The effects of adjuvant immunoglobulin m-enriched immunoglobulin therapy on mortality rate and renal function in sepsisinduced multiple organ dysfunction syndrome: Retrospective analysis of intensive care unit patients

Journal of International Medical Research

Volumn 40, Issue 3, 2012, Pages 1166-1174

  Yavuz, Lütfi ^a   Aynali, G ^b   Aynali, A ^c   Alaca, A ^d   Kutuk, S ^c   Ceylan, B G ^a  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c State Hospital of Isparta   (Turkey)

^d Afyon State Hospital   (Turkey)

Author keywords

APACHE II score; IgM enriched immunoglobulin; Mortality; Multiple organ dysfunction syndrome (MODS); Sepsis

Indexed keywords

ANTIBIOTIC AGENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGED; ANTIBIOTIC THERAPY; APACHE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; HUMAN; IMMUNOGLOBULIN M ENRICHED IMMUNOGLOBULIN THERAPY; IMMUNOTHERAPY; INTENSIVE CARE; KIDNEY FUNCTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORTALITY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; RETROSPECTIVE STUDY; SEPSIS; TREATMENT DURATION;

EID: 84863092287     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001204000337     Document Type: Article

References (29)

1. Schmid A, Burchardi H, Clouth J, et al: Burden of illness imposed by severe sepsis in Germany. Eur J Health Econ 2002; 3: 77-82.
2. Griffiths B, Anderson ID: Sepsis, SIRS and MODS. Surgery (Oxf) 2009; 27: 446-449.
3. Ceylan BG, Yavuz L, Eroǧlu F, et al: The effects of adjuvant therapies for sepsis on hepatic and renal function: a retrospective analysis of 108 ICU patients. Turk J Med Sci 2010; 40: 949-957.
4. Camporota L, Wyncoll D: Practical aspects of treatment with drotrecogin alfa (activated). Crit Care 2007; 11(suppl 5): S7.
5. Abraham E, Singer M: Mechanisms of sepsisinduced organ dysfunction. Crit Care Med 2007 35: 2408-2416.
6. Sakr Y, Dubois MJ, De Backer D, et al: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004; 32: 1825-1831.
7. Issa N, Messer J, Paganini EP: Renal assist device and treatment of sepsis-induced acute kidney injury in intensive care units. Contrib Nephrol 2007; 156: 419-427.
8. Buda S, Riefolo A, Biscione R, et al: Clinical experience with polyclonal IgM-enriched immunoglobulins in a group of patients affected by sepsis after cardiac surgery. J Cardiothorac Vasc Anesth 2005; 19: 440-445.
9. Reshetnikov EA, Baranov GA, Chuvanov MV, et al: Immunotherapy in complex treatment of surgical sepsis. Khirurgiia (Mosk) 2008; 7: 11-14 [in Russian, English abstract].
10. Azevedo LC, Park M, Schettino GP: Novel potential therapies for septic shock. Shock 2008; 30(suppl 1): 60-66.
11. Fabrizio K, Groner A, Boes M, et al: A human monoclonal immunoglobulin M reduces bacteremia and inflammation in a mouse model of systemic pneumococcal infection. Clin Vaccine Immunol 2007; 14: 382-390.
12. Yildiz BD, Yorganci K: Current trends and future implications in sepsis treatment. Turk J Med Sci 2008; 38: 501-510.
13. Norrby-Teglund A, Ihendyane N, Darenberg J: Intravenous immunoglobulin adjunctive therapy in sepsis, with special emphasis on severe invasive group A streptococcal infections. Scand J Infect Dis 2003; 35: 683-689.
14. Darenberg J, Ihendyane N, Sjölin J, et al: Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebocontrolled trial. Clin Infect Dis 2003; 37: 333-340.
15. Siqueira C, David C, David C: Kinetics of immunoglobulins in septic shock patients. Crit Care 2011; 15(suppl 1): P269.
16. Kress HG, Scheidewig C, Schmidt H, et al: Reduced incidence of postoperative infection after intravenous administration of an immunoglobulin A-and immunoglobulin Menriched preparation in anergic patients undergoing cardiac surgery. Crit Care Med 1999; 27: 1281-1287.
17. Kim HB, Ahn HS, Kwon JS, et al: Validation of POSSUM-physiological score as predictors of post-operative morbidity and mortality after emergency operation for peptic ulcer complications. J Korean Surg Soc 2009; 77: 391-398.
18. Choi WH, Hwang SY, Jun SY, et al: Usefulness of the Sequential Organ Failure Assessment (SOFA) score in patients with sepsis due to intra-abdominal infection. J Korean Surg Soc 2009; 76: 273-278.
19. Chen YC, Lin MC, Lin YC, et al: ICU discharge APACHE II scores help to predict post-ICU death. Chang Gung Med J 2007; 30: 142-150.
20. Khwannimit B: Serial evaluation of the MODS, SOFA and LOD scores to predict ICU mortality in mixed critically ill patients. J Med Assoc Thai 2008; 91: 1336-1342.
21. Peres Bota D, Melot C, Lopes Ferreira F, et al: The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction. Intensive Care Med 2002; 28: 1619-1624.
22. van der Poll T, van Zoelen MA, Wiersinga WJ: Regulation of pro-and anti-inflammatory host responses. Contrib Microbiol 2011; 17: 125-136.
23. Pettilä V, Pettilä M, Sarna S, et al: Comparison of multiple organ dysfunction scores in the prediction of hospital mortality in the critically ill. Crit Care Med 2002; 30: 1705-1711.
24. Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286: 1754-1758.
25. Mountain SA, Hameed SM, Ayas NT, et al: Effect of ambient workload in the intensive care unit on mortality and time to discharge alive. Healthcare Q 2009; 12: 8-14.
26. Alejandria MM, Lansang MAD, Dans LF, et al: Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev 2010; 2: CD001090.
27. Rieben R, Roos A, Muizert Y, et al: Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation. Blood 1999; 93: 942-951.
28. Langenberg C, Bellomo R, May C, et al: Renal blood flow in sepsis. Crit Care 2005; 9: R363-R374.
29. Bellomo R, Wan L, Langenberg C, et al: Septic acute kidney injury: new concepts. Nephron Exp Nephrol 2008; 109: e95-e100.