friis S, Nexo BA, et al. (2008) Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. Mutat Res 639(1-2): 89-100.
19. Vangsted AJ, Klausen TW, Gimsing P, Andersen NF, Abildgaard N, et al. (2009) A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. Haematologica 94(9): 1274-1281.
20. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH, (1999) The danish national hospital register. A valuable source of data for modern health sciences. Dan Med Bull 46(3): 263-268.
21. Joensen AM, Jensen MK, Overvad K, Dethlefsen C, Schmidt E, et al. (2009) Predictive values of acute coronary syndrome discharge diagnoses differed in the danish national patient registry. J Clin Epidemiol 62(2): 188-194.
22. Kalbfleisch JD, Lawless JF, (1988) Likelihood analysis of multi-state models for disease incidence and mortality. Stat Med 7(1-2): 149-160.
23. Korn EL, Graubard BI, Midthune D, (1997) Time-to-event analysis of longitudinal follow-up of a survey: Choice of the time-scale. Am J Epidemiol 145(1): 72-80.
24. Harrel Jr FE, (2001) Regression modeling strategies. United States of America: Springer-Verlag New York, Inc.
25. Rothman KJ GS, (1998) Modern epidemiology. Philadelphia: Lippincott Williams and Wilkins.
26. Stegger JG, Schmidt EB, Obel T, Berentzen TL, Tjonneland A, et al. (2011) Body composition and body fat distribution in relation to later risk of acute myocardial infarction: A danish follow-up study. Int J Obes (Lond).
27. Knight JC, (2005) Regulatory polymorphisms underlying complex disease traits. J Mol Med (Berl) 83(2): 97-109.
28. Latella MC, de Gaetano M, Di Castelnuovo A, Napoleone E, Lorenzet R, et al. (2009) Interleukin 1 gene cluster, myocardial infarction at young age and inflammatory response of human mononuclear cells. Immunol Invest 38(3-4): 203-219.