Simvastatin mobilizes bone marrow stromal cells migrating to injured areas and promotes functional recovery after spinal cord injury in the rat

Neuroscience Letters

Volumn 521, Issue 2, 2012, Pages 136-141

  Han, Xiaoguang ^a   Yang, Ning ^b   Cui, Yueyi ^b   Xu, Yingsheng ^b   Dang, Gengting ^b   Song, Chunli ^b  

^a TSINGHUA UNIVERSITY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Endogenous; Homing; Mobilization; Simvastatin; Spinal cord injury; Stem cell

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; SIMVASTATIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW STROMAL CELL; BRAIN SIZE; CELL LABELING; CELL LINEAGE; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HISTOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LUMBAR SPINE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; STEM CELL; STROMA CELL; WESTERN BLOTTING;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MOVEMENT; FEMALE; MOTOR ACTIVITY; MULTIPOTENT STEM CELLS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SPINAL CORD; SPINAL CORD INJURIES; STROMAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863094387     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.05.071     Document Type: Article

References (25)

1. Allers C., Sierralta W.D., Neubauer S., Rivera F., Minguell J.J., Conget P.A. Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice. Transplantation 2004, 78:503-508.
2. Bae K.S., Park J.B., Kim H.S., Kim D.S., Park D.J., Kang S.J. Neuron-like differentiation of bone marrow-derived mesenchymal stem cells. Yonsei Medical Journal 2011, 52:401-412.
3. Baek K.H., Lee W.Y., Oh K.W., Tae H.J., Lee J.M., Lee E.J., Han J.H., Kang M.I., Cha B.Y., Lee K.W., Son H.Y., Kang S.K. The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. Journal of Korean Medical Science 2005, 20:438-444.
4. Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. Journal of Neurotrauma 1995, 12:1-21.
5. Bellosta S., Ferri N., Bernini F., Paoletti R., Corsini A. Non-lipid-related effects of statins. Annals of Medicine 2000, 32:164-176.
6. Chen J., Zhang C., Jiang H., Li Y., Zhang L., Robin A., Katakowski M., Lu M., Chopp M. Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. Journal of Cerebral Blood Flow and Metabolism 2005, 25:281-290.
7. Cui X., Chopp M., Zacharek A., Roberts C., Lu M., Savant-Bhonsale S., Chen J. Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSCs treatment of stroke. Neurobiology of Disease 2009, 36:35-41.
8. Dery M.A., Rousseau G., Benderdour M., Beaumont E. Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotor recovery. Neuroscience Letters 2009, 453:73-76.
9. Erices A.A., Allers C.I., Conget P.A., Rojas C.V., Minguell J.J. Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion. Cell Transplantation 2003, 12:555-561.
10. Han X., Yang N., Xu Y., Zhu J., Chen Z., Liu Z., Dang G., Song C. Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. Neuroscience Letters 2011, 487:255-259.
11. Hellal F., Hurtado A., Ruschel J., Flynn K.C., Laskowski C.J., Umlauf M., Kapitein L.C., Strikis D., Lemmon V., Bixby J., Hoogenraad C.C., Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science 2011, 331:928-931.
12. Ide C., Nakai Y., Nakano N., Sero T.B., Yamada Y., Endo K., Noda T., Saito F., Suzuki Y., Fukushima M., Nakatani T. Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat. Brain Research 2010, 1332:32-47.
13. Koda M., Nishio Y., Kamado T., Somerya Y., Okawa A., Mori C., Yoshinaga K., Okada S., Moriya H., Yamzaki M. Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice. Brain Research 2007, 1149:223-231.
14. Kulbatski I., Mothe A.J., Nomura H., Tator C.H. Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma. Current Drug Targets 2005, 6:111-126.
15. Leone A.M., Rutella S., Bonanno G., Abbate A., Rebuzzi A.G., Giovannini S., Galiuto L., Liuzzo G., Andreotti F., Lanza G.A., Contemi A.M., Leone G., Crea F. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. European Heart Journal 2005, 26:1196-1204.
16. Li Y., Zhang D., Zhang Y., He G., Zhang F. Augmentation of neovascularization in murine hindlimb ischemia by combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells transplantation. Journal of Biomedical Science 2010, 17:75.
17. Mann C.M., Lee J.H., Hillyer J., Stammers A.M., Tetzlaff W., Kwon B.K. Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury. Experimental Neurology 2010, 221:285-295.
18. Okano H., Sakaguchi M., Ohki K., Suzuki N., Sawamoto K. Regeneration of the central nervous system using endogenous repair mechanisms. Journal of Neurochemistry 2007, 102:1459-1465.
19. Pannu R., Christie D.K., Barbosa E., Singh I., Singh A.K. Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury. Journal of Neurochemistry 2007, 101:182-200.
20. Patel C.B., Cohen D.M., Ahobila-Vajjula P., Sundberg L.M., Chacko T., Narayana P.A. Effect of VEGF treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced magnetic resonance imaging. Journal of Neurotrauma 2009, 7:1005-1016.
21. Song Q., Wang L., Zhu J., Han X., Li X., Yang Y., Sun Y., Song C. Effect of simvastatin on inducing endothelial progenitor cells homing and promoting bone defect repair. Zhongguo Xiu Fu Chong Jia Wai Ke Za Zhi 2010, 24:1103-1106.
22. Tohill M., Mantovani C., Wiberg M., Terenghi G. Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration. Neuroscience Letters 2004, 362:200-203.
23. Tolwani R.J., Cosgaya J.M., Varma S., Jacob R., Kuo L.E., Shooter E.M. BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system. Journal of Neuroscience Research 2004, 77:662-669.
24. Yang Z., Roy R.R., Zhong H., Zdunowski S., Edgerton V.R., Gomez-Pinilla F. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience 2008, 155:1070-1078.
25. Yang Y.J., Qian H.Y., Huang J., Li J.J., Gao R.L., Dou K.F., Yang G.S., Willerson J.T., Geng Y.J. Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts. Arteriosclerosis, Thrombosis, and Vascular Biology 2009, 29:2076-2082.