Tolerability and Pharmacokinetics of a New P-Glycoprotein Inhibitor, HM30181, in Healthy Korean Male Volunteers: Single- and Multiple-Dose Randomized, Placebo-Controlled Studies

Clinical Therapeutics

Volumn 34, Issue 2, 2012, Pages 482-494

  Kim, Tae Eun ^a   Gu, Namyi ^a   Yoon, Seo Hyun ^a   Cho, Joo Youn ^a   Park, Kyung Mi ^b   Shin, Sang Goo ^a   Jang, In Jin ^a   Yu, Kyung Sang ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Hanmi Pharmaceutical Co Ltd   (South Korea)

Author keywords

HM30181; P glycoprotein inhibitor; Pharmacokinetic properties; Tolerability

Indexed keywords

GLYCOPROTEIN P INHIBITOR; HM 30181; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ADULT; ANOREXIA; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; COUGHING; DIARRHEA; DIZZINESS; DRUG ACCUMULATION; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EXCRETION; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; EPIGASTRIC DISCOMFORT; EPISTAXIS; EYE DISEASE; EYELID ERYTHEMA; EYELID PRURITUS; FATIGUE; GASTROINTESTINAL SYMPTOM; HUMAN; INJECTION SITE PAIN; KIDNEY CLEARANCE; KIDNEY DISEASE; LACERATION; LOOSE FECES; MALE; MAXIMUM PLASMA CONCENTRATION; NEUROLOGIC DISEASE; NOCTURIA; NORMAL HUMAN; NOSE CONGESTION; PHARYNGITIS; RESPIRATORY TRACT DISEASE; RHINORRHEA; SINGLE DRUG DOSE; SKIN BRUISING; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; UROGENITAL TRACT DISEASE;

ADULT; BENZOPYRANS; DOUBLE-BLIND METHOD; HUMANS; ISOQUINOLINES; MALE; P-GLYCOPROTEIN; TETRAZOLES; YOUNG ADULT;

EID: 84863077446     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2012.01.003     Document Type: Article

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